Camp019150.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cydia amplana
Gene Symbol
MBD-R2
Assembly
GCA_948474715.1
Location
OX419654.1:23966128-23985629[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.9e-16 7.4e-13 48.4 0.0 6 66 903 960 898 1015 0.90

Sequence Information

Coding Sequence
ATGTGTTTCAGATGTAAAGTCATATCAAATATTTTTATGAAGATGTCAGACAAAGAAGTAATAGAAATAGATAGAGTAACCCCTACTGTCAATACAAGTAAGGAATCAGAAGCCGAAAATGTTGATGCAATAAAAAAATATATTGAAGAGCAAGACATTGTTTTAAGGTGTTCATCTGACAAGGATGCGGTGAACCAAATAATAAAAGATACATATAAAGGAGATAATAAAAACAACTTAGATTTAGAACTACAACTTACATTGTCCAATAATTCTGGCGTTGCCACAAGGGACTGTGAGATAAAACAACAGACCTACAATATAGGTTCCGAGTCAGTGTACAGTGAAGAAACAACAATGTCAGCATCTCCAAACCCATCATCAAATGATTCCTTGTTAGAACTAGAGAATGAAGAAACACTCGCTAATCAAGCAGCTGCAAATTTACTATCTTTGGGTCAAAACTGTATAAAAATGCATATAAATATAAAACAAAAAAAGTGTTCAGATGAAATCATAACCAATGCTCATGAATGCACATTCAAATCCAATGTAAATATTGATGGTAATGAAGAGTTGCCTGATAATGTAGAACTGCATCAACAAGGAGGTGGACAGAATAATGAAAAGAATATTGAATTAAATAGTACAAATATAAGTCCAAAGAATTCTGATAATGATTTACACCTGAGCAAAGAAGAAACAAAAATACAAAAGTTAGAAAATAAAGATGGTAATCAAAAGTTGCTAAACATCTCTGAGTTACAAAATAAAAATAGGTATAGTAAAGATGAGAAGTGTCAACCATCCACCTTACTGCATAAACTACTAACTTGCACCAGTAAATCAAGTAGTGAAATAAACAATTCAATTTTATTGGATAAAGACACCAAAACAGTACAAGAAAATAAAGAACATGGTGAAGAATCTTTGTCCATAGCAACAAGTGTAATGGATATGATACTTAATAATGCTGAAGTGGCCATCAGTAAGAAAAATGCTGGTGCTTTATCCAAACAATGTTTAAGCCCTGATAAAGCCAACTCCAGCGTTTCCCTGGCGATTGGATCAAAAGTAGAAGCCAAAGATTTCTGTGAGCTGTGGCATCCTGCTCAGATAGTAGAAGTGGACTGCGAGGAAATGGAGGTCTTGGTACAATATGACCAACAACCAAAAATGCACAATGAATGGATAAGCATAAGCAGCCCAAGGTTAAGACCTATAAGCAGTATAGTAACAAAGCCGCCATCGCGTCCGCATACACCCATGTCAGAAGCGCTCACCGAACCTAAAGTGGAAGACAAAATGAAAGTGACCTTTGCTGTAGGAGAACGATGTTTGGCTCGGTGGAGGGACAACCGCCGATTCATTGCAACAGTTCAAAAAGATTTGGGAAATGGTCATTATGAAGTTATGTTCGATGATGGGTTTCAATGGAAGTGCACTTTATCGAGAATGTACAAGCTAAAGGAAGCCAACGGGCATCAGGATTACCCTCGGTTTGGAGCGGGGGCCGCGCCGCCGCCCGTCGCCGCGCCCCTGGCCGCGACACTAGACGCGCCGCCCGCGGCGCCCGCGCCCGCCGCGCCTCCTCCCTTGTACCACACGCATCTGTTTGACCCGACCCGTGATTACTTAGGTTCCAAAAGCGAAAGGCGTGAGATGAAGCGAAAGCTAAACATCAAAGAAATATTCAATATTGGACAGAAACGAAAAAAACTACCAACAGTAGACAAAGAGTCCAAAAGTACCTTTGCTTCAGTAAAAGAAGAAATTAAAAATGAAATAAAATCTGAACCCGGTACTTTATCACATGAATCTGCTCAAACAGCAGAACCTCCCTTAAAGGAAACCATTTCTGAGACACAAGTAAAAAAAATTATAGCAAAGAAGCTACCTGTTAAGAAAAAAACTCTTGGAAAGAAAAAAATTAAATTGAAAAACATTGATGGCAAATCGGTTGTTTCTTCATCAAATGATACCAAGAAAGAAAAAATACCAGAAGCCGTTGCATCTATTATTGGTACAGTGTTTGCTAACGAACCTGAAGTGGAAGTTAAAGCGGAGCCACCTGATGAAGAAGTCATGGATGCTAATGCTAATGACATCAAGCCTGACGACCTGACAAACGCATTGGACATATGTAGTGCAGAGATCAAACAAGACATCGATGTCGTAACGGAAGAGGAAACAAAACCATTTGAAATTCAGGATGGAGTCAAGCACGAGGAAGTCATCGGTAAAATTAAGGAAGTGATCACAAAGTTAGAGGATGGCATAAACGAAGTGGAAAAGAAAGAGATAAAACCTGAAGTAGTTAAAGAAGAAACAGTACCGGAAGACGTGCAGCCGGTCGTGAACCCGGTAGAAACCAATGACAAAGAAAAGCAAAAGAAATCAAAAAGCTCGTCGAAAGTGAAAAAAGGAAAGAAGCTGAGGTTGATGCAAGAGAAGAAGGTTAAAAAACAAGTGGAAAAGGTGAAGTGTCAGTTGGAGGAGATGAAGAAGCAGGTGGAGGCGATGCGGCAGGAGATCATGCTGAAGACGGAGCAGCTGGCGAGCTCGCGGCGCGGCGAGTGCGCGGCGCCCGAGGCCGCGCTGCTGCCCGGCGAGTGGTGCGCGCGCTGGCTGGACGGCCAGCCCCAGGGCGCCGTCAGCGAGGCGCCCGCCAGCGGCGACTCGCCGCTCCCGCGACGCAGCGTCATGGTAGAGGACAAGCGGCTGCCGCCGGGCTGGACGAAACACATGGTGCGCAGGAGTCTGGGCAGCTCGGCCGGCAAGTGGGATGTAGTTTTAGTAAGCCCGGAAAATCGTAGACTTCACACTAAGAACGATATGCGGATGTACCTAGAGAACAACCCGCAGCCGGAGCTGAAACCGTTCGAGGCCGCTCTGATGGACTTCGGCATCCACCTGAAGCTGTCGCGGCGGCTCGGCTGGGTGCGCTCCTCGGCCGAGGGCGCGCCGCCGCCGCCGCCGCCCTGCCGCGACCTGCCCGCCTCCTCGCCGCTGCTCAAGCGATCCAAACTGAGCCTCAACAAGAACCACCACAAGTTGATGCACCACAAAAAGCGACCCAGGCTGAAAATCAAACCTCTGCGACCGCCTCCGATTTCGGAAGGTCCTGGTTTGCATCAGAGTTCTAAGGAGACCAATATGTGTTCTGAGCCAAGTGTAGCAGAGGAAGCTGTTCTTGACGGCGCCAGTATTAAAGATGGATTTGTTGATGTCGGTTCGTTAAGAGTTCAAGTTATTTCGACTCTGCTGCGATGTCCCGCCGAAGGGTGTTTTAAGAATTTCCGAAATACTACGTTACTAAAAATGCATATCAAACATTACCATAGGGAGCTCCGAAAGACCATGGGCAACACTCCTAAGGTTTTAGATTTAGCTTACGCCAGGACCAGGCCGAGCGAAGCGGAAATGAAACTGTTAAAACGTGAAGCGCAACAGAGGATCGTAAAAGTGAAGTTGCCGCGGCTGCAGAAGCGGGCGGAGGCGCCCCCGGAGCCGGCGGTCGCGCCGCCGCTCACGGCCGCCGAGCCCGCCGCCGCCGACGCGCCGCCCCGCCCCGTCGACTCGCCCAAGCTGCGGGACGCGCTCGTCCCCAGGCCGGCCAAGCGGCCGCGCGTGTTGCTGCCCGTGCGCAATAAAGAACCGGAGCCGACGCTGGACCCCGAGACTGTCGCGGACGACCCGCCTCCGCCTCTCGTCAAACTAGAAAACGCCGAAACCGAAGACGATCTACTCGTGCCGAAACAAGAGATACCCGATTGTGGCGCCTTGGACTTTGAAACCGCGATATCGACACACACCGTAGCGAAAATGGTGAACGGCGACGTGTGTAAAAGCGAGAAGAGGCGTAAGACTTTCGCTTGTATAGGGAAACTGACGAGCGAGGACGAGGAGTGGGCGGGGGGCTCCTCGGACACGCGCTCGAGCTACCCGAGCTGCGGCACGCCCGACTCGGCGCGCGCCGCCGCCGACGACCCCGCCGGCGACAACCACTCCGCCGCCGCGCACCTCTACATGTACACTGAGAACGGTGAGCGCATCAAGTTGGTCCGCATGAAGCGCGAGGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGCCTGTGCTGGCAGCACGCGCTGTGCCACAACATACAGCGCGAGGCCGAGGTGCCCGAGAAGTACACGTGCAGCATCTGCCTGAACCCGCGTCGCGGGCGGCGGCGGCAGCGGTTCATGCACGACCAGGACCGGCTGTACGAGGGGCTGCTGCCGGGCCCGGGCGGCGGGCGCGCCTGCGACGCGCTGCGCCGCGCGCACGAGCTGTCCGGCAACCTGCTGCGCATCGAGGACGCGCTGCACGCCGTGCGCGTCAACACGCGCGTCGCACAGACAAAGAACCATCCGAAACTGTACCTGTGGGCCAGAGATTGGGAATCTGTTGAATTATCCTTCGCTCAAGAAAAACTAAACTCTGAATATTCAGACCTGAATGTGATCATCAATAATTTGGGAAAGGAGAACTTGCCTATTAAGGAGGAGGATTTAAAAGAAATGGCCTTAGATATGAAGACTCCTCCTGATGAACCGGAGGAAAAATATTGCCCAGTGGAGAAAGAGAACCAAATTGGTCAGGGTGTACTGAGCGGGTTGCTGTCGAGTCCCGGCGCGGCGTCTCTGGACCTGCCCATCAGTGAATCAGAACTGGACAAGCTGGCTAAATCTGTGCATGAGCACGAGAGCAGGGCGCGGGTGCGCGCGCCGCAGCCCGAGGCCGCCATCGAGAACAGCGCGTGCCGCGCGCGCCTGCTGCGCCACATCCAGCGCTGCCACGCGCTGCTCGACCAGCGGCTCGACTCCATCGAGGCGCAAGTCGCAGAGCTAGAGTCGCAAGACGCGTCGCTCGAGGACGACGAGTCGCCGGAGTTCTGTCCGCGCGCCAAGCAGGCGCTGGTGATGATCGCGCGCGACCTGGACGCCATGGAGGAGCTCGGCATCGTCACCTAA
Protein Sequence
MCFRCKVISNIFMKMSDKEVIEIDRVTPTVNTSKESEAENVDAIKKYIEEQDIVLRCSSDKDAVNQIIKDTYKGDNKNNLDLELQLTLSNNSGVATRDCEIKQQTYNIGSESVYSEETTMSASPNPSSNDSLLELENEETLANQAAANLLSLGQNCIKMHINIKQKKCSDEIITNAHECTFKSNVNIDGNEELPDNVELHQQGGGQNNEKNIELNSTNISPKNSDNDLHLSKEETKIQKLENKDGNQKLLNISELQNKNRYSKDEKCQPSTLLHKLLTCTSKSSSEINNSILLDKDTKTVQENKEHGEESLSIATSVMDMILNNAEVAISKKNAGALSKQCLSPDKANSSVSLAIGSKVEAKDFCELWHPAQIVEVDCEEMEVLVQYDQQPKMHNEWISISSPRLRPISSIVTKPPSRPHTPMSEALTEPKVEDKMKVTFAVGERCLARWRDNRRFIATVQKDLGNGHYEVMFDDGFQWKCTLSRMYKLKEANGHQDYPRFGAGAAPPPVAAPLAATLDAPPAAPAPAAPPPLYHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKRKKLPTVDKESKSTFASVKEEIKNEIKSEPGTLSHESAQTAEPPLKETISETQVKKIIAKKLPVKKKTLGKKKIKLKNIDGKSVVSSSNDTKKEKIPEAVASIIGTVFANEPEVEVKAEPPDEEVMDANANDIKPDDLTNALDICSAEIKQDIDVVTEEETKPFEIQDGVKHEEVIGKIKEVITKLEDGINEVEKKEIKPEVVKEETVPEDVQPVVNPVETNDKEKQKKSKSSSKVKKGKKLRLMQEKKVKKQVEKVKCQLEEMKKQVEAMRQEIMLKTEQLASSRRGECAAPEAALLPGEWCARWLDGQPQGAVSEAPASGDSPLPRRSVMVEDKRLPPGWTKHMVRRSLGSSAGKWDVVLVSPENRRLHTKNDMRMYLENNPQPELKPFEAALMDFGIHLKLSRRLGWVRSSAEGAPPPPPPCRDLPASSPLLKRSKLSLNKNHHKLMHHKKRPRLKIKPLRPPPISEGPGLHQSSKETNMCSEPSVAEEAVLDGASIKDGFVDVGSLRVQVISTLLRCPAEGCFKNFRNTTLLKMHIKHYHRELRKTMGNTPKVLDLAYARTRPSEAEMKLLKREAQQRIVKVKLPRLQKRAEAPPEPAVAPPLTAAEPAAADAPPRPVDSPKLRDALVPRPAKRPRVLLPVRNKEPEPTLDPETVADDPPPPLVKLENAETEDDLLVPKQEIPDCGALDFETAISTHTVAKMVNGDVCKSEKRRKTFACIGKLTSEDEEWAGGSSDTRSSYPSCGTPDSARAAADDPAGDNHSAAAHLYMYTENGERIKLVRMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQREAEVPEKYTCSICLNPRRGRRRQRFMHDQDRLYEGLLPGPGGGRACDALRRAHELSGNLLRIEDALHAVRVNTRVAQTKNHPKLYLWARDWESVELSFAQEKLNSEYSDLNVIINNLGKENLPIKEEDLKEMALDMKTPPDEPEEKYCPVEKENQIGQGVLSGLLSSPGAASLDLPISESELDKLAKSVHEHESRARVRAPQPEAAIENSACRARLLRHIQRCHALLDQRLDSIEAQVAELESQDASLEDDESPEFCPRAKQALVMIARDLDAMEELGIVT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00410302;
90% Identity
iTF_00411481;
80% Identity
-