Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 3.5 2.7e+03 -1.9 0.0 21 31 10 20 3 26 0.81

2 10 0.0054 4.2 7.1 1.3 22 44 39 61 28 69 0.85

3 10 0.012 9.5 5.9 0.0 21 44 66 89 61 93 0.83

4 10 0.00055 0.43 10.2 0.1 21 44 94 117 82 121 0.80

5 10 0.14 1.1e+02 2.5 0.1 21 37 122 139 117 148 0.74

6 10 0.64 5e+02 0.4 0.0 21 43 150 172 142 177 0.82

7 10 0.0039 3.1 7.5 0.1 21 47 178 204 170 209 0.82

8 10 0.11 87 2.9 0.1 22 44 207 229 204 234 0.81

9 10 0.23 1.8e+02 1.9 0.1 21 43 234 256 229 261 0.85

10 10 0.02 16 5.2 0.1 21 44 262 285 251 290 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	3.5	2.7e+03	-1.9	0.0	21	31	10	20	3	26	0.81
2	10	0.0054	4.2	7.1	1.3	22	44	39	61	28	69	0.85
3	10	0.012	9.5	5.9	0.0	21	44	66	89	61	93	0.83
4	10	0.00055	0.43	10.2	0.1	21	44	94	117	82	121	0.80
5	10	0.14	1.1e+02	2.5	0.1	21	37	122	139	117	148	0.74
6	10	0.64	5e+02	0.4	0.0	21	43	150	172	142	177	0.82
7	10	0.0039	3.1	7.5	0.1	21	47	178	204	170	209	0.82
8	10	0.11	87	2.9	0.1	22	44	207	229	204	234	0.81
9	10	0.23	1.8e+02	1.9	0.1	21	43	234	256	229	261	0.85
10	10	0.02	16	5.2	0.1	21	44	262	285	251	290	0.77

Coding Sequence: ctgaagacacatcagcgcatacatagtggggagcggccatttagatgtgatgtgtgtaataagtcattcaataAGCTGTGTCTGCTGAAGATACATCAGCGTATACATAGTGGGGACCGGCCATTtagatgtgatgtatgtaatacgTCATTCAATAAGCAATGTAATCTGAGGAGGCATGAGCGTATACATAGTGAGGAGCGGCCATTTACCTGTGGTGTGTGTAGTAAGACATTCAGAGAGAAGGGTACACTGAAGTCACATCAGCACgtgcatagtggggagaagccatttagGTGTGATATATGTCATAAGTCATTTAATCGGCAacgtaatctgaagacacatcagcgcatacatggtggggagcagccatttggatgtgatgtatgtaacaaATCATTCAGTCGGCAGAGTTATCTGCagacacatcaacgcatacacagtggggagtggccatttagatgtgatgtatgtaataagttatTCGATCAGGAGAGTAAACTAAcagcacatcagcgcatacatagtggggaacgGCCATTCacatgtgatgtatgtaataagtcattcagagaGCAGACTGcactgaagacacatcaacatATACACAGTGGGAAGAAGCCATTTAgatgtgatatatgtaataagtcatttaatcGGCaaagtaatctgaagacacatcagcgcatacatagtggggagcggccatttagatgtgatgtatgtaacaagTCATTCAGAGAGCAGGGTacactgaagacacatcagctcgtgcatagtggggagaagccatttagGTGTGATATATGTGATAAGTCATTTAATCGGCAAAGTcatctgaagaggcatcagcgcatacatgttGATGTATGTAGTAAATCACAGAGCAGTAGTGATGGGTTTTGA
Protein Sequence: LKTHQRIHSGERPFRCDVCNKSFNKLCLLKIHQRIHSGDRPFRCDVCNTSFNKQCNLRRHERIHSEERPFTCGVCSKTFREKGTLKSHQHVHSGEKPFRCDICHKSFNRQRNLKTHQRIHGGEQPFGCDVCNKSFSRQSYLQTHQRIHSGEWPFRCDVCNKLFDQESKLTAHQRIHSGERPFTCDVCNKSFREQTALKTHQHIHSGKKPFRCDICNKSFNRQSNLKTHQRIHSGERPFRCDVCNKSFREQGTLKTHQLVHSGEKPFRCDICDKSFNRQSHLKRHQRIHVDVCSKSQSSSDGF

Sequence clustering based on sequence similarity using MMseqs2