Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.82 5.5e+03 -1.3 0.1 34 44 126 136 117 139 0.66

2 6 0.0053 35 5.7 0.4 20 46 140 166 130 169 0.85

3 6 0.0021 14 7.0 0.4 22 47 170 195 167 200 0.86

4 6 0.00037 2.5 9.4 0.1 21 47 197 223 194 230 0.89

5 6 0.13 8.9e+02 1.2 0.1 22 52 226 256 222 256 0.88

6 6 6.6e-07 0.0043 18.2 0.1 23 53 255 285 251 286 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.82	5.5e+03	-1.3	0.1	34	44	126	136	117	139	0.66
2	6	0.0053	35	5.7	0.4	20	46	140	166	130	169	0.85
3	6	0.0021	14	7.0	0.4	22	47	170	195	167	200	0.86
4	6	0.00037	2.5	9.4	0.1	21	47	197	223	194	230	0.89
5	6	0.13	8.9e+02	1.2	0.1	22	52	226	256	222	256	0.88
6	6	6.6e-07	0.0043	18.2	0.1	23	53	255	285	251	286	0.91

Coding Sequence: ATGTCTGGGGAAATTTCAATAGCAATTGCAGAAactGCGGAAGATTCAAACGAGAATTACACATTTCTTCCATTTGTTAAAGTCGACGAAGGTATGATGATTTTAAACGGACACCCAATCTTCCAAGACATAACTCAATTGAATGATGTGGACGATTCAATTTTGTACATACCAGTCACCGACGATATGAGTACAAACAGTGACATCGCCGACATAACGTTCCAAGAAACTTCAGATTtagagaattttttaaatgaacatAATTATCATCATAATGTTCCTGATATTTCCAATGACAGTACGCTTGATTTGGGGTATACATTCTATATGCAAAATAAGAACAGCTATCATAAATGTTCGTTCTGTGATAAATCGTTTACCACATTGGGTGCTTTAAGGAGGCACCTCAGATCTCACACTGGAGAAAGGCCTTATCAATGCGAGGTGTGTGAGAAGAAATTTTCGCAGCAAAGTAATTTATGGAAGCATATCCGAATTCATACAGGTGAACGTCCATTTGAATGTCCGCATTGCCGACGCAAATTTTCCCAAAGAGCTAATATGCAAAAGCATTTAGTTGTTCATTCAGGGGAAAAGCCATTTCAGTGTCCTAGCTGTGATCGTTCCTTTACCCAACAAGCAAACCTTTCCAAACATATGCGCTTACACACAGGTGATCGACCGTTTCAATGTAAGTACTGTTCAAAAAAGTTTTCCCAGCGTTCCAATATGTTAAAGCATCAGAATTTACATGAAGGCGTCAAACCTTACACTTGCCatatttgttttgttgcaTTCACTCAACAAAGTAATCTTAAAAAGCATGTTCAGTTGCACAATAATGAGAAACCTTTCGTTTGTGGTGCATGCAACAAAGGGTATGTCCAGAAAGTAAGTTTGATAAAGCATATGGAACAGTGCAGCAGTTTGATGGAGACTGTGGAAACAATATTCGATGTGAGTTCGCCAAAGTTGATCCAAGTTCTTAGTGAGAATGATGAACCGAGGAATTTTTACATTACCGAAAATCGTGAGCTTATAAAAATGGAACCAAGCGTTTCACTGGAAGAAGAATCatga
Protein Sequence: MSGEISIAIAETAEDSNENYTFLPFVKVDEGMMILNGHPIFQDITQLNDVDDSILYIPVTDDMSTNSDIADITFQETSDLENFLNEHNYHHNVPDISNDSTLDLGYTFYMQNKNSYHKCSFCDKSFTTLGALRRHLRSHTGERPYQCEVCEKKFSQQSNLWKHIRIHTGERPFECPHCRRKFSQRANMQKHLVVHSGEKPFQCPSCDRSFTQQANLSKHMRLHTGDRPFQCKYCSKKFSQRSNMLKHQNLHEGVKPYTCHICFVAFTQQSNLKKHVQLHNNEKPFVCGACNKGYVQKVSLIKHMEQCSSLMETVETIFDVSSPKLIQVLSENDEPRNFYITENRELIKMEPSVSLEEES

Sequence clustering based on sequence similarity using MMseqs2