Basic Information

Gene Symbol
Znf574
Assembly
GCA_964006125.1
Location
OZ023228.1:384298-388579[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 4.5 4e+02 2.1 4.8 2 23 234 256 233 256 0.96
2 21 0.032 2.8 8.9 2.7 1 23 324 346 324 346 0.97
3 21 0.0049 0.44 11.4 0.8 1 23 395 417 395 417 0.98
4 21 0.0012 0.11 13.3 0.3 3 20 472 489 471 491 0.95
5 21 0.12 11 7.0 2.7 1 23 503 526 503 526 0.97
6 21 4.1 3.6e+02 2.3 6.5 1 23 531 553 531 553 0.98
7 21 0.15 14 6.7 0.1 3 23 596 617 594 617 0.86
8 21 0.00011 0.01 16.6 0.1 1 23 623 645 623 645 0.97
9 21 3.4e-06 0.0003 21.4 3.0 2 23 681 703 680 703 0.96
10 21 0.0072 0.64 10.9 1.4 1 23 709 732 709 732 0.97
11 21 4.9e-05 0.0043 17.8 0.1 2 23 740 762 739 762 0.95
12 21 0.0026 0.23 12.3 0.6 3 23 772 792 770 792 0.92
13 21 0.027 2.4 9.1 0.1 2 20 861 879 860 879 0.95
14 21 0.017 1.5 9.8 0.1 2 23 899 920 898 920 0.96
15 21 1e-05 0.00089 19.9 1.1 2 23 941 962 941 962 0.97
16 21 7.9e-06 0.00071 20.2 0.5 1 20 987 1006 987 1008 0.95
17 21 0.047 4.2 8.4 0.8 2 23 1061 1083 1060 1083 0.94
18 21 0.008 0.72 10.8 0.6 2 23 1103 1125 1102 1125 0.92
19 21 0.16 15 6.7 0.3 1 23 1132 1156 1132 1156 0.97
20 21 0.036 3.2 8.7 0.0 1 23 1161 1184 1161 1184 0.96
21 21 0.0049 0.44 11.4 0.2 2 23 1219 1241 1219 1241 0.96

Sequence Information

Coding Sequence
atGGACGAAACGGTGGAAGTACGGAATGTCGAAAATCTTTGTAGATTATGTCTTTCCACCGACGAACCGCGATCTTCGATCTTCGGTGATCGTGCCGCGACGCTGTCGTTGGCCACgaaaattcacaattttttgtcTATCGAGatcTTAGCGAGCGATAAATTGTCAACGTCGATATGTGCCGAGTGCCTGATGAGAGTTAACAAATGGCAATCATACAAGGAGTCTTGTCTTCGCTCTCAGGAAAAATTGCAACGATGCCTCACGGAACGTGCCGAAACTATCCCTCACATCTCGAATATCAAGCCGGAGCCAATGGATTTCGACGAACCTCCGGGTTCGTTGGAAACGGTACCGCTGACCTCCGACGACGAATGGGAGAGTACAGTCGACGAGCGGAACGAATCCGCTGAGATAACAGTCTGCACACGTTCCGAGAAGCCAATATCTCCGCGGGACAGTGTGACCATAAAGCGCGAGGCGATTGAGGATGAGGAGAATCAGAACACAGAAATTGAATCGATATGCAGTACGGAGCTCCTCTTGAATCCAATGGCAGTGGCGACGACTAAAGAAGATCGCGTAATGGAAGCGGACTCGACGCAGAAGCTCTACAATCCGAAGAGTCTACGCGGCAAGAAGAAAAAGCTTCGTCGCGGTCCGGCGACGCATTATCGTGGGGCAAGAAAATTCAAGCAGCGTTGCAGCTTCTGCCAGATATATCTTCACTCGAAGCAGACGTACAAAAAGCACATGGAACGTTTTCACAGCGGAAAGAAGCCGGAAGCGAAGCCAAAGGTCGGGAAGAAGTTTACCAGTGTCGGAGCGTCGGAATCGACGAAATTCGTTGACGAGGCCGTCGAGGAGATCGAGGAAATGATCGAAGACGTTGAGGACGAATTGATAAGTTTGGAGAAAGATGCGCCATTAACGCCGGTGCAGCAAAACATAATAAGCCAACTGAAGACCTTCTCGTGTTACTCTTGTCAGCAGACCTTCAACGATCGTCGAAGTACGCTCAATCATATACGGCAGCATATGCCCGACCTGAGACCGTACACTTGCATAGCATGCCTCACGGAGTTCGCCGATCGTTCGATCTATAAGCTTCACTGCGGCGCTTCGTTTCAATGCGCGATGAAAATAGCTCTCGTAGTGCCGGAACACGGCACCGAGAAGTATTTCACATGCAACATGTGTCTCCGCCCGTTGTCCAACAGAAAGGAACTGTTGAGCCATTTGTCGAGACACTCGGACAAACAGTACGAGCAATTGGTCGGCGGACCATACCGTTCGCCGCCAAAGCTCAAGCCAATGGCGTCGCTTTCGGCCGTTTCGAGGGGAACTCGCGAAACGTCCGCGAACCGTATTCCAGTTCCTTACATGAACGGCGATCCTTCGCGCAATAATCTCTGCGATTATTGCGGTATGATATACAAACACAAACCAAATCTTATAAAACATCGTGAATACTGCAAGAAATTATCGCCCGACGAGCGAATATGCCATCGTTGCGTTCACTGCGGCGCAACGTTTATAGCATTCAACAAATTTCAAGGGCATCTAAAAACGatacacaagaaaaaaaattacgtgtgTTCGCACTGTTGTCTCGTGTTCAAAGAATCGAACGAGTATCTCGAACATCATCGACAGCATCGCGTCAGAGACAATCGTTTCGCGAGCATTTCCGGTGTCTCGGGTCGGACGCGAAAGATGAAAACGTGGGAAAACACCGCGGAAGAATCTAAAAATGATTCTTTCAAATCGTTGAATCGTTGGAGTTGCGCCCTCTGTCCGGCAAGTACATTCCCAACGAAGGCGCAACTCACCGAACATCGAAAGGTTCACCTAAAGTTAAAGATCTATTCGTGTTCGGTTTGCCGTCGTATGTTCGGACGCGTTTCGGATCTTGAGGCTCATATGGCGGAGCATGACGCGTCCGAAAGTCCGGCAAACACGTCGCAACCAATCGTTATTAAGTGCGACCCGAACGTCAGCAAAGACTCGATAAACTCTGATCCCGGACTCAGCAGTAGTGAGTGTCACACTTGCGGTAAGGTGTTCGCGAGTTATCACAATCTTCGCCGTCACGTGCGCAACGTTCACGAGGCACCGGGACGTTACAGTTGCTTCTCGTGTTCTAAGAATTTCAAAACGGAGGAGCATTGGATCGAACACGTGGAGACCGAACATCGACAGTTCGAAGGCTCAATTCGCTGCCCGCAGTGTACGGAAACGTTCGACACTGCGGAAAGCTTAACGGCCCATCGTCGTGAGATTCATGGCGCTGAAGGTGACGATCCACTTGCATGTTACATATGCGGAAAGGTTTTCCAGACGATAACCTCGTTGAAGATCCATCGCGGACATCATTTCCGCGTTAATTCGAGGCTCAGCATTGGAAACATTGCGACTAACGAGCCGAGAAGAAATGAGAttgaggacgacgacgatccTATCTCAATAGTTCCGACTGTGGCGCCATCGACGCCCCAATCGTCCCAAATTCCGGTTAAAGTTCCCAGAGCAAGAAAATCCTTTCCCAATAGTCCCGCAAGACAATTGCAGAACATATTGCAGTGTCAGGTGTGCGACGATCGCTTCAACGATGTCGCTAATCTCCGCAAACATCTGTGGGACGTTCATTGCGCTCGAAATAAGCCTGAGAAACCGTTTCAATCGACGAAACTTCAGTGTGAATTGTGTACCAATGTTTTGCCGGATGAAGAGAGTCTACGCAGTCACATGAAATGGCACGACAGCAATCCGATACTCGGCAACAACGTCGTCACCAAAAGGGAAGCGCAGACTCCAGCGGAGTGCGATATATGTGGAAAGTTCTACAGCTCTGGCAGTAATCTCAAGAGACACAAACAACGGCATAAAGAGCGAAATCATTCGGTTGCCATGGAATTTCCGAAGAACGCGAGAGGCGGACGCTGGGGTGGCGAAGGCTTCACCTGCAGCGATTGCCGGAAGGTCTTCGCGACGAATTCGACACTGAAGAAACATCGGGTTGTCTGCATGATGGCGCAACGCAAGTCCAACAATGGATCACTAAAGAGGCCGCGAGAGGCCCAGGTGATCAATCCTATTAGACCGAAATTCGACTTCGATGAGATCGTCGATCGGGCAACCAGCGCCTTCCACGATGGCAACGAAGCTAAGAAACCTGTTACCTGCAATCTCTGCCGAAAAATCCTTCCAAGTCGCGCGGAGCTTCACAAGCATCGCGTTAGAGTTCACAAAGTCACCAATGACGACGGTGTCGACCTCTATGGCGCTACGGATGATAATCATGTTTCCTGCGCGTCGTGCAACAAGATATTCTCCAATCTGGCGAACATGAAGCAACACTTTACGAAAGTTCACGCAAACAACGCGCCGCGTTATCCTTGCAGCGTCGAAGGATGCCGTATGGTTTTCCGAAGTTTCGTGGCTAAacgaaatcacgaaaaaacaCACGCAAACCTGTTGTACACGTGTCCTGTTTGTCCGAAACGAATGCCCACACGAGTGGCTATCAACGAACACATCGAACGCGATCACAAAGCTAACAGTTACGCTACGAACGCTAAGAAAGTCGAGAAGACGGcgaattttaagaaaatcaaTTTGGAAAATTACGTTGTTAAGGGAGCGAACGGCAGACAATGCCCGCTCTGCAAAATCACTTATCCGAACTTTAAGGCATTGAAGATTCATTATCTTAAGATACACGAAAACGTTGCTTAG
Protein Sequence
MDETVEVRNVENLCRLCLSTDEPRSSIFGDRAATLSLATKIHNFLSIEILASDKLSTSICAECLMRVNKWQSYKESCLRSQEKLQRCLTERAETIPHISNIKPEPMDFDEPPGSLETVPLTSDDEWESTVDERNESAEITVCTRSEKPISPRDSVTIKREAIEDEENQNTEIESICSTELLLNPMAVATTKEDRVMEADSTQKLYNPKSLRGKKKKLRRGPATHYRGARKFKQRCSFCQIYLHSKQTYKKHMERFHSGKKPEAKPKVGKKFTSVGASESTKFVDEAVEEIEEMIEDVEDELISLEKDAPLTPVQQNIISQLKTFSCYSCQQTFNDRRSTLNHIRQHMPDLRPYTCIACLTEFADRSIYKLHCGASFQCAMKIALVVPEHGTEKYFTCNMCLRPLSNRKELLSHLSRHSDKQYEQLVGGPYRSPPKLKPMASLSAVSRGTRETSANRIPVPYMNGDPSRNNLCDYCGMIYKHKPNLIKHREYCKKLSPDERICHRCVHCGATFIAFNKFQGHLKTIHKKKNYVCSHCCLVFKESNEYLEHHRQHRVRDNRFASISGVSGRTRKMKTWENTAEESKNDSFKSLNRWSCALCPASTFPTKAQLTEHRKVHLKLKIYSCSVCRRMFGRVSDLEAHMAEHDASESPANTSQPIVIKCDPNVSKDSINSDPGLSSSECHTCGKVFASYHNLRRHVRNVHEAPGRYSCFSCSKNFKTEEHWIEHVETEHRQFEGSIRCPQCTETFDTAESLTAHRREIHGAEGDDPLACYICGKVFQTITSLKIHRGHHFRVNSRLSIGNIATNEPRRNEIEDDDDPISIVPTVAPSTPQSSQIPVKVPRARKSFPNSPARQLQNILQCQVCDDRFNDVANLRKHLWDVHCARNKPEKPFQSTKLQCELCTNVLPDEESLRSHMKWHDSNPILGNNVVTKREAQTPAECDICGKFYSSGSNLKRHKQRHKERNHSVAMEFPKNARGGRWGGEGFTCSDCRKVFATNSTLKKHRVVCMMAQRKSNNGSLKRPREAQVINPIRPKFDFDEIVDRATSAFHDGNEAKKPVTCNLCRKILPSRAELHKHRVRVHKVTNDDGVDLYGATDDNHVSCASCNKIFSNLANMKQHFTKVHANNAPRYPCSVEGCRMVFRSFVAKRNHEKTHANLLYTCPVCPKRMPTRVAINEHIERDHKANSYATNAKKVEKTANFKKINLENYVVKGANGRQCPLCKITYPNFKALKIHYLKIHENVA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00397507;
90% Identity
iTF_00397507;
80% Identity
-