Csei006918.1
Basic Information
- Insect
- Cyaniris semiargus
- Gene Symbol
- PAX1_1
- Assembly
- GCA_905187585.1
- Location
- LR994550.1:480069-483776[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4.7e-49 1.1e-45 155.1 0.3 35 125 29 119 22 119 0.98 2 2 3.7 8.4e+03 -2.9 0.0 11 21 150 160 149 161 0.85
Sequence Information
- Coding Sequence
- ATGAGGCGATGCTGGCTGGCGCGGTGCGGAAGGGCGGGGAGTGATGATGATGAAGAAGGAGGCGTGTTCTGTCGAGGGTCACCAATGCCGTGCGACATCAGCCGGCAGCTGCGCGTGTCCCACGGCTGCGTGTCCAAGATCCTGGCGCGCTACCACGAGACCGGCTCCATCCTGCCCGGCGCCATCGGCGGCTCCAAGCCCCGCGTCACCACGCCCAAGGTGGTGTCGTACATCAAGCAGCTGAAGGCGAAGGACCCCGGCATCTTCGCGTGGGAGATCCGCGACCGGCTGCTGGCGGACGGCGTGTGCGACAAGTACAACGTGCCCTCCGTCAGCTCCATCAGCCGCATCCTGCGCAACAAGCTGGGCGGCGCCTACCCCGTGCCGTCCCTCTACCCCGCGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTACGTGTACCTGCAGGGCCGGCCGCACCCCCCGCACCTGCCCCCCGCGCCGCCCGCGCCGCACCACGCGCACGCGCACGCGCTCTGA
- Protein Sequence
- MRRCWLARCGRAGSDDDEEGGVFCRGSPMPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVSYIKQLKAKDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKLGGAYPVPSLYPAPPQRCWPLHQPYDYYVYLQGRPHPPHLPPAPPAPHHAHAHAL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00405873;
- 90% Identity
- -
- 80% Identity
- -