Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 4.1e-29 4.9e-25 88.0 0.1 2 64 10 73 9 74 0.98

2 3 1.6 1.9e+04 -3.6 0.0 10 34 87 111 85 115 0.62

3 3 0.73 8.8e+03 -2.5 0.0 32 44 192 208 173 210 0.61

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	4.1e-29	4.9e-25	88.0	0.1	2	64	10	73	9	74	0.98
2	3	1.6	1.9e+04	-3.6	0.0	10	34	87	111	85	115	0.62
3	3	0.73	8.8e+03	-2.5	0.0	32	44	192	208	173	210	0.61

Coding Sequence: ATGGGCGACAGCCAGTTGAGCCGTTTTGAAAAATCCCTAGGTCTGTTAACTACGAAATTCGTTTCGTTGTTGCAGAAGTCAACGGGCGGCGTGCTCGACTTAAAAGTAGCCGCCGATTTGCTAGCTGTGAGGCAAAAACGGAGAATCTACGATATTACCAATGTGCTAGAGGGGATAGGTTTAATTGAGAAGAAAAGCAAGAACAGCATACAGTGGAAACCGTATACATACAAAGATTCCGTCCCAGGGTGCAACACACAGGAATTTTCTATAAAGGtggccaatttaaaaaaagaattatcgAGCTTAGACGATTACGAGCACGAATTAGATAAACACAAGCAGTGGATAGAGCAGAGCATAAGAAATACCACGGAAGatatagatttaaaaaagtatttgtaTTTAAGTGTGAAAGATTTCGGAACGTGTTATAAGGAAGATGACACAGTTTTGATCGTTAATGCTCCACTTAATTACACGACagtaaaatttcagAAGCCCGATGAAGATAAGTataatttaagaataaagtcttCAGGAAATCCGATAGCAGTTAATTTGTTATTATCTGAAATTAATACTGTACCGACGAAATCTGCTAAAAGGACATATGATAGTACAAGTATTAAGAGAGAGCCACAAGAACCAGAGGCAAAGAAAAGGTTAATTAGTGATGATCCTGATGTGGCTGTAGCAGAAATTCTCTTTAAAAAGATCACGGATTATCAACAAAGAATGCATCACTGTGAAACACGAGAAGGTGTCGATCCCTTTCTACGCCTTAGTCCCGTTTCTCTTAATCAAGATTATTCCTTCGCGCTTTCTGAATCCGAAGGCGTGCAAGATTTATTCGATAAAACATCACTGGCAACGTAG
Protein Sequence: MGDSQLSRFEKSLGLLTTKFVSLLQKSTGGVLDLKVAADLLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKPYTYKDSVPGCNTQEFSIKVANLKKELSSLDDYEHELDKHKQWIEQSIRNTTEDIDLKKYLYLSVKDFGTCYKEDDTVLIVNAPLNYTTVKFQKPDEDKYNLRIKSSGNPIAVNLLLSEINTVPTKSAKRTYDSTSIKREPQEPEAKKRLISDDPDVAVAEILFKKITDYQQRMHHCETREGVDPFLRLSPVSLNQDYSFALSESEGVQDLFDKTSLAT

Sequence clustering based on sequence similarity using MMseqs2