Basic Information

Insect: Cryptocheilus praepositus
Gene Symbol: topi
Assembly: GCA_033815515.1
Location: JAWWQZ010000256.1:2811267-2813517[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 0.059 6.5 7.9 2.2 1 23 250 272 250 272 0.95

2 15 0.038 4.2 8.5 0.9 2 23 279 301 278 301 0.95

3 15 0.00094 0.1 13.6 0.5 2 21 308 327 307 328 0.92

4 15 9.8e-06 0.0011 19.8 0.8 1 23 335 357 335 357 0.97

5 15 6.4e-06 0.0007 20.4 2.8 1 23 363 385 363 385 0.96

6 15 0.043 4.7 8.3 2.2 2 23 397 418 396 418 0.94

7 15 0.00074 0.081 13.9 2.9 1 23 434 456 434 456 0.97

8 15 0.54 59 4.9 1.3 1 23 494 517 494 517 0.94

9 15 0.05 5.5 8.1 0.0 1 21 531 551 531 552 0.92

10 15 0.0079 0.87 10.6 0.0 1 23 557 579 557 579 0.98

11 15 2.1e-06 0.00024 21.9 3.1 1 23 585 607 585 607 0.98

12 15 0.00014 0.015 16.2 0.4 1 23 613 636 613 636 0.97

13 15 0.052 5.7 8.1 0.7 1 23 642 664 642 664 0.89

14 15 3.4e-07 3.8e-05 24.4 2.2 1 23 670 692 670 692 0.99

15 15 6.6e-06 0.00072 20.3 4.9 1 23 698 721 698 721 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	0.059	6.5	7.9	2.2	1	23	250	272	250	272	0.95
2	15	0.038	4.2	8.5	0.9	2	23	279	301	278	301	0.95
3	15	0.00094	0.1	13.6	0.5	2	21	308	327	307	328	0.92
4	15	9.8e-06	0.0011	19.8	0.8	1	23	335	357	335	357	0.97
5	15	6.4e-06	0.0007	20.4	2.8	1	23	363	385	363	385	0.96
6	15	0.043	4.7	8.3	2.2	2	23	397	418	396	418	0.94
7	15	0.00074	0.081	13.9	2.9	1	23	434	456	434	456	0.97
8	15	0.54	59	4.9	1.3	1	23	494	517	494	517	0.94
9	15	0.05	5.5	8.1	0.0	1	21	531	551	531	552	0.92
10	15	0.0079	0.87	10.6	0.0	1	23	557	579	557	579	0.98
11	15	2.1e-06	0.00024	21.9	3.1	1	23	585	607	585	607	0.98
12	15	0.00014	0.015	16.2	0.4	1	23	613	636	613	636	0.97
13	15	0.052	5.7	8.1	0.7	1	23	642	664	642	664	0.89
14	15	3.4e-07	3.8e-05	24.4	2.2	1	23	670	692	670	692	0.99
15	15	6.6e-06	0.00072	20.3	4.9	1	23	698	721	698	721	0.96

Sequence Information

Coding Sequence: aTGGCAGAGATACTGAAGACAGAATCCCTTAGTACATTAAGTGACAGAGAGGATGATATTGATGATCTGGATGGATCAGTTATTTGGTCTCAGGAAGAACCACTTTCATCAAATGAAATATTGGAGCTTGAGCCAGACACCACAGTAAAgacaaatcatttaatttcactcTGTCGATTATGCGCCGGACAAACAATCAAtccaatttacatttattctgAGTTTGGAGAATCCATGAGATTAGCAAACAAAATGAACACTTGCTTAAGCATAAAGGTGAGAAAGACAGATCCGCTGCCTAAACAACTTTGTCTCACCTGTGTTGAAAAAATAAACTGGTGTGACAATTTCGACACGCAATGTATCAAGGCGGAAGAAATCCTGTTGACAATGTTAAAACAGAAGCAGTCACTTGACGTTTCTGAATTTGTAGCAGATCCATTAAGCGATCCTAAGTCATGCCCATTGTGTCCAGAAGGACACATGGCTACCTGTGAAGAAGTCATTGAAAACCCAGATGACAAAGAACTCTATGACAGCGACGTCGTTTTGGACAGCAGCGACGAAGAGAAGATATTCAACGAAGCTAAAGTCGACACCGAAACAGGCAACAAAGCTATAATCTTACAGTGCCTCGGTAGCAAAGAAAAGTACCTAAAATGCGGCGCCTGCATGAATCTATACCACACGAAAGAGACTCTGGACGGTCACAAGTGCAAACCCAACATACAAAACACCTCGAAACCCTACAGATGCGACACGTGCAACGTCACCTTCACATTTGAGGAGCGACTCAACTTCCACATGCAATTTCACGAGGGCGCAAAAGCACTGTACTGCGAGATCTGTAACATCACATTCGGCAAGGAATTAAAGCTATTCTACCATTACAAACGGTACCACTGCCAGGACGTCACCGTGTCCTGTCTGCAGTGTGGCAAATTGTTCGAGAATCAATCCCAGCTTCGCTTGCACGTGTGCGTCGACGGCAAAACTCGCCCTCACGTGTGCGAGGTCTGCAATAAAGGGTTCTCTGACGGGTATACTTTAAAGCGGCACATAGTCACGCATCTGCCAGAGAAGCCATACAAGTGCTCTCAGTGTTCAAAGAGCTTTACGCAGAAGTCTCGCTTGAACAAGCACACTGCCGGACACGGGGTTGTCATAGAGAACAGCCAAAGTGTCTGGAAGTGCGTACAGTGCGGCGAAGTCTTCAATTCCTGCGACGACGCCTGTACCCACTTCGGGACCCACAAGGACAAGGTCACGTTGATAGAGCAGCAGCTCACTTCCAAGGTATACCATTGCGAGTTTTGCAACAGTTACTTCACCGACATTAGCAACCTAAAGGCCCATCAGAATCAGCACGTTGTCGAAAAACCATACAACTGCAATCTCTGTGCAACCGTGTACAAATGTTTTGCGGAAGCGATTCTGCACTGGAAGGAGCATGCGAGGGTGTTCAAGATATTGACAGTATTCCTGTGCGATGTCTGCAGCAAAGACATGAAGGAACTGTCGCTGCTTTATAAGCACAAGCAAAAGAGACATCCGCATGCCCCGAGAAAGTCGGAAGCCGGGGTCCCGAAGTTCATATGCGAGCTTTGCGGAAATGTCTTTGACAAGAAGGAAGAAATACAGGAGCACGGACGGGATCAGTGCTCGAAGTTCCCTTGCGACATTTGTGGGAGTCTATTGCCAACGGCGAATGCCCTCAACGCGCACAAGAGAAGGCACAGTGGCCTGCGCCCGTACGTTTGTAATATTTGCGGGAAAAGTTACACGCAGTCGAGTCATATGTGGACGCATAAGAGATTCCACATGGGTGTGAAGCCGTACGCTTGCGAGTACTGCGATCAGAGATTCACCATAAAGCCCGATTTGGCTGATCATACGAGGAAGAAGCATACTAGGGAGAGGCCGTTTAAGTGTGACGTTTGTAACAAGGCGTTCCTGACGGGTTCCGTTTTTTATCAACATCGGCTGATACACAGAGGCGACCGTAGGTATAAGTGCCATTATTGCGAGAAGGCTTTTACGAGGACGGAGGCGTTGAATAATCACATCAAGATTCATACTGGCGAGAAACCGCATGCGTGTGACGTGTGCGGACGATGCTTCAGGCAGAAAGGTGATATGAGGAAGCATAGGCGGACGCAGCATACTGCCAAACAAGAATAG
Protein Sequence: MAEILKTESLSTLSDREDDIDDLDGSVIWSQEEPLSSNEILELEPDTTVKTNHLISLCRLCAGQTINPIYIYSEFGESMRLANKMNTCLSIKVRKTDPLPKQLCLTCVEKINWCDNFDTQCIKAEEILLTMLKQKQSLDVSEFVADPLSDPKSCPLCPEGHMATCEEVIENPDDKELYDSDVVLDSSDEEKIFNEAKVDTETGNKAIILQCLGSKEKYLKCGACMNLYHTKETLDGHKCKPNIQNTSKPYRCDTCNVTFTFEERLNFHMQFHEGAKALYCEICNITFGKELKLFYHYKRYHCQDVTVSCLQCGKLFENQSQLRLHVCVDGKTRPHVCEVCNKGFSDGYTLKRHIVTHLPEKPYKCSQCSKSFTQKSRLNKHTAGHGVVIENSQSVWKCVQCGEVFNSCDDACTHFGTHKDKVTLIEQQLTSKVYHCEFCNSYFTDISNLKAHQNQHVVEKPYNCNLCATVYKCFAEAILHWKEHARVFKILTVFLCDVCSKDMKELSLLYKHKQKRHPHAPRKSEAGVPKFICELCGNVFDKKEEIQEHGRDQCSKFPCDICGSLLPTANALNAHKRRHSGLRPYVCNICGKSYTQSSHMWTHKRFHMGVKPYACEYCDQRFTIKPDLADHTRKKHTRERPFKCDVCNKAFLTGSVFYQHRLIHRGDRRYKCHYCEKAFTRTEALNNHIKIHTGEKPHACDVCGRCFRQKGDMRKHRRTQHTAKQE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01255863;
90% Identity: iTF_01255863;
80% Identity: -