Basic Information

Insect: Crambus lathoniellus
Gene Symbol: MBD-R2
Assembly: GCA_949710035.1
Location: OX453297.1:9094932-9114561[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.3e-15 1.5e-11 45.5 0.0 5 58 472 525 468 589 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.3e-15	1.5e-11	45.5	0.0	5	58	472	525	468	589	0.87

Sequence Information

Coding Sequence: ATGTCTTCAAAGCCAACGTCTCCAGCACCAAGCCAAGCACAAGTTACAAGTACTCCAAACCCTGGCAGTAATACCCTTCCTGTTGCTTCCAAGGATATCAAACAGGAACCGAAACTGAACTTTGAAGATAAGCCAAAATTAGTGTTTGCTGTCGGAGAGAGGTGCCTAGCTAGATGGAGAGACAACAGGAGGTTTACAGCTACTGTTAATAAAGATTTAGAAGATGgACATTATGAGGTAGTTTTTGATGATGGCTTTCTATGGAAATGTACAACCTCCAGATTGTACAAAATGAAAGATTCAAAGACAGATGGTTTAACCGTTGATACTACAGTGTCATCGCCTGGAACTCCTTTGGCATCGCCGGCTCAGTACGGCGCAGGACCAAGTAGCGTTTTACCCCTGCAGCCAGCCTTTCACACGCATTTGTTTGACCCCACCCGTGATTATCTAGGTTCTAAGAGTGAGCGTCGCGAAATGAAACGCAAATTGAACATCAAGGAGATCTTCAATATTGgacagaagaagaaaaagactgAAGCTAAAGATAAAGTGACAGGAGATACGCCTGTAGTGAAAAAGAAACCAAAGTTAATGAGGAAAAAACCAAAACCGCAACCGGCAGTAACCGTAAAGACTGAAATTCcagATGCAGTTGCATCTATAATTGGAACAGTCAAAGAGGAAGCATCTAATAAGGAAGTTAAAAAAGAACCAAGTGTAATAGAAGAATATGTCAAAGAAGAAATAACAACTCCTACAGGACTTATTCAAGATGAAGCAATAAAAACGGAAGAACTAGAAATTAAAGAAGATGAAAAAATAGAGTCATGTACAAATTCAAACACCAGTGAAAAAGAAGAAGATAGTTTGGATCCTGTTCAAAAGGAAGAAGTGAAACTCGAGAAATTCGATAAAATAGACGACACAAAGCACGAAGAAGTCATTGACAGGATCAAAGAGGTCATTAATAAGTTAGAGGATGGTATAAATAAAGTACAGAACTCCCCTAAACCAGAGGTTAAAGAGGAACCGCCTAAGGTCGAGCCCGAACCCGAGCCGATAAAACCAACAGTCGAAAAGGAACCTGTTAAAGATAAGAGTAAAAAGTTGGCAAAGGTAAAGAAAGGTAAAAAGTTGAGGTTGTTGCAGGAGAAGAAGGTAAAGAAACAGGTGGAGAAAGTGAAAAGCGAGTTGGAGGAGATGAAACGGCAGGTGGAGGAGATGAGGAAGCAGATGATGGCTAAAACCGAGGAGTTGTCGAAGGGGCACCAGGAGATGCCGGAAAGTTTCCTGCTGCCGGGCGAGTGGTGCTGCAGGTGGGTCAACGGGCAGCCGGTTGGGACAGTCAGCGAGCTTGATGCTGAAGTCAGGGATGCTAATGCCAAGCCTGGACTGCCTAGGAGAAGCGTTCAGGTTGAAGATAAAAGACTTCCACCTGGGTGGACTAAGCACATGGTTCGACGAAGTTTGGGCAATTCTGCAGGTAAATGGGATGTGGTCTTAGTAAGTCCGGACAACCGAAGATTCCACATGAAGTCAGATATGAAGAATTATATGGAAAATAATCCTAATCCAATTATTCAGCAATATGAGCATGTTCTTATGGATTTTGGTGTGCATTTGAAGTTAGCGCGTCGAATGGGTTGGGTCAAAACCACTCCAGGTGGCGTAGACGAAACTCCTGTAATATCTCTGCCGGCCGGTACTCTTTGCAGTACTTCCCCACTTGTGAaacgaaaaaaattaaatctaaaGAAAGTTCGCAAAGAGAAGGAAAAGAAACGGAAACTGGCGATTACTATCAGGATGCCTAAATATTTGGCGTCGAAAGCCAAACCAGCAAGTGCGACAGCACCCGACCAATCGTTAGCGGAAACCGAAAGTGCTATTCTAGATCCGCCGTTAGAAGATGGTTTTGTCTATGTGGGTTCATTGAAAGTACAAATACTTGAGAATCTTCTACGCTGTCCGGCCGAGGGATGTTTCAAGAACTTCAGGAATAACACTTTATTGAAAATGCATATCAAGCATTATCATAGAGAGCTAAAAAAAATGCTGGGAAAAACACCTAAAGTTTTAGACTTGGCTTACGCTAGAACCatgccgatttcaatgaaacagaCTAGGGTTAAAGGTCCtaaggttaaaaaaattaaaacgaaaATACAGAGGCGTCCAAAACGGGTTGTCGAGCCTAAAGTTGAGGTTAAGGAGCCTATTTCTGAGAAACTTGAGACGCAGGAAGTACAACCTATGTCAGTCGAAGCTGAAGAGACTGTTCCAAAATTACAAGACTCGCCTAAACTTCGACTTGCTCTGATTAACAAACCTGCTAAAAGACCTCGCGTGCTATTGCCCGTTCGTCGCCCCGAACCTGAGTTCGATCTAGCAGGTAACAACACCGATTCCAGCCAGGATATACCCATAGAATCAGTGGTAGACATTCCACTAATCGAAGCCTTGGATTTCGAAACAGCAATATCCACACATACTGTTACGAAGCCTCTCGATCTGTTCTCTAAGAAGAAAGACAGGAAGAAGATTGCTGTATTAACTCCAAAGCTGGTTAGTGAAGATGAGGATTGGTTCGGAGTGACTTCAGATGTGGAGACCCGCTCCAGTTTCCCAAGGTCTGGTACCCCAGATTCAAAGAATATGGACCAAAAATTAAACCCGGTATCTTCCGAGTCCAATGAAGAGCAGAAAGAGTCCAACTATATGTATACTGAGAACGGCGAACGCATAAAGATAGTCCACATGAAGCGAGAGGAGATCATAAATTGCCACTGCGGGTTCCGCGAGGAAGACGGGCTCATGGTGCAGTGCGAGCTGTGCCTATGCTGGCAACACGCACTCTGCCACAACATACAGAAGGAGAGCGAGgtgCCAGAGAAATACACGTGCAGCATTTGTCTGAACCCCCGTCGCGGTCGTCGTTCGCAGCGCTTCCTGCACGACCAGGACAGACTGTACGAAGGTCTCCTACCGGGGGCTCGGCCCAGCGAGCCGCTGCGGCGCTCTCATGAGCTGTCCGGAAACCTGCTGCGGATACAGGACGCCTTGCACGCACTGCGCGTCAAGTACTACGTGGCCACACTGTACGAGCCGCTGCGGCGCTCGCACGAGCTGTCCGGCAACCTGCTGCGGATACAGGACGCCTTGCACGCACTGCGCGTCAAGTACTACGTGGCCACACTGTACGAGCCGCTGCGGCGCTCGCACGAGCTGTCCGGCAACCTGCTGCGGATACAGGACGCCTTGCACGCACTGCGCGTCAAGTACTACGTGGCCACTAAAAAGGATCACCCGAAACTATACCTATGGGCGAAAGACTGGGAGAACGGCGAACTGAATATATCGCAGGAGCGACTAAACTCTGACTACTCAGACCTGAATGTGATGATCAGCGGCATCGGCAAGGAGAACCTGCCGCTCAAGCCCGAGGACTTGAAGGATCAGATGGAACTGCAGACACCGCCCTCTGAGGAACATGATAGGTACAGCCAGCGGGAAGTGGGGTTGGGCTCCCAAACCCTGCTGAGCAGTTTGCTGTCGAGCCCGGGCGGCGCCGCGCTCGACCTGCCGCTGCCGCTCAGCGCCGCCGAGCTGGAGCGGCTCGCCAAGACGGTGCAAGGTGAGCTTGGGGAGCGACGGGCGCGGGCCGACCGTCACTGTAGCTACAGTCACATAGGGATGGGCCCCAGACCCTGCCGCTGCCGCTCAGCGCCGCCGAGCTGGAGCGGCTCGCCAAGACGGTGCAAGACCCTGCCGCTGCCGCTCAGCGCCGCCGAGCTGGAGCGGCTCGCCAAGACGGTGCAAGAAGAGGTGCAACGCGTATCGGCGCCGCAGCCGGAGGCGGCCATAGAGAACAGCGCGTGCCGCGAGCGATTGTTGCGCCACATCCAGCGCTGCCAGGCCGTCATCGACGCGCGGCTCGACTCCATCGAGGCGCAGGTGGCGGAATTGGAGTCACAAGACCCTTCATTTGAGGACGACGAGACAGCCGACTACTTCCCGCGCACCAAACAGACTATCCAGATGCTCATGCGGGACCTCGACACTATGGAGGAACTGGGAGTTATCACATAA
Protein Sequence: MSSKPTSPAPSQAQVTSTPNPGSNTLPVASKDIKQEPKLNFEDKPKLVFAVGERCLARWRDNRRFTATVNKDLEDGHYEVVFDDGFLWKCTTSRLYKMKDSKTDGLTVDTTVSSPGTPLASPAQYGAGPSSVLPLQPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKKKTEAKDKVTGDTPVVKKKPKLMRKKPKPQPAVTVKTEIPDAVASIIGTVKEEASNKEVKKEPSVIEEYVKEEITTPTGLIQDEAIKTEELEIKEDEKIESCTNSNTSEKEEDSLDPVQKEEVKLEKFDKIDDTKHEEVIDRIKEVINKLEDGINKVQNSPKPEVKEEPPKVEPEPEPIKPTVEKEPVKDKSKKLAKVKKGKKLRLLQEKKVKKQVEKVKSELEEMKRQVEEMRKQMMAKTEELSKGHQEMPESFLLPGEWCCRWVNGQPVGTVSELDAEVRDANAKPGLPRRSVQVEDKRLPPGWTKHMVRRSLGNSAGKWDVVLVSPDNRRFHMKSDMKNYMENNPNPIIQQYEHVLMDFGVHLKLARRMGWVKTTPGGVDETPVISLPAGTLCSTSPLVKRKKLNLKKVRKEKEKKRKLAITIRMPKYLASKAKPASATAPDQSLAETESAILDPPLEDGFVYVGSLKVQILENLLRCPAEGCFKNFRNNTLLKMHIKHYHRELKKMLGKTPKVLDLAYARTMPISMKQTRVKGPKVKKIKTKIQRRPKRVVEPKVEVKEPISEKLETQEVQPMSVEAEETVPKLQDSPKLRLALINKPAKRPRVLLPVRRPEPEFDLAGNNTDSSQDIPIESVVDIPLIEALDFETAISTHTVTKPLDLFSKKKDRKKIAVLTPKLVSEDEDWFGVTSDVETRSSFPRSGTPDSKNMDQKLNPVSSESNEEQKESNYMYTENGERIKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQKESEVPEKYTCSICLNPRRGRRSQRFLHDQDRLYEGLLPGARPSEPLRRSHELSGNLLRIQDALHALRVKYYVATLYEPLRRSHELSGNLLRIQDALHALRVKYYVATLYEPLRRSHELSGNLLRIQDALHALRVKYYVATKKDHPKLYLWAKDWENGELNISQERLNSDYSDLNVMISGIGKENLPLKPEDLKDQMELQTPPSEEHDRYSQREVGLGSQTLLSSLLSSPGGAALDLPLPLSAAELERLAKTVQGELGERRARADRHCSYSHIGMGPRPCRCRSAPPSWSGSPRRCKTLPLPLSAAELERLAKTVQEEVQRVSAPQPEAAIENSACRERLLRHIQRCQAVIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTIQMLMRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -