Basic Information

Gene Symbol
Bcl11a
Assembly
GCA_033807575.1
Location
CM066368.1:5188394-5197471[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.16 14 7.7 5.1 1 14 173 186 173 198 0.71
2 14 2.2e-06 0.00018 23.0 3.3 1 23 204 226 204 226 0.96
3 14 1.1e-05 0.00095 20.7 0.8 1 23 232 254 232 254 0.98
4 14 2.7e-06 0.00022 22.7 4.0 1 23 260 282 260 282 0.98
5 14 0.00036 0.03 16.0 0.3 1 23 315 337 315 337 0.98
6 14 0.00021 0.018 16.7 1.4 1 23 343 365 343 365 0.93
7 14 3.8e-07 3.2e-05 25.4 0.6 1 23 371 393 371 393 0.98
8 14 0.00026 0.021 16.5 1.1 1 23 399 421 399 421 0.98
9 14 0.00037 0.031 16.0 2.1 1 23 427 450 427 450 0.94
10 14 8.2e-06 0.00068 21.2 2.2 1 23 458 480 458 480 0.97
11 14 0.00034 0.028 16.1 0.8 1 23 501 523 501 523 0.97
12 14 5.7e-06 0.00047 21.7 3.0 1 23 529 551 529 551 0.98
13 14 4.8e-06 0.0004 21.9 2.1 1 23 557 580 557 580 0.96
14 14 0.00016 0.013 17.1 1.2 1 23 586 608 586 608 0.96

Sequence Information

Coding Sequence
ATGGAGGAGTTACACTCCTGCAGTTGTTGCTTGGTGCGTCCTCCGGAAAAAGGCCTCAGGAAGTTGTATAAACATCTCGGCAAAACAGAGATATATTATGAAATGCTGAAAAACTGTTTCGATATTAATCTCGGGATAGGAAATGACGAGTGTGGGATCTGCGACGTGTGTGTAGGGCGGCTGCGGGACGCGAGCGACTTCAAGCTGCAAGTGCAGCGTAGCCAGGCCCAGCTGCATGCTCGCCTCAAGGGTGTGGTTACTGCTAATGACAAGTTGAAAATAAAGTTCGAGAAAGCTTCCGCAGATGAAACAATCATAAACGACATTAAGCTGGAGAAGTCCGAGGTGGAGATGGCTGATGGCGAGGTCGTATCAGTGGCTATTTACGGTGGACCGCCAGCGCCTTCAGCGCAACCCGTTCCTGCCGCGTCTAACCGCATCTTTTTTGCGTCAGTTCCGACCCTCACCAACCTCGACGCTACCGAGCCGCCTCCGGCTTCAAACCGCACTAAAGTCCACGAGTGCGACATATGCCACAAAACATTCAAGAACCCAAATGCGAAAAACAAACTCATAATCCACCGCCGCTCCCACACTGGAGAGAAACcatattcgtgcaatatatgcGACAAAAGATTCGTACAAAAGAGCCACTTAAATACTCATTACGCATACCACATTGGGAAGTTCAAATTCTCTTGCGAACAATGCGACACGAAATTCACGCAAAAAAACCAATGGGTTGTGCATATGCGGATACACACTGGTGAAAGACCGTACTCGTgtgaaatttgcaataaaacattCAAGCAAAAAGGACACTTGAccgttcataaaaaaaatcattctaaATACGATCCTAGTCGTGTAGAGCCAGGAGAAATAACAGTGTGTAAAACAGAGTGGGCAGAAGAATCGAACAAACAAGTACCCACCGAACACTTCCCATGTGATATATGCAAAAAACAATTTGCAGAAGAAAACTATTTAAACATTCATTTAAAGAATCATCCTGGTGATTATCCATTCACCTGTGAAACTTGCGATAGAAAATTCAAGACGCAGTCTGCATTAGATATTCATAAGTACGATCACACGGGGGGGAAACCTTTTAAATGTGAAGAATGCGGTAAACGATATACGTCAAAAAGCGCTTTAAGGCTTCATGCAAGAATTCACTCCGATGACTATAGATTCTCGTGCGATGTGTGTAATAAACGATTCCTACATAAAGACGCTATGATCATACACATGCGTGTACACACTGGTGAAAAGCCTTATACCTGTGAGATATGCCAAAAAAAGTTCCCATACAGATGTGgcttaaaaaatcatttattagcACAACATAAACAAATAATGGACAAACAGTTCTGCTGCGATATTTGTGGGAAACGATTTGCACTACAGGGAACATTAAGTAAACATATGAACAAACACGCTGAGAAGGAAAAGGCAGAAAAAGCTATTAAGGAAGGGAGGAAGGAAGATCTCAAAACGTTTATGTGTGAAATATGTAGCAAACGGTTTACAACGAAAGGTATCTTAagaaaccatagagaaatacatAATGAAGAAAAACCCTTTGAATGCGAAGTATGCCACAAGACATTTCGGATGAAGAAGTATTTAGAAGACCATATGAAGGTACACGATAACTTTAAACAACACGCTTGCGAAGTATGTGGCCAACAGTTTAGACATAAATCTGCCTTGACAGTTCATATCCGACGAATGCATTCAGACATCAGACCACATTGTTGTGATGTTTGTAAAAAAGCTTTTCCAGTACTTGCTGAATTAAAAGCGCATTATCGTGTTCACACCGGTAAAATAGTTACCTGTGCATCGCAGTTCGCACGTAGCATATGGACGAGTCTAGACAAAAATGGTTTGTCTAATAACCTTAGAGCAAAATATGCGCACTCCCCTCACTCAGCGTCTAGTGAGGCTGGCATCGCCACAAGTGTGTTCGTTCCACAAATCACTGACACCGCCATCAATAAACATGGATACAAAATATTCTAA
Protein Sequence
MEELHSCSCCLVRPPEKGLRKLYKHLGKTEIYYEMLKNCFDINLGIGNDECGICDVCVGRLRDASDFKLQVQRSQAQLHARLKGVVTANDKLKIKFEKASADETIINDIKLEKSEVEMADGEVVSVAIYGGPPAPSAQPVPAASNRIFFASVPTLTNLDATEPPPASNRTKVHECDICHKTFKNPNAKNKLIIHRRSHTGEKPYSCNICDKRFVQKSHLNTHYAYHIGKFKFSCEQCDTKFTQKNQWVVHMRIHTGERPYSCEICNKTFKQKGHLTVHKKNHSKYDPSRVEPGEITVCKTEWAEESNKQVPTEHFPCDICKKQFAEENYLNIHLKNHPGDYPFTCETCDRKFKTQSALDIHKYDHTGGKPFKCEECGKRYTSKSALRLHARIHSDDYRFSCDVCNKRFLHKDAMIIHMRVHTGEKPYTCEICQKKFPYRCGLKNHLLAQHKQIMDKQFCCDICGKRFALQGTLSKHMNKHAEKEKAEKAIKEGRKEDLKTFMCEICSKRFTTKGILRNHREIHNEEKPFECEVCHKTFRMKKYLEDHMKVHDNFKQHACEVCGQQFRHKSALTVHIRRMHSDIRPHCCDVCKKAFPVLAELKAHYRVHTGKIVTCASQFARSIWTSLDKNGLSNNLRAKYAHSPHSASSEAGIATSVFVPQITDTAINKHGYKIF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00410559;
90% Identity
-
80% Identity
-