Basic Information

Gene Symbol
-
Assembly
GCA_030157275.1
Location
CM058067.1:12380068-12381608[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.011 0.88 10.5 1.7 1 23 148 169 148 169 0.96
2 11 0.015 1.2 10.0 0.4 1 23 211 232 211 232 0.93
3 11 8.7e-06 0.00071 20.2 4.4 1 23 238 260 238 260 0.97
4 11 0.011 0.89 10.4 2.5 1 23 266 288 266 288 0.96
5 11 4e-05 0.0032 18.1 4.9 1 23 295 317 295 317 0.97
6 11 0.0039 0.32 11.9 8.4 1 19 330 348 330 351 0.92
7 11 1.3e-05 0.0011 19.6 3.5 1 23 361 384 361 384 0.97
8 11 2.8 2.3e+02 2.9 1.0 3 23 393 410 392 410 0.72
9 11 1.7e-06 0.00014 22.5 0.9 1 23 416 438 416 438 0.98
10 11 4.7e-06 0.00038 21.0 0.1 1 23 444 466 444 466 0.98
11 11 5.1e-06 0.00042 20.9 0.8 1 23 472 494 472 494 0.97

Sequence Information

Coding Sequence
atgaaCTTAATCAAAGCAACAGTGACCAACGAAAACCTCACAAAAATCTGCAGAATTTGCCTGGAAGAAAAACCGATCGTTTTTGACAGCAGATTAAACATCGAATTCGAAATCAACGTTCTAATTAATATAACTGAAATGCTCACCAAATTAACGTCTCGGACGGACACAGAGGAACAGTTCAAGCCGAAGCTGATCTGCAACGACTGTCTCGGAGATTTGAAAACTGCTTATCTTTTGCTATTGAAATATGATGAAGCTGACAGGATCCTCCAAGAGTTTCTCGCGAATTACGTGAAGAAAGAAGAGTTGGAAAGCGAGGACGAAAAAGTGGATGTGGAGCCTCATTACGAGACGCGAACTTCGCGACGAACGAAAAAGCGAACCCGGAAGAAAAAAGCGAAAGATGAAGAAGAAACAGATTTTTCCAAAAGTAGACTTCATTCTTGCCCCATTTGTACGAAAGACTTCACCGCGCTCGAATTACGTGATCATGCTCACACTCATAAAGCTCTGAAGAAGTATCTCAGCATTCCTAATGAACAGAAAGTGACCCCCACGACGAAGTTTTCGACGCGGAGACACATAACTGACCCCCAAGAGACGATTTTTAATAGGCCAGTTAAGCTGCATAAGTGCCCGTATTGTAACCAAGAATTCCCAGTTGAAGAATTCAGAGTCCATATTGATATCCATCGGCAACAAAGTGAATATAAATGTGACAAGTGCGACCGAGTGTTCAAAAGGCTCAACCATTTGAACACTCATCGCGTAAAACACCTGAAAGAGTTCCCCTATAAATGTGAACAGTGTGATAAAGGCTTTGTTATCAAGAAAAATTACGACTGTCACATTCTCACCCACACAAACGACGAGTTACCTCACGAGTGTCGATTTTGCTTTAAAAGATTCTCAAATCCTGAGCATCTCAACAGACACCAAATTATTCACACTGAGAATGTGACGTATTCGGTGAAGTACCGAGTTTGTAAGTGTCATCATTGTCTCAAAAGTTTCAAGGATAAAGATGAGCTTAAAACTCATAATTGTGTTCCAGTGGAACAAACAGTTAGTACTAGATTTCCCTGTAAAACTTGtaagaaagtttttaaacattcaagCGGGCTGTATAATCACACGAGGAATATCCATAAACTTAAAGGTGGGAAAATTCTGTGTTCAGTTTGCGGAAAATacgtttcaaatatttacaatcaTATGATGAGGCACACTGGAGAGAAGCCTTATCAGTGTAACCAGTGCGAAAAGAGGTTCATTTCGAAACCGCAGCTGAAACAACATTTGTTGGTGCATTCGGGACTAAAACCGTACGTTTGTAGCGTTTGTGCGAAGgcttttaacaatttgtataatttacaAGTTCATGAAAGGATACACGTTGGAGATAGATGCCATATTTGCCCGATTTGTGGGAAAGGATTCTTGGAAAAGTCgtatttgaagaaacacatGAACGTGCATGCCAAACAGTGA
Protein Sequence
MNLIKATVTNENLTKICRICLEEKPIVFDSRLNIEFEINVLINITEMLTKLTSRTDTEEQFKPKLICNDCLGDLKTAYLLLLKYDEADRILQEFLANYVKKEELESEDEKVDVEPHYETRTSRRTKKRTRKKKAKDEEETDFSKSRLHSCPICTKDFTALELRDHAHTHKALKKYLSIPNEQKVTPTTKFSTRRHITDPQETIFNRPVKLHKCPYCNQEFPVEEFRVHIDIHRQQSEYKCDKCDRVFKRLNHLNTHRVKHLKEFPYKCEQCDKGFVIKKNYDCHILTHTNDELPHECRFCFKRFSNPEHLNRHQIIHTENVTYSVKYRVCKCHHCLKSFKDKDELKTHNCVPVEQTVSTRFPCKTCKKVFKHSSGLYNHTRNIHKLKGGKILCSVCGKYVSNIYNHMMRHTGEKPYQCNQCEKRFISKPQLKQHLLVHSGLKPYVCSVCAKAFNNLYNLQVHERIHVGDRCHICPICGKGFLEKSYLKKHMNVHAKQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00753258;
90% Identity
iTF_00753258;
80% Identity
-