Basic Information

Insect: Craniophora ligustri
Gene Symbol: MBD-R2
Assembly: GCA_905163465.1
Location: LR990957.1:4776394-4784726[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 9.1e-17 5.4e-13 49.1 0.0 5 59 774 832 770 891 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	9.1e-17	5.4e-13	49.1	0.0	5	59	774	832	770	891	0.79

Sequence Information

Coding Sequence: ATGGCCGTAAAAAAATGTTGTATTGACTACTGTAAGTCATGTTCAACAAGAAAGGAGGACAAGGGTGTAACATACCACAAGTTTCCCAAAAATGATAGATTACGTGACATTTGGATATCTGTAACACAAAACAAACACACAGACACAGAAATGCCCAAGTTTGTGTGCTCGCGGCATTTCTGTAAAACTGATTTTCAAATTTTCAAGGATGCTAAATACAAATTGAGATCAGACGCAGTACCATCAATATTCCCATGGGATACTGACACTGACGGAGAAATGGAAGACGCAACTATGTCAGTCGAGGGTTTTAGCAAAGATTGTGAAGTTGAGAATGTGGATGCTATCAAGAGATTTATTGAAGAACAAGAAAAAGAGCTGGAGGACCAGAGAATAGCAGATGTTCAGAATAGTGAGAAAACTACTCACACAGATACCAAGCCCAGTCAGGAAGAGACACTGTCCATGGCTAACAGTGTGATGGATATGATACTCAGTGAATCAGAAGTAGAGATAGCTGCTAAGCAAGAAGCAGATGTCAAAAATAAACCAATCTTTAGCCCTAGTGATAAAGAAAACAGCAGCATGGCATTATCTATTGGTTCCAAGGTTGAAGCTAAGGATTTCAGTGGACAGTGGCATTATGCAGAAATCAAAGAGGTTGACTATGAAGATATGGAGGTGCTTGTACATTATGAACATGACAAAAAAAAACACGACGAATGGATAAGTGTGAGCAGTCCGCGTCTTAGACCTGCGAGTGCCTCCACAGCTAGTACCTCCACTGCTAGTGCCTCCACTGCTAGTGCCTCCACTGCTAGTGCCTCCACTGCTAGTGCCTCCACTGCTACTGATACTGTTATCACGGTGAAACCAGGACCTAGTTCAGAGGAGAGTCTCACCGACACCATACCTATTGCCAACCTGAAAGAGGAACCTAAGGATATCAAGACTGAAGATAAAGCCAAGTTAAGCTTCACGGTTGGCGAGCGATGTCTCGCTAGGTGGCGCGACAATAGACGCTTTGTAGCCACGATACTTAATGTTTTGGAGAATGATAATTACGAGATATTGTTTGACGATGGTTGCCATTGGACGTGTAACGCGTCAAGGCTTTACAAACTGCGGTCGAAAAAGGGGGATGCCGACGCCAAGCCCGTTTCCCCACTACCTTACGGACCCGGGCCTAGTAACGCGGTCTCCGGTACAACCCAGCCCCCCATCTTCCACACACATCTCTTCGATCCCACCAGAGACTACCTAGGCTCAAAAAGTGAGCGCCGTGAAATGAAAAGAAAACTAAACATAAAAGAAATATTCAACATAGGGCAGAAACGGCCGAGGAAGCAAAATGCTCAAAAGGAAAAGAAAATGGTTGAAAGGAAACCTAGGGTTATGAAGAAGAAGCGAGAAAGAATTGTGAAACTTAAGCTGGAGAGTGAAGACACAATCGAGATTAAAACTGAAATGCCTGCTGTAGATGCAGTAGCCTCAATTATCGGCACAGTTACTCAAGAAGAACTAAATATACCAGCAGTTATAAAAGACGAGAAACCAGAGGCGCTGCCAGTTAACAAAGATGATAAAGAGGAAGAAATTAAGGTGGAAAAGAAAGAGGAAGGGATAAACCAAGTATCCGATGATGATATTCAATCTGATAAAATAACTGCTCCAGTTGAATCTATTGACAATGAGGATCTCATTCAATTAGCGGACCTCAAAGGAGATTTAGATCCGGTCCTAGAAGAGGAAGTAAAACTTGAGCAATTCGATAAGCCAGACGACATTAGACACGAGGAAGTAATTGACAGAATAAAAGAGGTCATCAACAAACTGGAAGATGGCCTCAATCAAGCTGATAAGGTTGGTTCTCCAAAACCAGAACCTAAAGAGGAAATACCTGCAACACCAGAACTCAAACCTCCACTGACGGAAGTTAAGGAAGAGGCTGATCTAACAAATGAATCAGCCAATAAACCAGTAAAAGCAGAAAAAGACAAATCAAAGAAACTCTCAAAGGTTAAGAAGGGTAAGAAATTGAGATTATTGCGCGAAAAGAAAGTGAAGAGGCAAGTGGAAAAGGTGAAGAGTGAGTTGGAGCTGGTGAGGAAGCAAGTGGACGAGATGAGGAAGCAGATGCTGAAGCGTCAGGAGTTAGCGAAGGTGGAGCCGGGCACTGTGCTATCTGAGAGCTTCTTGCTGCCTGGCGAGTGGTGCTGCCACTGGGTCAACGGCCAGCCCGTCGGCACCGTCAGCGAGATCGAGTGCGAGGTCAAGCAGGACTCTAGCGGGAAGCCGCCCCTGCCTAGGCGGAGTGTACAGGTTGCAGATAAAAGGTTACCAGAGGGTTGGACCAAACACATGGTTCGTAGAAGCTTCGGTCATTCTGCTGGGAAGTGGGATGTCGTGCTGGTCAGCCCCGAGAATCGAAGATTCCACACGAAGAACGAAATGCGCATTTACCTAGAAAACAATCCGGAGTTTGTTGAATATGAAAACGCGTTAACTGACTTTGGTGTTCACCTTAAGTTGGCTCGCCGCATGGGCTGGATCACCCACACTGCAGATGGCGCAGCCGGTCCCTCCTCGCCCCTCCCCTCCGGCACTCTGAGCAGCACCTCCCCCCTTGTCAAACGACGGAAACTGAGTCTCAAGAAGCCGACAGAGATAAAACATAAGAAGCCCAGACTGACGATTAAGATGAAGATACCGAAAACAGAAGCTGGTCTGCAAAGAAATGAAGCGGTACTGTCGCCAGAAATCCCCGGCATCGATCACAGCATGATTGATGAAACTAATCTAGATACCCCTCAGTTAGAAGACGGCTATGGTATGTACAACATGACATGTGATATAGGTAAAACGTTTATACAGAACATTCTTAGTAATCAAATTACTATGTCTGTGCGGTGTTAG
Protein Sequence: MAVKKCCIDYCKSCSTRKEDKGVTYHKFPKNDRLRDIWISVTQNKHTDTEMPKFVCSRHFCKTDFQIFKDAKYKLRSDAVPSIFPWDTDTDGEMEDATMSVEGFSKDCEVENVDAIKRFIEEQEKELEDQRIADVQNSEKTTHTDTKPSQEETLSMANSVMDMILSESEVEIAAKQEADVKNKPIFSPSDKENSSMALSIGSKVEAKDFSGQWHYAEIKEVDYEDMEVLVHYEHDKKKHDEWISVSSPRLRPASASTASTSTASASTASASTASASTASASTATDTVITVKPGPSSEESLTDTIPIANLKEEPKDIKTEDKAKLSFTVGERCLARWRDNRRFVATILNVLENDNYEILFDDGCHWTCNASRLYKLRSKKGDADAKPVSPLPYGPGPSNAVSGTTQPPIFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKRPRKQNAQKEKKMVERKPRVMKKKRERIVKLKLESEDTIEIKTEMPAVDAVASIIGTVTQEELNIPAVIKDEKPEALPVNKDDKEEEIKVEKKEEGINQVSDDDIQSDKITAPVESIDNEDLIQLADLKGDLDPVLEEEVKLEQFDKPDDIRHEEVIDRIKEVINKLEDGLNQADKVGSPKPEPKEEIPATPELKPPLTEVKEEADLTNESANKPVKAEKDKSKKLSKVKKGKKLRLLREKKVKRQVEKVKSELELVRKQVDEMRKQMLKRQELAKVEPGTVLSESFLLPGEWCCHWVNGQPVGTVSEIECEVKQDSSGKPPLPRRSVQVADKRLPEGWTKHMVRRSFGHSAGKWDVVLVSPENRRFHTKNEMRIYLENNPEFVEYENALTDFGVHLKLARRMGWITHTADGAAGPSSPLPSGTLSSTSPLVKRRKLSLKKPTEIKHKKPRLTIKMKIPKTEAGLQRNEAVLSPEIPGIDHSMIDETNLDTPQLEDGYGMYNMTCDIGKTFIQNILSNQITMSVRC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00383735;
90% Identity: iTF_00383735;
80% Identity: iTF_00383735;