Basic Information

Gene Symbol
Bcl11a
Assembly
GCA_946251935.1
Location
CAMIUL010000265.1:205309-206472[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 0.025 47 4.5 0.5 25 39 74 88 58 98 0.68
2 5 0.47 8.7e+02 0.5 0.1 25 44 104 123 97 127 0.78
3 5 0.0016 2.9 8.4 0.2 22 46 129 153 123 155 0.89
4 5 4.6e-05 0.085 13.3 0.1 21 52 156 187 154 187 0.90
5 5 0.0011 2 8.9 0.1 20 48 183 211 180 214 0.90

Sequence Information

Coding Sequence
ATGGAGGACAGCGAGGAGTTCCGACGCAGTCTCGAGCCGATGGTCATCATCGACGACCAAGACGACGACGAGGGGGCCGTGCACGAGGGGAACTTCCGGGACTCCTCCCCCGAGCGTCCCCAGATCTCCATAATACCCGTCGTTACGACAGCCACCACTCCGCTCATTACCAGGAAGAGGGAGAAGGGGGCGTCGTCGGTACGACGGTCGAGCCCGCTCGAGAAGTGCCCGATATGCAAGAAGTTCTTCAGGAGGATGCGGACCCATCTGCTCAAGCACGAGATGGACAGCAGGCCGCCGGAGGACAGGTTATGCTGCCCGTTCtgcaagaagatgttcaacacgcagagcaacatggcgatccacatgaggacccatacgggcgacaagccgtacgtctgcgacgtgtgccgcaagtcgttctcgcagagctgcaacctcgtcaaccacctccgcgtccacaccggcgagcgaccgttcaagtgtccgtactgcgaacgggccttcacgcagtccggcaacctgaacaaccacgtcaggctgcacacgtccgagaagccgttcgagtgccacttctgcgacaaggccttcgtccaatctggcaacctgagctcgcacatacgcaacaaccacaggtcggcgtgGAACGGACATATCTAA
Protein Sequence
MEDSEEFRRSLEPMVIIDDQDDDEGAVHEGNFRDSSPERPQISIIPVVTTATTPLITRKREKGASSVRRSSPLEKCPICKKFFRRMRTHLLKHEMDSRPPEDRLCCPFCKKMFNTQSNMAIHMRTHTGDKPYVCDVCRKSFSQSCNLVNHLRVHTGERPFKCPYCERAFTQSGNLNNHVRLHTSEKPFECHFCDKAFVQSGNLSSHIRNNHRSAWNGHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00392139;
90% Identity
iTF_00392139;
80% Identity
iTF_00392139;