Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.9 6.1e+03 -1.7 0.1 58 66 11 19 3 22 0.63

2 3 5.6e-15 3.8e-11 43.9 2.3 4 68 104 167 101 169 0.91

3 3 3.8 2.6e+04 -3.7 1.6 5 11 314 320 311 321 0.64

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.9	6.1e+03	-1.7	0.1	58	66	11	19	3	22	0.63
2	3	5.6e-15	3.8e-11	43.9	2.3	4	68	104	167	101	169	0.91
3	3	3.8	2.6e+04	-3.7	1.6	5	11	314	320	311	321	0.64

Coding Sequence: ATGATAGAGGAGAAATCGTATATAGTGACTTGGTGCTCAATATGTGATAAGCAAGTAAACATCGAGGAACGAGACTTTTCACACATTCGTAAATATCATCCCGAGATTGCTGGTAAATATTTGAACAATCAGAAAGCAGCGCGCTTTTGTAAATCACAAAGGGCGGAATGCAAGCGGAGCGGGCCGTCGCAAAGTGGCATGTTGTTCCCGTGGATTCCGACGTCGAAAGCACCCGATGGTAAAAGTCGCGCGCCGAAACAACCGAACAATGTCTTCTCCACAGAAGTTGAAATATGGAAATATCACAATGAATCAGTTCGTTGCCCTGCGTGTGGTGTGAAGGAGGTGCCGATAATACTAAAGCAGCAGAAATTCATGAGCTCCCGTTTTGCTGCATTTTGTTTAATGGgGTGCTGGCCGTTCTGCTTCATACCGTTGCTGATGAGACGGGACAAAAGCGTGCGCACGCTGTGCCCACGTTGTGGCTACGATTACGGGATTCGTAAGCGAGCAAAGAGTAAGCTGATAGCCTGTTCGCACGAATGCGCGTCTAGCTGTAGGAATTTCGCAAATTCACAACCGCGTTATTTTCGGGCGGAGTGCGGCGGCTCGCAAATGCAATCAGAATATCGCCAAAAAACACTTTCCATGGATGACGAGGCTGCGAGAGCTCTCAGGGTCTCGGAGGAGCGTCCTCGGAGAGAAGAAAGCAGATCTCGTCGCTGTCGATCGCAATTGAAGTTATCGCACGGATACGTCTTTTGTGCAAACCAGGTCATGAATTGCAGTTCACCAAATGATAAATGCAGTAGCGACGACTGCATGGACAAAAGATGGGATCGTCGGCGCGACCTGGACGAATCGAAAGCTCGGAAAGCTCGGGAACAAAGCAAATCCGAAGGCAGCACGGGGACAGCGACGGTCGATTTTTATGCAAGACAGGTTTGCTGCCAGGAGTGCGGCTAG
Protein Sequence: MIEEKSYIVTWCSICDKQVNIEERDFSHIRKYHPEIAGKYLNNQKAARFCKSQRAECKRSGPSQSGMLFPWIPTSKAPDGKSRAPKQPNNVFSTEVEIWKYHNESVRCPACGVKEVPIILKQQKFMSSRFAAFCLMGCWPFCFIPLLMRRDKSVRTLCPRCGYDYGIRKRAKSKLIACSHECASSCRNFANSQPRYFRAECGGSQMQSEYRQKTLSMDDEAARALRVSEERPRREESRSRRCRSQLKLSHGYVFCANQVMNCSSPNDKCSSDDCMDKRWDRRRDLDESKARKAREQSKSEGSTGTATVDFYARQVCCQECG

Sequence clustering based on sequence similarity using MMseqs2