Dmel029082.1
Basic Information
- Insect
- Danaus melanippus
- Gene Symbol
- Foxa2
- Assembly
- GCA_010014825.1
- Location
- JAAAKD010000756.1:37838990-37843749[+]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.6e-17 7.8e-14 53.2 0.1 29 82 10 60 5 64 0.91
Sequence Information
- Coding Sequence
- atgaaaCCACAGACGCATTCACTTGGCTGTACTTATGTCTgGGATCGATTTCCGTTCTATAAAGCGAACGACGAGCGTTGGAAGAACTCCGTGAGGCACAATTTATCTATCAATCCACATTTCCGTAAGGGTGCCAGGGCGTCCCAGGGCGCTGGTCACCTTTGGTCTCTTGCAGCCAATGCAATAGATCTACTACCGTTACGAAACCAGACATATGAAAAGACTGACGTCCAAGAAACCCGAATAATTGAATGTCCCAAGGTAATAGTTCTGGATGAGGCCGCAATAGCCGCAGCGAGTATAATGCCCGATCAGGACTTATTCACCGGTGGTACAAtgttCCTAAATCCTGTTTCTACGGAACAAGTGGTACGTGAATGTGGTCTCATTACAGGCCTTTGA
- Protein Sequence
- MKPQTHSLGCTYVWDRFPFYKANDERWKNSVRHNLSINPHFRKGARASQGAGHLWSLAANAIDLLPLRNQTYEKTDVQETRIIECPKVIVLDEAAIAAASIMPDQDLFTGGTMFLNPVSTEQVVRECGLITGL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00795523; iTF_00287881; iTF_00744427; iTF_01506988; iTF_00778612; iTF_00355947; iTF_01401102; iTF_00255638; iTF_00256673; iTF_01152863; iTF_00025097;
- 90% Identity
- iTF_00642163;
- 80% Identity
- -