Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.004 44 5.6 0.0 21 43 6 28 2 33 0.90

2 9 1.2e-06 0.013 16.9 0.1 21 54 34 67 29 67 0.90

3 9 0.078 8.6e+02 1.4 0.2 22 43 89 110 84 115 0.84

4 9 0.0077 85 4.6 0.1 21 43 116 138 111 144 0.89

5 9 0.00069 7.7 8.0 0.2 14 48 146 183 140 187 0.73

6 9 0.007 77 4.8 0.1 21 43 184 206 180 212 0.90

7 9 0.002 22 6.5 0.8 21 43 212 234 207 240 0.89

8 9 0.0028 31 6.0 0.1 20 51 239 270 235 272 0.84

9 9 0.015 1.7e+02 3.7 0.1 21 43 268 290 258 295 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.004	44	5.6	0.0	21	43	6	28	2	33	0.90
2	9	1.2e-06	0.013	16.9	0.1	21	54	34	67	29	67	0.90
3	9	0.078	8.6e+02	1.4	0.2	22	43	89	110	84	115	0.84
4	9	0.0077	85	4.6	0.1	21	43	116	138	111	144	0.89
5	9	0.00069	7.7	8.0	0.2	14	48	146	183	140	187	0.73
6	9	0.007	77	4.8	0.1	21	43	184	206	180	212	0.90
7	9	0.002	22	6.5	0.8	21	43	212	234	207	240	0.89
8	9	0.0028	31	6.0	0.1	20	51	239	270	235	272	0.84
9	9	0.015	1.7e+02	3.7	0.1	21	43	268	290	258	295	0.86

Coding Sequence: ATGAGATGCCACACCGGTGAGAGGCCCTACCCCTGCAACGTTTGTAAGAAAGGATTCATCAAATCCGGTGATTTGAGAAGACATGAGCGCTCTCACACGGGGGAAAAACCGTATTCCTGCAAGATATGCCAAAAACTGTTCTCTGAATCGACCACTTTAAGAAGACACGAACGGATTATGCATGGCGAGAAACCTGAAGTCTCACAGGTGAAAAAATACAAACGATCAACCATTATCAAAGAAGATGTGACGGCCAATGTGGGCGACAAACCCTTCGCCTGTGAAGTATGCAAGAAATCGTTCATTCGGGCCTGTGATCTAAAAAGGCATGAACGCTGCCACACGGGTGAAAAACCATATTCTTGTACGATGTGTGATAAACAGTTTTCAGAATCGACCACTTTAAAAAGACACGAGCGGCAGCACACCGGAGAACTGCCGAGGCCACGCGACAGCCTAGAGGCGAGTATAAGAGCGCGGACGTGCCAAATATGCGGAAAATTATTCAAGAAATCGACTATATTAAAGAACCATATAAGAATCCATACAGGGGAGAAGCCTTACCAGTGCTCAATGTGCGACAGATTGTTCGCACAACATTCCAACTTGAAATCACACGAACGAACGCACACCAATGAAAAACCCTACATCTGTCAAGTATGCAAAAAGCAGTTCTCACAACATAGCACTCTGAGGAGACACGAGCGTACCCACAGGAACGAGAAACCATACTCCTGTGAGATATGCAACAAGACTTTCACACAGGGCAGTACTGTAAAGAGTCATATGAGAATACATACCGGCGAGAAGCCATATTCGTGCGGGGCGTGCGCCCGGGCGTTCACGACGTCGAGCACTTTGAGGAAACACGAACAAACTCATACAGGGGACACGAGCGGCGATAGTTAA
Protein Sequence: MRCHTGERPYPCNVCKKGFIKSGDLRRHERSHTGEKPYSCKICQKLFSESTTLRRHERIMHGEKPEVSQVKKYKRSTIIKEDVTANVGDKPFACEVCKKSFIRACDLKRHERCHTGEKPYSCTMCDKQFSESTTLKRHERQHTGELPRPRDSLEASIRARTCQICGKLFKKSTILKNHIRIHTGEKPYQCSMCDRLFAQHSNLKSHERTHTNEKPYICQVCKKQFSQHSTLRRHERTHRNEKPYSCEICNKTFTQGSTVKSHMRIHTGEKPYSCGACARAFTTSSTLRKHEQTHTGDTSGDS

Sequence clustering based on sequence similarity using MMseqs2