Basic Information

Gene Symbol
Bcl11a_2
Assembly
GCA_963576515.1
Location
OY754956.1:5542879-5543885[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 0.12 75 3.8 1.0 25 39 66 80 49 92 0.72
2 5 1.4 8.2e+02 0.4 0.1 24 44 95 115 88 119 0.77
3 5 0.0022 1.3 9.4 0.2 22 48 121 147 115 151 0.85
4 5 0.00011 0.064 13.6 0.0 21 52 148 179 145 179 0.90
5 5 0.0027 1.6 9.1 0.0 20 48 175 203 172 206 0.90

Sequence Information

Coding Sequence
ATGGAGGACAGCGAGGAGTTCCGGAGGAGCCTCGAGCCGATGGTCATCatcgacgacgacgaggccGTGCACGAGGGGAACTTCCGCGAGGCGTCGCCCCACCGCCCCCACGTCCCGCCCGAGATCTCGATAATCCCCGTCGCGCCGTCCGGCAAGCGCGGCGCCGCGCCGCCGAACCGCCGGTCGAGCCCGCTCGAGAAGTGCCCGATATGCAAGAAGTTCTTCAGGCGGATGAGGACGCACCTGCTCAAGCACGAGATGAACAGCAGGCCGCCCGAGGACAGGTTGTGCTGCCCCTTCTGCAAGAAGATGTTCAACACGCAGAGCAACATGGCGATCCACATGAGGACGCACACCGGCGACAAGCCCTACGTGTGCGACGTGTGCAGGAAGTCCTTCTCGCAGAGCTGCAACCTCGTCAACCACCTACGGGTCCATACCGGCGAGAAACCGTTCAAGTGCCCGTACTGCGAGAGGGCGTTCACGCAGTCCGGCAACCTGAACAACCATGTCAGGCTGCACACGTCGGAGAAGCCGTTCGAGTGTCACTTCTGCGACAAGGCGTTCGTCCAATCGGGCAACCTGAACTCGCACATCCGGAACAACCACAAGGGGGCGTCGTCGGAGGGGGACCGGCGCGTCGGGTTGGCGGCGTGGAAGATGGCGGACGCCGGGGGACATATCTAG
Protein Sequence
MEDSEEFRRSLEPMVIIDDDEAVHEGNFREASPHRPHVPPEISIIPVAPSGKRGAAPPNRRSSPLEKCPICKKFFRRMRTHLLKHEMNSRPPEDRLCCPFCKKMFNTQSNMAIHMRTHTGDKPYVCDVCRKSFSQSCNLVNHLRVHTGEKPFKCPYCERAFTQSGNLNNHVRLHTSEKPFECHFCDKAFVQSGNLNSHIRNNHKGASSEGDRRVGLAAWKMADAGGHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00392139;
90% Identity
iTF_00393052;
80% Identity
iTF_00393052;