Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.26 1.7e+03 0.3 0.0 22 44 3 25 1 29 0.86

2 8 0.0026 17 6.7 0.0 20 47 29 56 26 62 0.85

3 8 0.013 88 4.5 0.0 26 52 89 115 83 117 0.89

4 8 0.0032 21 6.4 0.0 19 48 138 167 129 172 0.85

5 8 0.051 3.4e+02 2.6 0.0 22 51 169 198 165 201 0.85

6 8 0.33 2.2e+03 -0.0 0.0 21 47 196 222 194 228 0.71

7 8 0.78 5.2e+03 -1.2 0.0 22 44 225 247 221 252 0.74

8 8 7.2e-05 0.47 11.7 0.0 20 44 251 275 244 280 0.90

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.26	1.7e+03	0.3	22	44	3	25	1	29	0.86
2	8	0.0026	17	6.7	20	47	29	56	26	62	0.85
3	8	0.013	88	4.5	26	52	89	115	83	117	0.89
4	8	0.0032	21	6.4	19	48	138	167	129	172	0.85
5	8	0.051	3.4e+02	2.6	22	51	169	198	165	201	0.85
6	8	0.33	2.2e+03	-0.0	21	47	196	222	194	228	0.71
7	8	0.78	5.2e+03	-1.2	22	44	225	247	221	252	0.74
8	8	7.2e-05	0.47	11.7	20	44	251	275	244	280	0.90

Coding Sequence: ATGGGCGAgaaaccctttaaatgcaCTGCATGTGATAAAGTTTTTGTTCATAACAGCAGCCTGAAAGCACACATGGTCATTCATCAAGAAGAAAAATCCTTCAAATGTGACCAGTGTGATGAAGCTTTTCTAGAAAGTCGCGCCCTGAAAAGACACCTAATAATTCATTTGGATGAGAAACCGTTTAAATGCCACTTGTGCAGTAAAGGTTTTAACTACAAACACAGCCTGAAATCGCACATATTGGTTCACGAGATATCGTTTAAATGCCGCATATGTAATGAAACTTTTGCTGAAAGCGGCAGTCTGAAATCGCACTTGTCGCTTCACAAGGATGAGAAACCGTTCAAATGCAATTTGTgtgataaattttatttacgaaATACCAGCCTGAAAGCGCACATGTCAGTTCATAAAGGCGAAAAACCGTTTAAATGTAACCAGTGTGATAAATCTTTTCGAGAGAATGTCGTCCTGAAAAGACACCTGGTGATCCACATGGACGAGAAACCGTTTAAATGTCACCTGTGTGGGCAAGGTTTTAATCAAAATCACAGCCTCAAAGCGCACATATTAATTCATAAGGGCGAGAAGCCGTTTAAATGCCACTTGTGTGATAAAAGCTTTATCCGTAACGTTAGTCTCAAAGCGCACGTACTACTTCATATGGACGAgaaaccctttaaatgcaaTTTGTGTGATAAAGAGTTTACCCGAAGAAGTGGTCTCAAGGCGCACTTATTGAGTCATGAAGCcgaaaaaccttttaaatgtgacCGGTGTAATAAAGCCTTTCGACAAAACGGCAATCTGAAAAGACACGTATTAGTTCACCAAAATGATATTAGTCATGCCAATGTAAAATTCGATAATGAGGCGCAATGTTCCTTTATACAGGATGGTTCATCGACTAGCTTTTTTGCAAAGAGCATCTTTCCAATCTCCCTAAATAATTGA
Protein Sequence: MGEKPFKCTACDKVFVHNSSLKAHMVIHQEEKSFKCDQCDEAFLESRALKRHLIIHLDEKPFKCHLCSKGFNYKHSLKSHILVHEISFKCRICNETFAESGSLKSHLSLHKDEKPFKCNLCDKFYLRNTSLKAHMSVHKGEKPFKCNQCDKSFRENVVLKRHLVIHMDEKPFKCHLCGQGFNQNHSLKAHILIHKGEKPFKCHLCDKSFIRNVSLKAHVLLHMDEKPFKCNLCDKEFTRRSGLKAHLLSHEAEKPFKCDRCNKAFRQNGNLKRHVLVHQNDISHANVKFDNEAQCSFIQDGSSTSFFAKSIFPISLNN

Sequence clustering based on sequence similarity using MMseqs2