Basic Information

Gene Symbol
Poxn
Assembly
None
Location
scaffold:67-5556[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2.3e-41 5.1e-38 130.1 0.9 1 74 14 87 14 92 0.97
2 3 6.2e-05 0.14 12.4 0.0 102 125 88 111 86 111 0.92
3 3 4.6 1e+04 -3.3 0.0 43 66 303 325 295 328 0.56

Sequence Information

Coding Sequence
ATGTACTTATACTTTACTGACTTACCCGGTGATTTTTCAGGTCAAGCAGGAGTCAACCAGCTGGGAGGTGTCTTTGTAAACGGACGTCCGCTTCCAGACTGCGTTCGACAAAGGATTGTCCAATTGGCACTGGTTGGCGTCCGTCCTTGCGATATCTCCAGACAATTGCTCGTTTCCCATGGCTGTGTTTCCAAGATATTAACCAGGTTCTACGAAACGGGGAGCATCAGGCCTGGCAGCATAGGTGGCAGCAAAACTAAGCAATTGGCAAGACAAGGAGCTTGCGATCCCCAAAGTTTGCCCTCGGTTTCTTCCGTCAATAGGATTCTTAGAGGCGGAGGATTGCACACGGATCATCCGATTGACGCTGGAGCCTCCGGAAGTTATCCAGGACATGTGTCAGGAAATGAATCCAGAGAATCCCTCATGAGAACGGATTATCAGCTGTTCTATCCCGGCTCACTGGGACCGCTCCACATATCCACCAACGGATCAACTGGAGCCTCCGGAGCATCCACCTGGAATCCTGGATTCTACTCCTCGCTTTATCAAGCGACGACATTGCACTTGCATCATGGAATGCAGTCCTTTACATCTTTAGAAACCGAGCGGCTTTCCGAGCAGCAGAACTCCCAGAACCAAGAACTAAAATCCAGCAGTTCAAGTTCCATGGCGGGAAGTGACGATTCTCTGGACAAAAGCGACCTGGACGAAGTTAATGAGTCCCAGGACTTCAAACCCTTTCAGAACTTGCCCACAATCTTAGAACTCGGGCAGAAAATCGGCAGCGACCGGAGTGCGTTTGTTCGACACGGAACTCCCGGTTCCGTTTCTAAAGAAAGTTCCGAGAACCCGCAACCAGCGCCACCACAGAGAAAGCGGAACCCTTATTCAATAGAGGAACTACTGAAGAAGGACGAAAATGTCGTCAGCAATAAGCGACGCGTTATTGACACTGGAGTTGTCCAACCTTGTGGAATTGTCGTTGACGAAAGGTTGTAA
Protein Sequence
MYLYFTDLPGDFSGQAGVNQLGGVFVNGRPLPDCVRQRIVQLALVGVRPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKQLARQGACDPQSLPSVSSVNRILRGGGLHTDHPIDAGASGSYPGHVSGNESRESLMRTDYQLFYPGSLGPLHISTNGSTGASGASTWNPGFYSSLYQATTLHLHHGMQSFTSLETERLSEQQNSQNQELKSSSSSSMAGSDDSLDKSDLDEVNESQDFKPFQNLPTILELGQKIGSDRSAFVRHGTPGSVSKESSENPQPAPPQRKRNPYSIEELLKKDENVVSNKRRVIDTGVVQPCGIVVDERL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2