Basic Information

Gene Symbol
Lztr1
Assembly
GCA_033807575.1
Location
CM066363.1:5388231-5395026[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 5.5e-09 2.5e-06 28.9 0.0 50 109 58 128 50 129 0.91
2 9 2.4 1.1e+03 1.1 0.0 78 108 129 159 126 161 0.87
3 9 1.9e-08 8.8e-06 27.1 0.0 10 50 224 261 221 275 0.81
4 9 9.9e-06 0.0045 18.4 0.2 23 50 277 302 261 315 0.75
5 9 9.8e-06 0.0045 18.4 0.2 23 50 318 343 303 357 0.75
6 9 1.1e-05 0.0049 18.3 0.1 24 50 360 384 347 400 0.77
7 9 1.1e-05 0.005 18.3 0.1 24 50 401 425 387 439 0.77
8 9 2.1e-13 9.7e-11 43.1 0.1 23 96 441 515 427 530 0.80
9 9 2.5 1.2e+03 1.0 0.0 77 106 530 559 519 562 0.79

Sequence Information

Coding Sequence
ATGTTGAGAGCTGTTTTTCGGATCTCTCTTTTTCTCTGTTTCTCTAATCGGACCACCATCTgcagtggcgccaactggtggGTTGCTCACAGGGAAGCGCGCGAAGAACTAGCCCGACGTATAGACGAGGGCCTCGAAAAGCCCCTAGAAGTATATGACTACAAGGCGAAGCCCCGTCTCACTCTAAAATTACCAGAAGCCACTCCAGAAGCGTTCGACATGGTGCTTAACTTCATATACACGGACCGGATCGATCCGAGCGAGAAGTATGAGGACCCCGAAAAGCCCTCCACCATCCTCCAAGTAATGGAAGTCCTCCGCCTAGCGCTACGCCTGAACATTCCTCGCCTTCGCGGGCTCTGCGCTCGCTTCCTAAAGGCCAACCTTTGCTACAGCAACGTGTTACCAGCTCTCCACTCCGCACACCACGCTCAGTTGCATTCTGTTAAGGAGTACTGTCTCAGATTTTTAGTAAAGGATTACAACTTTACGCAAATAGTGATGTCGCCAGAATTCGAAACAATGGAAAAGAGTCTGATGGTGGAAATGATCCGTCGTCGGCACCGACCACAGGCCAAACCACCAGCGCCGCAGGAAAGCGACGAAGATATTATAGGAACAACGCTCGAGCAAGACATGTGCGTGTTcgtgggcggcgcgggcgcggggctGAGCGACGTGCGGCTGCGCGTGGGCGCCGCGTGGCGGCCCGCGCACCGCTCCATCctggccgcgcgcgccgcctacTTCGAGGCCATGTTCCGCTCCTTCTGCCCCAGCGACAACACCGTCAACGTGAGTGTACACACAGACACGGCGTGTTCGTGGCGGCCCGCGCACCGCTCCATCctggccgcgcgcgccgcctacTTCGAGGCCATGTTCCGCTCCTTCTGCCCCAGCGACAACACCGTCAACGTGAGTGTACACACAGACACGGCGTGTTCGTGGCGGCCCGCGCACCGCTCCATCctggccgcgcgcgccgcctacTTCGAGGCCATGTTCCGCTCCTTCTGCCCCAGCGACAACACCGTCAACGTGAGTGTACACACAGACACGGCGTGTTCGTGGCGGCCCGCGCACCGCTCCATCctggccgcgcgcgccgcctacTTCGAGGCCATGTTCCGCTCCTTCTGCCCCAGCGACAACACCGTCAACGTGAGTGTACACACAGACACGGCGTGTTCGTGGCGGCCCGCGCACCGCTCCATCctggccgcgcgcgccgcctacTTCGAGGCCATGTTCCGCTCCTTCTGCCCCAGCGACAACACCGTCAACGTGAGTGTACACACAGACACGGCGTGTTCGTGGCGGCCCGCGCACCGCTCCATCctggccgcgcgcgccgcctacTTCGAGGCCATGTTCCGCTCCTTCTGCCCCAGCGACAACACCGTCAACATTCAAATATGCGACACGGTGCCCTCAGAGGAAGCGTTCGACTCGCTGCTGCGCTACATTTACTACGGAGACACCAACATGCCTACTGAAGACTCGCTCTACTTGTTCCAAGCACCGATTTATTACGGGTTTACTAACAACCGTCTCCAAGTATTCTGCAAGCACAATCTACAGAGCAACGTCACCCCGGACAACGTATTAGCGATATTACAAGCGGCGGACCGAATGCGCGCCGCCGACATCAAGGAATACGCGCTCAAGATGATCGTGCACAACTTCTACCAGcTGGCCCACCAGGAGTCCATCAAGAGCCTCCCGCAGCCGCTGCTGGTGGACATCGTGGTGGCGCTGGCGTCGGCGCGGCGCGCGGactcgccgctgccgccgcgcgcgctgccCGCCTCCGCCTCCGCCGACACGCTGCCCGACGACGAGCACCGGCGCAGGGACCACCCCGGCTACTGGTAG
Protein Sequence
MLRAVFRISLFLCFSNRTTICSGANWWVAHREAREELARRIDEGLEKPLEVYDYKAKPRLTLKLPEATPEAFDMVLNFIYTDRIDPSEKYEDPEKPSTILQVMEVLRLALRLNIPRLRGLCARFLKANLCYSNVLPALHSAHHAQLHSVKEYCLRFLVKDYNFTQIVMSPEFETMEKSLMVEMIRRRHRPQAKPPAPQESDEDIIGTTLEQDMCVFVGGAGAGLSDVRLRVGAAWRPAHRSILAARAAYFEAMFRSFCPSDNTVNVSVHTDTACSWRPAHRSILAARAAYFEAMFRSFCPSDNTVNVSVHTDTACSWRPAHRSILAARAAYFEAMFRSFCPSDNTVNVSVHTDTACSWRPAHRSILAARAAYFEAMFRSFCPSDNTVNVSVHTDTACSWRPAHRSILAARAAYFEAMFRSFCPSDNTVNVSVHTDTACSWRPAHRSILAARAAYFEAMFRSFCPSDNTVNIQICDTVPSEEAFDSLLRYIYYGDTNMPTEDSLYLFQAPIYYGFTNNRLQVFCKHNLQSNVTPDNVLAILQAADRMRAADIKEYALKMIVHNFYQLAHQESIKSLPQPLLVDIVVALASARRADSPLPPRALPASASADTLPDDEHRRRDHPGYW

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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