Basic Information

Gene Symbol
Mbd3
Assembly
GCA_015732765.1
Location
NC:23255253-23257177[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.7e-25 5.2e-22 77.0 0.0 1 71 5 70 5 76 0.92
2 2 8.5e-05 0.25 10.7 0.0 24 74 108 181 103 184 0.85

Sequence Information

Coding Sequence
ATGAACGTTTCCATCGAGCGTAAACGCACGGACTGTGCGGCCCTGCCGAAAGGTTGGCAGCGGGAGGAGGTTCTCCGGAAAAGTGGACTGTCCGCGGGAAAGGTCGATGTTTACTATTACAGCCCAACCGGTAAGAAAATAGAAAGCAAACCCCAGCTGGCCCGCGTCCTCGGGGACACGATCGATCTGTCCACGTTCGACTACCAGGCGGGTCGCGTCGCGACGCACCTGATGCACAATGCCCTGAAGCGCAAGCTGGCCGGGTCCGGGTCCGGAAGTCCGACGCTTCCGCCGCCGGTTCCCATCTACAGCCAGCTGAGTTCGGGGTCGTCGGCGAGGCCGCACCAGGCGCAGCAACCGGACTACAGTCGCGGAATGCGCGCCGATACGTCCCTCATTCCACCGATTCGTCAGACGGCGTCCATATTTAAGCAGCCGGTAACGGTTGTGCGGTCCCAGGACGGCGAGGGCAAGGTTAAGCGAGATCTGCAGCACGGCACACAGGTTAAGCCCAAACAGCTGTTCTGGGAGAAGCGGTTGGAGAATCTGCGCGCCAACAACGTGTACAACGAGGAGATCGGTTCGCTCGAGCTTCCCAAGCGACTCAAATCCGTCGGTCCCGGCGTGAACGAGGCCACCGTCCTGCAGTCCCTCGCGACAGCCCTGCACCACAACACCCACCCGGTGACGGGACAAACCGCGTCCAAAACTTCACTCAACACGAACGCGGGGGTTTTTCTGAACCCGGACCAGCCGCTGATGCACGTGGCCACCGTCACCGAGGACGACATCAAGCGGCAGGAGGAGCGCGTCCAGTACGCCCGGCTGCGACTCCAGGAGGCGCTGCGGACGTAG
Protein Sequence
MNVSIERKRTDCAALPKGWQREEVLRKSGLSAGKVDVYYYSPTGKKIESKPQLARVLGDTIDLSTFDYQAGRVATHLMHNALKRKLAGSGSGSPTLPPPVPIYSQLSSGSSARPHQAQQPDYSRGMRADTSLIPPIRQTASIFKQPVTVVRSQDGEGKVKRDLQHGTQVKPKQLFWEKRLENLRANNVYNEEIGSLELPKRLKSVGPGVNEATVLQSLATALHHNTHPVTGQTASKTSLNTNAGVFLNPDQPLMHVATVTEDDIKRQEERVQYARLRLQEALRT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00948753;
90% Identity
iTF_00400567;
80% Identity
iTF_00400567;