Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 2 4e+03 -1.3 0.4 59 66 4 11 2 15 0.63

2 5 0.29 5.7e+02 1.4 2.8 6 19 18 31 13 47 0.71

3 5 0.39 7.9e+02 0.9 0.8 51 64 46 59 29 65 0.78

4 5 0.2 4e+02 1.9 0.1 6 22 52 68 47 80 0.73

5 5 1.5e-24 2.9e-21 76.0 12.9 1 69 224 292 224 293 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	2	4e+03	-1.3	0.4	59	66	4	11	2	15	0.63
2	5	0.29	5.7e+02	1.4	2.8	6	19	18	31	13	47	0.71
3	5	0.39	7.9e+02	0.9	0.8	51	64	46	59	29	65	0.78
4	5	0.2	4e+02	1.9	0.1	6	22	52	68	47	80	0.73
5	5	1.5e-24	2.9e-21	76.0	12.9	1	69	224	292	224	293	0.97

Coding Sequence: ATGGCAAACTGTCATTATTGTAACAGCATTTTAACTAAAAACTGTTCTGTTTTGAAATGCAGTCACTGTCATAAAGTAGTGCATGCTACGACTGCATGTAGTGCATTAAGTACTGAGCAGCTAGCTGCTCTTAAAGCCACTGAGAATTTCGAGTGGAGGTGCAATGACTGCAATCAAAATTCTTCACCTAGAAGCAAGGACGAAGATGATGAGATTAAAAGGATAGGAGCCAACATCGTTATTGAAAAATTAAAGCAAGACTTGAGAAAAGAGGTAACCAGTATAGTAACGGAAGAAATGCGGTCGGTTTCAGCATCGGTGCAGTGTTGCAGCCAGAAGATAGATGAATTTGCGGAATCCATTGATCTTTTAACAGGAAAAGTGAAGGATATGGACATGAAAGTGGACCAAGTGGAAAACCATAATAAGGATCTAGAAATCAAAATAGAATCTCTAGTGCAACACAGTAATGAAACAGAACAACAGCTGTTGGTCGACCATGTTGAAAAAGCAGCAAAATCGGGTATGCCTGCTCCAACACAAGTCATTACTTCACCACCAGGGTATACTCCTCCAACTATGGGTCCTCAACAAGCACCTCCGCCGGTGGTAGGCGTCAACGTCGTACCCACCGTCGGCGGCTCCTTGGTCGTCACAGTACAGATGGGACCGAATCCCGCGAGAATCGTCTGCAAGTCGTGTAATCAAGAAATCGTCACAAAAACCAAACCAAAAGCTTCGATGAGGACCCATCTGATAGCTGCTATATTCTGTGTTACTTTATTATGGCCCTGTGTTTGCATCCCGTACTGTACCAACTCTTGCCGGAACACTGAGCACTACTGCCCACACTGCGACGCATACATCGGATCTCACATCAACTAA
Protein Sequence: MANCHYCNSILTKNCSVLKCSHCHKVVHATTACSALSTEQLAALKATENFEWRCNDCNQNSSPRSKDEDDEIKRIGANIVIEKLKQDLRKEVTSIVTEEMRSVSASVQCCSQKIDEFAESIDLLTGKVKDMDMKVDQVENHNKDLEIKIESLVQHSNETEQQLLVDHVEKAAKSGMPAPTQVITSPPGYTPPTMGPQQAPPPVVGVNVVPTVGGSLVVTVQMGPNPARIVCKSCNQEIVTKTKPKASMRTHLIAAIFCVTLLWPCVCIPYCTNSCRNTEHYCPHCDAYIGSHIN

Sequence clustering based on sequence similarity using MMseqs2