Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.17 1e+02 3.3 0.0 32 45 104 117 83 125 0.84

2 7 0.73 4.4e+02 1.3 0.0 19 45 119 145 117 153 0.84

3 7 0.44 2.6e+02 2.0 0.0 23 44 151 172 145 177 0.88

4 7 0.054 32 4.9 0.0 21 46 177 202 173 205 0.90

5 7 0.00099 0.6 10.5 0.1 21 48 205 232 201 236 0.86

6 7 0.17 1e+02 3.3 0.3 22 46 234 258 229 260 0.91

7 7 0.032 19 5.6 0.1 22 45 262 285 259 289 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.17	1e+02	3.3	0.0	32	45	104	117	83	125	0.84
2	7	0.73	4.4e+02	1.3	0.0	19	45	119	145	117	153	0.84
3	7	0.44	2.6e+02	2.0	0.0	23	44	151	172	145	177	0.88
4	7	0.054	32	4.9	0.0	21	46	177	202	173	205	0.90
5	7	0.00099	0.6	10.5	0.1	21	48	205	232	201	236	0.86
6	7	0.17	1e+02	3.3	0.3	22	46	234	258	229	260	0.91
7	7	0.032	19	5.6	0.1	22	45	262	285	259	289	0.91

Coding Sequence: ATGAGCTACACCTGCGATTGGTGCATGCAAGAAGCGCCCGTGCAGAGGATCGATGAGAGGTTATggcgattttggaaaataatcagcGAGGAGGATCCCACGGTAGCGTCCCGTAAGAGCATCTGCGAGGCCTGCAGGTCGCGCTACGAGGAGTTCTCGTCGTACGTCGAGGCGTGCAAGCTGCACGCCTCGATCGTCGAGAGGGCGCCGACGGTCGGGCGGTTCGAAGACCGACCCCCGATCGAGGAGGAACGCTCGAGCGATCCCGCGCCCCTTCCGCGCCTGCGCCTCGAGCGCTCGCACTGCGACAAGACGTTCGGCCAGTCGGGCAGCTTGAGGCGACACCTGCGCAGTTCGACGGGCGAAAAACCTTTTAAGTGTACCCGCTGCGATAAGACTTACGTCCACGTGGGGAACTTGAGGATCCACACGCGCGTCCATACGGGTAAGAGGCCGTTCAAGTGCTCCTTCTGCGATAAGACCTTCGGCGATTCCGGTAACTTGACGAAGCACATGCGCACccatacgggcgagaagcctttcAAGTGTCTCTTCTGCGATAAGTTCTTCAGCGGGTCTTGCAATTTGAAGAATCACCTGCGCATCCACACGAAAGAGGCTCCCTTTAAGTGTTCCGTCTGCGACAAGACTTTCACTCAGTCCAGCAACCTGAAGAGCCACATGCGCGTGCACACGCTCGAGAGGCCTTTCAAGTGCTCGTGCTGTGCTAAGGCGTTCAATCACTCGACCAGTTTGAAGAACCACCTGCGCATCCATACCGGCGAGAGGCCTTTCAAGTGCTCCCGCTGCGCCAAGACCTTCAATCAGTCCGGTAGTCTGAACAGGCACGTGCGCATGTGCGAGAAACGTTTTTAG
Protein Sequence: MSYTCDWCMQEAPVQRIDERLWRFWKIISEEDPTVASRKSICEACRSRYEEFSSYVEACKLHASIVERAPTVGRFEDRPPIEEERSSDPAPLPRLRLERSHCDKTFGQSGSLRRHLRSSTGEKPFKCTRCDKTYVHVGNLRIHTRVHTGKRPFKCSFCDKTFGDSGNLTKHMRTHTGEKPFKCLFCDKFFSGSCNLKNHLRIHTKEAPFKCSVCDKTFTQSSNLKSHMRVHTLERPFKCSCCAKAFNHSTSLKNHLRIHTGERPFKCSRCAKTFNQSGSLNRHVRMCEKRF

Sequence clustering based on sequence similarity using MMseqs2