Cqui006229.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Culex quinquefasciatus
Gene Symbol
KLHL18
Assembly
GCA_015732765.1
Location
NC:100928293-100935970[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1e-32 1.8e-30 105.1 0.2 1 108 29 134 29 136 0.97

Sequence Information

Coding Sequence
ATGGACACTGCTTGCGATGTATCTCCGGAGGAAAATTATGTCCTGTTCAAGCAGGACAGTCTATTTGCGGAAAGTTTTCCTTTGATGAAGGAGATCCGACGTCAGGGAAAACTGTGTGATGTTACTCTGAAGGTTGATAATCATTCCTTCTCCGCCCACCGAATTGTGTTGGCAGCTACAATTCCTTACTTTTATGCAATGTTTACTCACAACATGGCTGAAAGCAGGATCAAAGAAATCACAATGAAAGAAATTGAGCCACATGCTTTAGAAAGTTTGATAAATTTTGCCTACAGCGGGGTGGTCAAAATCGACAACCAAAACGTTCAAGGTCTTATGGTTGGAGCATCCTTTCTGCAGCTAAGTAAAGTCCGTGACGCGTGTGCGGATTTCCTGAAGAGCAGattCCATCCGCAAAACGTACTCGGAATACGACACTTTGCCGATACCCTTGGCTGCTCCCAATTGATGACCTCGGCCGACCGCTACATTCATCAGTATTTTTCCAAGGTTGCCACTTCGGACGAGTTTCTCGCGCTCAAATTTGAGGAGCTTATCGACATTGTGCGGCGTGACGAGCTCAACGATTCCGAAGAGCGCATTTTTGAAGCCTGTATGAAGTGGGTTAAAGTAGACCAAGAGACTCGCTCTGGATATTTGCCAAACATTCTGGCAAACGTACGTTTGCCCCTGTTGCCGCCCCAGTTTCTAGCAGATAATGTCGCCACCGAAGAGCTTATACGGACTTCGCACAAATGTCGGGATTTGCTGGACGAGGCTCGCGATTTTCACCTGATGCCGGAGCGCAGGGCACTCGTGTCGGCTTGCCGAACCAGGCCGCGCTGCTGTGATTATGTCGTGGGGCAAATATACGCCGTAGGAGGATTGACCAAAAATGGTGAATCGGTAAGCACAGTGGAAATCTACGATCCTATCACCAAAGAGTGGAAAATGGGAGAGGCAATGTCAATGTTACGATCCAGGGTAGGAGTAGCTGTGATGGATGGCAAGCTGTATGCATTCGGAGGATTTAACGGAACAGAGCGATTGTCTACTGTTGAAGTGTACGATCCCATGCAGAAAAAGTGGAGCCAAGggAAGGCAATGCGATGCAAGCGTAGTGCCGTCGGAGTGGCTGGGCTTGATGACTTGGTGTATGTGTGCGGAGGATATGACGGAGTTACTAGCTTGAGCACGGTTGAATGCTACTCTCCAAAAACGGACTCGTGGACGACAGTTGCACCCATGATGAAATACCGGTCTGCAGGCGGGGTAGCTCCACTTGGTGGGTATGTCTATGCGTTAGgTGGACATGATGGACTGTCAATTTTTGATTCTGTGGAACGATATGACGTAGCGAACAACACATGGACCAAgGTTCGTTCTATGTTAAGCCGACGGTGTCGCCTTGGTGTTGCAACTCTCAACGGAAAGCTGTACGCGTGTGGAGGATACGATGGTAGCTGTTTCCTACGATCGGTTGAAGTTTACACTCCAGAAAACGATCAGTGGCAGCTTATAGCTCCGATGAACGTGAAACGCAGCAGAGTTGCTTTGGCCGCCAACATGGGTAAACTTTGGGCTATTGGAGGATACGATGGAGAATCGAATTTATCTACAGTAGAAGTTTATGACCCGAAAACGGATACATGGACTTTTGTAGCACCGATGCGTCATCATGGAGGCGGTGTGGGCGCGGGAGTTATACCCAATGTAGTCATATAG
Protein Sequence
MDTACDVSPEENYVLFKQDSLFAESFPLMKEIRRQGKLCDVTLKVDNHSFSAHRIVLAATIPYFYAMFTHNMAESRIKEITMKEIEPHALESLINFAYSGVVKIDNQNVQGLMVGASFLQLSKVRDACADFLKSRFHPQNVLGIRHFADTLGCSQLMTSADRYIHQYFSKVATSDEFLALKFEELIDIVRRDELNDSEERIFEACMKWVKVDQETRSGYLPNILANVRLPLLPPQFLADNVATEELIRTSHKCRDLLDEARDFHLMPERRALVSACRTRPRCCDYVVGQIYAVGGLTKNGESVSTVEIYDPITKEWKMGEAMSMLRSRVGVAVMDGKLYAFGGFNGTERLSTVEVYDPMQKKWSQGKAMRCKRSAVGVAGLDDLVYVCGGYDGVTSLSTVECYSPKTDSWTTVAPMMKYRSAGGVAPLGGYVYALGGHDGLSIFDSVERYDVANNTWTKVRSMLSRRCRLGVATLNGKLYACGGYDGSCFLRSVEVYTPENDQWQLIAPMNVKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPKTDTWTFVAPMRHHGGGVGAGVIPNVVI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00400692; iTF_01383717; iTF_01277033; iTF_00440492; iTF_01168515; iTF_00133354; iTF_00451116; iTF_01350828; iTF_00334254; iTF_00285558; iTF_00753847; iTF_01265916; iTF_00245504; iTF_00424742; iTF_00812874; iTF_00363339; iTF_00643303; iTF_00160812; iTF_01224684; iTF_01288269; iTF_00211708; iTF_00210883; iTF_01164063; iTF_01276338; iTF_00092885; iTF_00102433; iTF_00095716; iTF_00109220; iTF_00103752; iTF_00101033; iTF_00104458; iTF_00105898; iTF_00096460; iTF_00107058; iTF_00093525; iTF_00103093; iTF_00101751; iTF_00108472; iTF_00097852; iTF_00094557; iTF_00097149; iTF_00100381; iTF_00105213; iTF_00098462; iTF_00099071; iTF_00106463; iTF_00717888; iTF_01519417; iTF_00118790; iTF_00235144; iTF_01011341; iTF_00014100; iTF_01383004; iTF_01382173; iTF_00793595; iTF_00203649; iTF_00694753; iTF_01181249; iTF_01318338; iTF_00426467; iTF_01049763; iTF_01461251; iTF_00240836; iTF_00324516; iTF_00628452; iTF_00693924; iTF_00310341; iTF_00664165; iTF_01054438; iTF_01183910; iTF_00455015; iTF_00664935; iTF_00724871; iTF_00456232; iTF_01053480; iTF_00672905; iTF_01052233; iTF_01456137; iTF_01521193; iTF_01541514; iTF_00202699; iTF_00937388; iTF_01431020; iTF_01454956; iTF_01460044; iTF_00322637; iTF_01127565; iTF_01415117; iTF_01043950; iTF_01457486; iTF_00984335; iTF_01432145; iTF_00999730; iTF_00176499; iTF_00644211; iTF_01458515; iTF_00311892; iTF_01297588; iTF_01300980; iTF_00313557; iTF_00974805; iTF_00976597; iTF_01223510; iTF_01540438; iTF_00351927; iTF_01375927; iTF_00316056; iTF_00877176; iTF_00991897; iTF_00312699; iTF_00453659; iTF_00311132; iTF_01300124; iTF_00665758; iTF_01044798; iTF_01256479; iTF_00797824; iTF_01378464;
90% Identity
iTF_00400692;
80% Identity
iTF_00400692;