Clev007601.1
Basic Information
- Insect
- Crematogaster levior
- Gene Symbol
- ewg_1
- Assembly
- GCA_901521435.1
- Location
- CABEGB010000783.1:17983-27751[+]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.8e-113 4.7e-109 363.9 0.1 1 212 52 262 52 263 0.98 2 2 0.98 1.7e+04 -3.8 0.0 99 126 290 317 273 320 0.67
Sequence Information
- Coding Sequence
- atgGTGTCTGTGCAAGACGCTGAGACCAGCACGTTGCGCAGACTTTcagacgatgacgatgacgagcCTAGTAGTGGGTCTGAAACCTACGAAGAAGGAGATCTCCTCTCGGCTGCGATGGATGACGATGTGACAGCTCAACTCGCTGCAGCAGGACCTGTAGGGGTTGCTGCAGCTGCTGCCATTGTATCagccaaaaaaagaaaacgaccTCACAGTTTTGAAACCAATCCCAGTATCAGAAAGAGACAACAAAACAGACTTTTAAGAAAGCTTAGACAAACTATTGATGAATTTGCTACGCGAGTAGGACAACAGGCAGTAGTATTAGTAGCTACGCCAGGGAAACCAAATAGTAGTTACAAAGTGTTTGGAGCAAAGCCATTGGAAGATGTAGTTAAAAATCTAAGAAACGTTATTATGGAGGAGTTAGAAAACGCACTTGCACAACAAGCACCGCCGCCTGTGCAGGACGATCCGTCATTATTTGAATTACCACCGCTTATAATCGACGGCATACCGACTCCAGTAGAGAAGATGACACAGGCACAACTTAGAGCTTTCATCCCGTTGATGTTAAAGTATTCCACAGGCAGAGGCAAACCTGGTTGGGGAAGAGATAGTACACGACCTCCTTGGTGGCCCAAGGAATTGCCTTGGGCTAACGTCCGGATGGATGCTCGATCGGAAgacgaaaaacaaaaaATCTCCTGGACTCATGCGTTACggcaaattgtaataaattgttataaatatcacGGAAGAGAAGATCTTCTGCCAGCGTTTAGCGAAGATGACGACAAGTCTAATGTTCTAATACAACAAGCGACACCTCATTCCTCGTCGCATGCATCATCGAGTCAGGGGCAAAATGGAGGAGGACAATCACAACAGCAGCAGACGaTGACGGCCCAGTATCCAACAACTGTACTGCAGACAATAACCAATCCAGATGGAACAGTTTCTATTATACAGGTGGATCCTAATACACCGATTATTACATTACCAGACGGTACAACAGCCCAAGTTCAAGGAGTCGCTACTATCCATACGAGTCAAGGAGATGTGCAAGCATTAGCGGAAGTAGCTGGTAGCACAGAAGGTGCTAGTGTGGCTGTCGATTTGAACACTGTCACAGAAGCGACGTTAGGTCAAGACGGCCAGATCATCCTTACTGGAGAAGACGGACACGGATATCCTGTCTCAGTCTCAGGAGTGATCACAGTGCCAGTGTCTGCCAGCATGTATCAAACTATGGTGGCCAATATACAGAGCGATGGTACGATGCAAGTGGTGACGCCGATGGTTCAGGTACCCAAGGTCGAGTCAGGAAACGGGGACACCACTATCGAAGCTGTCGCTATACAAGGCCACCCTATGACTATGATAAATGCCGCTGGGGAACATCAAGTTCTTCAAGTAATATCGTTAAAGGACGCCAACGTTCTGACGAAGGCCATGCAGGCCGATGTTGTTAAGGACGAGGACagtcaacaacaacaaactGTATCTAGCCCAGAATAA
- Protein Sequence
- MVSVQDAETSTLRRLSDDDDDEPSSGSETYEEGDLLSAAMDDDVTAQLAAAGPVGVAAAAAIVSAKKRKRPHSFETNPSIRKRQQNRLLRKLRQTIDEFATRVGQQAVVLVATPGKPNSSYKVFGAKPLEDVVKNLRNVIMEELENALAQQAPPPVQDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRDSTRPPWWPKELPWANVRMDARSEDEKQKISWTHALRQIVINCYKYHGREDLLPAFSEDDDKSNVLIQQATPHSSSHASSSQGQNGGGQSQQQQTMTAQYPTTVLQTITNPDGTVSIIQVDPNTPIITLPDGTTAQVQGVATIHTSQGDVQALAEVAGSTEGASVAVDLNTVTEATLGQDGQIILTGEDGHGYPVSVSGVITVPVSASMYQTMVANIQSDGTMQVVTPMVQVPKVESGNGDTTIEAVAIQGHPMTMINAAGEHQVLQVISLKDANVLTKAMQADVVKDEDSQQQQTVSSPE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00223616;
- 90% Identity
- iTF_01406244;
- 80% Identity
- -