Basic Information

Gene Symbol
-
Assembly
GCA_015732765.1
Location
NC:205127491-205133073[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0002 0.0056 16.8 2.5 3 23 65 85 63 85 0.96
2 12 6.9e-07 2e-05 24.5 1.5 1 23 93 116 93 116 0.95
3 12 4.6e-05 0.0013 18.8 2.4 1 23 149 171 149 171 0.99
4 12 1.7e-06 4.8e-05 23.3 0.2 1 23 179 202 179 202 0.98
5 12 0.49 14 6.1 6.0 1 23 221 243 221 243 0.97
6 12 9e-05 0.0025 17.9 0.8 1 23 252 274 252 274 0.94
7 12 7.9e-06 0.00023 21.2 1.3 2 23 288 309 287 309 0.98
8 12 0.0039 0.11 12.7 0.3 1 23 317 339 317 339 0.94
9 12 9.9e-05 0.0028 17.7 0.2 1 23 362 384 362 384 0.98
10 12 1.3e-05 0.00037 20.5 2.0 1 23 392 414 392 414 0.99
11 12 1.9e-05 0.00054 20.0 4.1 1 23 430 452 430 452 0.97
12 12 0.12 3.6 8.0 0.2 1 23 460 482 460 482 0.96

Sequence Information

Coding Sequence
ATGGCCGAAATTACGGTGAAAACGGAGCCCGGTTACGAAATGCACTCCTCCCTGGAGGATCAGCAAACGCAGCAGGAGGAATCTAAGGCCACGACTTCTTTCTGTTACGAAACTGTGACGAAGGAAGAAGTAATACTGGAAGACGAATTTGTTTCACCAGAAGAGGAGAGCGCAACCAAGCAAGATATGTTTTGCGAAGAATGCAACAAATCGTTCACAAATCGAGCGCTTTTCAGAACTCACAAGTATAAACATAAGGTTGTCAAAGAGGGAAAGTATACCTGCCAAATCTGCGATAAGTGCTTTAGAGACAAATATGCTCTGACCATTCACCTGCAGGGCATTCATCTGGTGTCCAAGCTcactaaaaacaaaaagaacGAAGAATTGAACGAACCGGATGTTAAACAGTTTCCAAAAACCATCACGAACGAAAATGGACAATTCAAATGCACCGAGTGTGACGAGAGATTTGAGTTCCAGTACCTGCAGCAGCGACACATTCGAAGGCATTCGGCATTGAAGCAAGGGTTGTACAAGTGCGAAGAGTGCAATAAGGCCTTTGCTACGCCCAGTGAAATCAAAAGTCACCTCAAACGAGCTCACGAGAAACATGCACAGAAGAGTTCGGAAGTTTCCGTGCAGGAAGAGGATGGAGTGTTTATCTGCAGTAAATGTAACAGGAAGTTTGAGGAGCGACACTTGTGCCAGCAACATATTTTGAGACATTTGGCACTGATGAAGGAACGGGTTTTCACTTGCTCCAAGTGTCCTAAGaaattcatatcagaaaaatatctcgaaaaacaTGAAGCATGGCACGAAGTTAAAGCAGCTCGTGTCGAACAATGTGAAATGGTGAAATGCGACGAGTGTAACAGGGAATTCCGAAATAAGCTCCTGTTGTCTCGACATATTCGCAGGCACAAGCTCATAAAAGAAGGCAAATTCCTTTGCGAGATTTGTGACGCGCGATACACAGCCAAGCGGCAGTTGATGAAACACGCAGAGAAGCATAAGAAGAATCCGTACCTGCCGTCATTCGAGCCTCCCGTTGTAATTGAACGGAACAACCACAGCGCGTTCAAGTGTCCGGACTGTGGCATGGTATTCACCGTTCGACGTGCGTATGACAATCATGCGCAGAGGCATGTAAATTTACGAAATGGCACGTACAAGTGCGACATTTGTGAGAAGGTGTGCGGATCAGAAAACAATCTGTACAATCATATGCGGCGCCACCGAATTGGCGAAATAAAGGAAATTTCTGAGCCGAGAGATCTTCCGTTTGATTGTCCCAAGTGTGATAAGAAGTTTGGCAAGAAGCATCTTTTGAAAAGACACACCAAAGTGCACGAGGCGATAGAAAAGGGTCTCTACAAGTGCAAGACTTGTTTGAAGTACCTAGGATCATCTGCCTCGCTTGCGATACACGAACAGGGACACACTGGCAAGACCGCAAAGGATTAA
Protein Sequence
MAEITVKTEPGYEMHSSLEDQQTQQEESKATTSFCYETVTKEEVILEDEFVSPEEESATKQDMFCEECNKSFTNRALFRTHKYKHKVVKEGKYTCQICDKCFRDKYALTIHLQGIHLVSKLTKNKKNEELNEPDVKQFPKTITNENGQFKCTECDERFEFQYLQQRHIRRHSALKQGLYKCEECNKAFATPSEIKSHLKRAHEKHAQKSSEVSVQEEDGVFICSKCNRKFEERHLCQQHILRHLALMKERVFTCSKCPKKFISEKYLEKHEAWHEVKAARVEQCEMVKCDECNREFRNKLLLSRHIRRHKLIKEGKFLCEICDARYTAKRQLMKHAEKHKKNPYLPSFEPPVVIERNNHSAFKCPDCGMVFTVRRAYDNHAQRHVNLRNGTYKCDICEKVCGSENNLYNHMRRHRIGEIKEISEPRDLPFDCPKCDKKFGKKHLLKRHTKVHEAIEKGLYKCKTCLKYLGSSASLAIHEQGHTGKTAKD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00400833;
90% Identity
iTF_00400833;
80% Identity
-