Cpra013219.1
Basic Information
- Insect
- Cryptocheilus praepositus
- Gene Symbol
- pax6
- Assembly
- GCA_033815515.1
- Location
- JAWWQZ010000257.1:4783604-4785171[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5.5 1.4e+04 -3.6 0.0 23 42 3 22 2 24 0.71 2 2 2e-70 5e-67 224.0 0.3 1 118 63 180 63 184 0.98
Sequence Information
- Coding Sequence
- ATGTTGAAGGCCAAAATCGTAGAATTACTCATCGTCACCTGCCGCGGACTAAACACCGCCAAGCAACTTTGGCTCTTTAGTCTGAAGCAAAATGATAAAAAGGAGGACCTGATGCACGGGGGTGGCGCGGGCATCGGCGGAGGCTCAATGGTCGGGCAAAACTCGATATTTGGCTGCTCCGCAGCGGGACACAGCGGTGTCAATCAGCTCGGTGGCGTTTATGTCAATGGCCGCCCATTGCCGGACTCCACCAGACAGAAGATCGTCGAGTTGGCGCACAGCGGGGCCAGGCCGTGCGACATATCGAGGATCTTGCAAGTCAGCAATGGATGTGTCTCCAAGATACTAGGCAGGTACTACGAGACCGGCTCGATAAAGCCGCGGGCGATTGGCGGTAGCAAGCCCAGGGTGGCCACGACGCCGGTGGTCAACAAGATAGCTGATTACAAACGCGAGTGTCCCTCGATTTTCGCCTGGGAGATCCGGGACCGATTGCTGCAAGAAGGTGTCTGCAACAACGACAACATACCGAGCGTGAGTATCAAGTCATTTTCGTAA
- Protein Sequence
- MLKAKIVELLIVTCRGLNTAKQLWLFSLKQNDKKEDLMHGGGAGIGGGSMVGQNSIFGCSAAGHSGVNQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVNKIADYKRECPSIFAWEIRDRLLQEGVCNNDNIPSVSIKSFS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- iTF_00762498; iTF_01228964; iTF_00864582; iTF_00127401; iTF_00182569; iTF_00125869; iTF_00865261; iTF_00183888; iTF_00129689; iTF_01169114; iTF_00222473; iTF_01409048;
- 80% Identity
- -