Basic Information

Insect: Bombus opulentus
Gene Symbol: ewg
Assembly: GCA_034509555.1
Location: CM067412.1:3474711-3480049[-]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.2e-112 2.1e-108 361.1 0.1 1 212 60 270 60 271 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.2e-112	2.1e-108	361.1	0.1	1	212	60	270	60	271	0.98

Sequence Information

Coding Sequence: ATGGTGTCTCTGCCTAGTGCAGAGCCTGGCACAATGGATAGAATCTCAGATGATGACGAAGACGAACCAAGTAGTGGGTCTGAAACATATGAGGAGGGTGACCTTCTGACAGCTGCTATGGATGATGATGTAACGGCCCAGCTCGCCGCTGCAGGTTGGCAAATCAAACACGCTAATGGCCCTGTTGGCGTAGCAGCTGCCGCAGCCATTGTCTCagcgaaaaaaaggaaacgaccTCATAGCTTTGAAACAAATCCCAGCATTAGAAAGAGACAACAAAACAGACTCCTAAGAAAACTTAGACAAACCATAGATGAGTTTGCAACGCGAGTTGGACAACAGGCAGTAGTATTAGTAGCTACACCAGGAAAGCCAAACAGTAGTTATAAAGTATTTGGAGCAAAACCGTTAGAGGAtgtagtaaaaaatttaagaaatgttaTAATGGAAGAACTTGAAAGTGCGCTCGCACAACAAGCTCCGCCACCAGTACAAGACGATCCATCTTTATATGAATTACCACCTCTTATAATAGATGGCATACCAACACCCGTAGAAAAAATGACGCAAGCTCAACTCAGAGCATTCATCCCTTTAATGTTAAAGTATTCTACAGGCAGAGGTAAACCTGGTTGGGGAAGAGATAGTACACGGCCACCATGGTGGCCAAAAGAACTTCCTTGGGCAAATGTGCGTATGGATGCAAGGTCTGAAGACGAGAAACAGAAGatttcttGGACACATGCGTTAAGACAAATTGTAATAAactgttataaatttcatggaaGAGAAGATCTTCTACCTGCATTCAGCGAAGAAGATGATAAATCCAATGTACTGATACAACAATCGACTCCTCATTCCTCGTCGCATCCGTCACATTCATCCGGTCAAGGGCAAGGTGGACAATcgcagcaacaacagcagaCGGTGGGAGTTGTTCGCCTCAGCAGCACGGATTCATCTAAGGGAAACTCTTCGCCAGCACAAATCATTGCCACGTCTCCTACAGCTCTTGCCACTGCCACTCAGATGACGGCTCAATATCCGACGGCAGTTTTACAAACAATAACGAACCCTGATGGCACCGTATCGATCATCCAAGTTGATCCTAGTAACCCAATAATTACACTACCAGATGGTACAACAGCTCAGGTTCAAGGCGTAGCTACCATCCATACAAGTCAAGGAGAAGTACAAGCACTCGCTGAAGTAGCAGGCAATGGGGAAGGTACTAGTGTCGCTGTCGATTTAAACAGCGTTACAGAAGCAACATTAGGTCAAGATGGTCAAATCATTCTCACAGGAGAAGATGGACACGGCTATCCTGTTTCCGTCTCAGGAGTGATAACAGTACCAGTATCTGCTAGTATGTATCAAACTATGGTTGCCAATATTCAAAGTGACGGTACGATGCAAGTAGTCACACCAATGGTTCAAGTCCCAAAGGTTGAGCCTGGAAATGGGGAAACTAGCATTGAAGCTGTTACTATTCAAGGCCATCCTATGACAATGATAAACGCCGCAGGTGAACATCAAGTTCTTCAAGTAATATCATTAAAAGATGCTAATGTCCTCACGAAGGCTATGCAAGCCGAAGTTGTAAAAGATGAGGATAGTCAACAACAACAAACCGTCTCTAGTCCAGAATAA
Protein Sequence: MVSLPSAEPGTMDRISDDDEDEPSSGSETYEEGDLLTAAMDDDVTAQLAAAGWQIKHANGPVGVAAAAAIVSAKKRKRPHSFETNPSIRKRQQNRLLRKLRQTIDEFATRVGQQAVVLVATPGKPNSSYKVFGAKPLEDVVKNLRNVIMEELESALAQQAPPPVQDDPSLYELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRDSTRPPWWPKELPWANVRMDARSEDEKQKISWTHALRQIVINCYKFHGREDLLPAFSEEDDKSNVLIQQSTPHSSSHPSHSSGQGQGGQSQQQQQTVGVVRLSSTDSSKGNSSPAQIIATSPTALATATQMTAQYPTAVLQTITNPDGTVSIIQVDPSNPIITLPDGTTAQVQGVATIHTSQGEVQALAEVAGNGEGTSVAVDLNSVTEATLGQDGQIILTGEDGHGYPVSVSGVITVPVSASMYQTMVANIQSDGTMQVVTPMVQVPKVEPGNGETSIEAVTIQGHPMTMINAAGEHQVLQVISLKDANVLTKAMQAEVVKDEDSQQQQTVSSPE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00085025; iTF_00226337; iTF_00218851; iTF_00214151; iTF_00220999; iTF_00222279; iTF_00227018; iTF_00232362; iTF_00218158; iTF_00221678; iTF_00216815; iTF_00227697; iTF_00228401; iTF_00217493; iTF_00225653; iTF_00230453; iTF_00215447; iTF_00220215; iTF_00219544; iTF_00231739; iTF_00216130; iTF_00860865; iTF_00865066; iTF_00863019; iTF_00865750; iTF_00860126; iTF_00864382; iTF_01065985; iTF_01070088; iTF_01065294; iTF_01069390; iTF_01068026; iTF_01420676; iTF_01420035; iTF_01511940; iTF_00684554; iTF_00962930; iTF_00961567; iTF_00964223; iTF_00982027; iTF_01417447; iTF_00224300; iTF_00232974; iTF_00229771; iTF_01539344; iTF_00142225; iTF_00140326; iTF_01424114; iTF_00222932; iTF_00675765; iTF_01419389; iTF_00378466; iTF_01244962; iTF_00264009; iTF_00264752; iTF_00867134; iTF_00109569; iTF_00729804; iTF_00729032; iTF_01077209; iTF_00868509; iTF_01476674; iTF_00014471; iTF_01261617; iTF_00015796; iTF_00015136; iTF_01477320; iTF_00181069; iTF_00182386; iTF_00181718; iTF_00417303; iTF_01475930; iTF_00342883; iTF_00862307; iTF_01422659; iTF_01089732; iTF_01406244; iTF_00962246; iTF_01270249; iTF_01198401; iTF_01199139; iTF_00252548; iTF_00254052; iTF_00291270; iTF_00293450; iTF_01266637; iTF_01394862; iTF_01474414; iTF_01472911; iTF_01475184; iTF_01130546; iTF_01267282; iTF_00253299; iTF_01473652; iTF_01270935; iTF_00251800; iTF_00292024; iTF_00770107; iTF_00295741; iTF_00254815; iTF_01269536; iTF_00292675; iTF_00298041; iTF_00294202; iTF_00297279; iTF_01268739; iTF_01519971; iTF_01268007; iTF_01255275; iTF_00183698; iTF_00965793; iTF_00633366; iTF_00773527; iTF_00391032; iTF_01168917; iTF_00393336; iTF_01098938; iTF_01513211; iTF_01122174; iTF_01122826; iTF_00294976; iTF_00296506; iTF_00762986; iTF_01412042; iTF_01199875; iTF_01303043; iTF_01413891; iTF_01412836; iTF_00174757; iTF_00059914; iTF_01411212; iTF_00939252; iTF_01048629; iTF_01047988; iTF_00938399; iTF_01537578; iTF_00305995; iTF_01234763; iTF_01232165; iTF_01233381; iTF_00141576; iTF_00683911; iTF_01512584; iTF_00983375; iTF_00141011; iTF_00760730; iTF_01418112; iTF_01234093; iTF_00863699; iTF_01119968; iTF_01254540; iTF_01355052; iTF_01354364; iTF_01068717; iTF_01067351; iTF_01066688; iTF_00084270; iTF_00085905; iTF_00087669; iTF_00086841; iTF_00173902; iTF_00175500; iTF_00718261; iTF_00719114; iTF_01070799; iTF_01364367; iTF_00059184; iTF_00058418; iTF_00057660; iTF_00905155; iTF_00720988; iTF_01514575; iTF_00756368; iTF_00982704; iTF_00733730; iTF_01513904; iTF_00117746; iTF_00397010; iTF_00397795; iTF_00050548; iTF_00829219; iTF_00628843; iTF_00798315; iTF_00266191; iTF_01298895; iTF_01056528; iTF_01055707; iTF_01057372; iTF_01306128; iTF_01129077; iTF_01508602; iTF_00262400; iTF_00263098; iTF_00265408; iTF_00840788; iTF_01086964; iTF_00898505; iTF_00088522; iTF_00360650; iTF_00730476; iTF_00452333; iTF_00866447; iTF_01497935; iTF_00359956; iTF_00158839; iTF_00302777; iTF_00861626; iTF_00183036; iTF_00625246; iTF_01421300; iTF_00385020; iTF_01015550; iTF_00024384; iTF_00769376; iTF_01232756; iTF_00762293; iTF_00381590; iTF_00377742; iTF_00016440; iTF_01421976; iTF_00126440; iTF_00127185; iTF_00125650; iTF_00127923; iTF_00129466; iTF_00128703; iTF_01228755; iTF_01405427; iTF_01406966; iTF_01408793; iTF_00765277; iTF_01523111; iTF_00884791; iTF_01407902; iTF_00728412; iTF_00046694; iTF_00045873; iTF_00350739; iTF_01273529; iTF_00047707; iTF_00686940; iTF_01000996; iTF_01004806; iTF_01003278; iTF_01003961; iTF_00996775; iTF_00996073; iTF_01560177; iTF_00317205; iTF_00451671; iTF_01005752; iTF_00438489; iTF_00168124; iTF_00316509; iTF_01000285; iTF_01001824; iTF_00738076; iTF_00963612; iTF_00652416; iTF_00414034; iTF_01207085; iTF_01497120;
90% Identity: iTF_00879357;
80% Identity: -