Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0021 12 6.5 0.2 22 50 59 87 50 91 0.86

2 8 0.42 2.4e+03 -0.9 0.2 26 44 92 110 88 114 0.85

3 8 9.1e-05 0.53 10.8 0.3 21 51 115 145 111 147 0.86

4 8 0.016 91 3.7 0.2 21 51 143 173 139 174 0.83

5 8 0.0056 33 5.1 0.2 21 45 171 195 165 198 0.88

6 8 2.4e-07 0.0014 19.0 0.4 21 52 199 230 195 232 0.85

7 8 0.17 9.9e+02 0.3 0.1 23 41 229 247 226 254 0.70

8 8 8e-05 0.47 11.0 0.1 20 46 254 280 246 283 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0021	12	6.5	0.2	22	50	59	87	50	91	0.86
2	8	0.42	2.4e+03	-0.9	0.2	26	44	92	110	88	114	0.85
3	8	9.1e-05	0.53	10.8	0.3	21	51	115	145	111	147	0.86
4	8	0.016	91	3.7	0.2	21	51	143	173	139	174	0.83
5	8	0.0056	33	5.1	0.2	21	45	171	195	165	198	0.88
6	8	2.4e-07	0.0014	19.0	0.4	21	52	199	230	195	232	0.85
7	8	0.17	9.9e+02	0.3	0.1	23	41	229	247	226	254	0.70
8	8	8e-05	0.47	11.0	0.1	20	46	254	280	246	283	0.85

Coding Sequence: ATGGAGAAAAAAAATGAAATCAAAATTTTGGATAAAAATTCAGGAAGAAATATAAAAATTTACACTTGCGATGATTGTCAAGCGACTTTTGATAAAAAGTCAACTATGCAGACGCATATTAAGACTCATCAAGCAGACTTGTCTCAGAACAAAGCTCCAGAAATTGAGTCGGAGGACAAGCCATATTCTTGTGACGTCTGTCCTTCAAAGTTCCGTTTCGAAAGATATTTAAAACAGCACAAGCGAATAATCCACACGGAAAAAAAGCGTTTCTCTTGTGACAATTGTTCTTCAGCATTCCGAACAAGAACTCACTTGAACAGACACATGATTTGTCACTCGGGAGAACAACCTTACGCTTGCGACATCTGCAGGTCTCAGTTCCGGCGGAGGGGTAGTCTAAAAAAACACATGTTAATTCATAAAGAAGAAAAACCTTACCAGTGTAATATTTGTTCGTTGAAATTCCGGCACAGAGATTACTTGAACAGTCATGTTAGAATCCACTCGACGGAAAAACCTTTTGCTTGCAGCGTTTGTTCCTCCCAGTTCCGCCATAGAAGTACTTTGAACATGCACCTCAAGAGCCACGAGCAAGAGGAACCTTGTGTGTGTGCAATTTGCTCCGCTAAGTTCCGGAACAAGAAGAACCTGAGGGAACACATGAGGATTCACGTCGGAAACAAACCTCATAAATGTGTAATTTGTTCCGCGAGGTTCTTGAAGAAAAGTCTTTTGGAAAAACACACCCGGGTTCATACTAAGGAACGCCCGTTTTTATGTAACGTTTGTTCCTCGGATTTCCGGCAGAAAAGAGCTTTGGATCAACATATGAAAGTTCATTTTAATTAA
Protein Sequence: MEKKNEIKILDKNSGRNIKIYTCDDCQATFDKKSTMQTHIKTHQADLSQNKAPEIESEDKPYSCDVCPSKFRFERYLKQHKRIIHTEKKRFSCDNCSSAFRTRTHLNRHMICHSGEQPYACDICRSQFRRRGSLKKHMLIHKEEKPYQCNICSLKFRHRDYLNSHVRIHSTEKPFACSVCSSQFRHRSTLNMHLKSHEQEEPCVCAICSAKFRNKKNLREHMRIHVGNKPHKCVICSARFLKKSLLEKHTRVHTKERPFLCNVCSSDFRQKRALDQHMKVHFN

Sequence clustering based on sequence similarity using MMseqs2