Cfla002915.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cotesia flavipes
Gene Symbol
MBD-R2
Assembly
None
Location
scaffold:9099-19310[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.3e-15 2.7e-11 42.9 0.1 8 74 395 461 391 464 0.92
2 2 1.2 5.1e+03 -2.9 0.0 41 58 958 975 958 986 0.80

Sequence Information

Coding Sequence
ATGACAAAGTCACCCGCAAAAGGTGATAACAATTTACCAGAAAATTTAAGCCTGATCAACCTTGAAATGACACAATTGGAGCCAGAAAATCTACCTGAAGTTGAAGGGTCTAATTTAAAATCCGAAGATCTTAAAAAAGAAGTACCTAAAGATTTACTCGTAAATACAAGTAACAAATCTGAAAGTACAAAAAAACCAGCTGGTTCTGATAATTTGGGCACAAAAATTCAAAATGTGGTTGATACTACTGTTGAAAAAAAGGGATTCACTGAAGACCCACCCGCACAACCACCACCTCTTTTAGATGATCCAATGGACAATGTAAAACTTAATGATGATTCTTGTAAATCTAATGGCGACATAGAAAATAATATTCAAGAATCAAACGTTGAAAATGGAAAATTTTCCAAGTGTGTAGCTGTAGTTGTGGAGACTGATTGGAGAGAACGAGAAATTCTGATAAATTTTGATAAACGACGCCCGACGACTAACGAGTGGATATCGATGGACAGTCCTAGATTAAGAAGCATCCGACCCAGTGAGGAAGTATGGGTACAACCAACCGAGAGCTCCAAAATGCGTGAATTTATCGTCGGAGAAAGAGTTTTAGCAACGTGGGCAGATGGAAGAAAATATCCAGCTAAGATAAATGGAGTTTTGGAAGCAGATAAATATGACGTACTGTTTGACGATGGTTATCAAAAAATAGTCCGTGGATCGAAAATAACTAAAATAGCCTCTGCCAGTTCTAAGAATCCATCGAAGGGAATGGAGACAGATGCATACATTGGCAGCAAACAAGAGCGAAGAGATAAAAGCAGAAAGCACACAGTAAAAGATTTGTTTTCACACAAAAAAAGAGCTAAAGCGGAAGGAGTTGACCAATCACTGACCAAAAAAGATGACTTATCTTTGACTGATGCAGAGCAATTGCATAATTCTGAAAGCATGAACGAGAGTACTGATGCAGCTGGCGGACAGCTTGAAGAATCTATCTCGGAGCAAGTCCCGACCATCGAGACTCCAAAACCCAAGGCCAGGAATGGCACCAAGAGAAAGCGCGAAGTCGTGGTTGATTATGATGATGATAATGGACCAGAGTGGGTCGACGGTGAACCTCAGGGTGTTGAAGCATTTGTCGTAGATGGTAATGAAGGGACACGTCGATCTATATTAATTATTGATAAAAAATTGCCACCTGGATGGCAGAAACATTTCATCCAAAGAAAAACTGGCAACTCAGCTGGAAAATGGGACGCTGTATTTATTCACGAAGCTTCTAATAAAAAATTCAGGTCCAGAAGCGACTTGAGAGCTTTCTTCGAGACCCAGCGTCTCAGTAATTTTGATCCAAATAAATTTGACTTTTGTGTTCATCGCAGAAAAAGACCAGCTGTTCCTAAAGACAAATTAGATGCTAGTGCTGGTACTTCCTCGGCCACCAGTGAACCGGCTAAGAAAATAAAAACACTTTTGCCTAAAAGTAAAACTGCTGCGACAAATGATATGTTATTAACATCGGTAACTCCTAGTTATCTTACTCCAGTTCCTGCTACGCCTGTTGAAGATACTGGAGCAGTTTTTATTGGAGGACTAAGAGTTGAAATGGAGGACAGTGCGTATAAATGTCCGAAAGAAGGATGTGCCAAAACTTTTCGCAAAGAAAATCTCCTTCAAATGCACATAAAGCACTATCACCCCGAGTTTTCAAAATATCTTGGATCCACACCAAATGTCGCGGACTTGGCGTACGCGCGTACAATAGGCGAGCCAATTATCGACGGAACTCCCAAAAAATCAACCAGCAATTACGTCGACAAGCCAACAATTAGCCGAGGTGACAAAAGAAAGAGCCACTCTGATAAATTTTTAACACCTTTGGCCCACCAATCTTTTGCTACGTCTTCTCCGCTGTCCGTAGCGTCGCCTGATCTGTCTCAGATTGACCACCCGATGAATGGACTCAAAGATGACATAAAGTCCGACATGATGTCACCGTGCTCGAACGCTTCTCTGGATATTGACGATGAAATGGCCAAAAAATCAGACGGCAGCTGTGCTATGTCGCCCGGCACGCTGTTCGATTTAAAATCTAAGGAAGAAAAAACTCAAGCTGGGATTAAAACTTTGCTGCCTTTAAGGCCTGCTAATTCCGCGGATACTACTCGGCTGGATCGCTCCAAATCTCTTGATGACACGTTTAATGCTGACAGAGGACAACGCAAGCGTCAGTTGTCCGAGTACAGTTCTGATAATTCGACTAAAAGTAAAAAACGTCATGGCATACAGGAGCTTACGGATGATTATGGGGATTTAGATGACAGCGCAATGGATGTCGAAGGGCCTTCACCACTAGTGTATAGATTCAGTCGTAGAAAATCTGATTCTAAGAGCGACGATAACAGTCAGAATGGAGAATGTATGATGATGATGATAAATGGCGAGATGGTTAAAGTCGAACAATTAAAGCGCGAAGAGATAATAAATTGTACTTGCGGAGTCGTCGAAGAAGATGGACTGATGATACAATGTGATTTTTTAACTAACAGACATAAAAATCAAGACAGACTTAACAAACGATTTGCGATGTTGAAACGATCTAATGATTTAGTAGGAGCATTGCTGAAGGTTCAACAAGTTCTTTATAGTTTAAAAGTTAAAATCTGCGTTGCTCAAGTAAAAGACCATCCGAAATTATATCTCTGGGCCAAAAATTGGGAAACAACGGAGCTACCAAAGCCTCATCTTGAGCCTGTACCCATAATGGAAATAATAAAACCTGAGCCAACTACACCTGACATAGACGTCACTCAATCAGACATAAAACCCGAAGGAACATGTCCGATGACCAAAAGCGAGGTTAACGGCGACAAATCAATACACTCGGATTCAGAGTTGATGAAAATTCTTGAAGAGGACAACAGCTGTGTGGTTGATGAGCTGAAAGTCAAAAAAGAAACTTCGGATCCAAAAAGCAGCGAAGAAAGCCTGACAATAAAAAATGAGAACGAGGCGAGTCAGACAGATAAAACGGAAGATATTAAAATAGAAGATAGTGTTAAAGAAGATATTAAAGATCAACCTGGTGCGTCGAGTACGGATAATCAAGTACCATTTAATCCAAGTAATAATGATTCGCTGAATGATAGCAGGAGCAAGCAAGCAGCCAAGTCAAAGCCCTTTGAGTCATTACTAGAGCAACCACCGCTCCAGCCTCAGCAGCCTTTCATCCCTGAACCAGAAGCGCCGATTGATCCTGATGAATGTCGGCTACGTTTGTTGAATCACATAGAACACTTTCAGAACCATATGGAAGTACATCTGACCAGTGTTGAGAGCCAAGTTTCTTTTTTAGAAGCCATGGATCCTGATGATGACCTAGCTGCGGATAAAGTTGATATTCGGTGTAAAGAAACTATTCAAATGGTGATTCGTGATCTTGGTATTGTGAGAAAACTCGCAGCTTTATGCTGA
Protein Sequence
MTKSPAKGDNNLPENLSLINLEMTQLEPENLPEVEGSNLKSEDLKKEVPKDLLVNTSNKSESTKKPAGSDNLGTKIQNVVDTTVEKKGFTEDPPAQPPPLLDDPMDNVKLNDDSCKSNGDIENNIQESNVENGKFSKCVAVVVETDWREREILINFDKRRPTTNEWISMDSPRLRSIRPSEEVWVQPTESSKMREFIVGERVLATWADGRKYPAKINGVLEADKYDVLFDDGYQKIVRGSKITKIASASSKNPSKGMETDAYIGSKQERRDKSRKHTVKDLFSHKKRAKAEGVDQSLTKKDDLSLTDAEQLHNSESMNESTDAAGGQLEESISEQVPTIETPKPKARNGTKRKREVVVDYDDDNGPEWVDGEPQGVEAFVVDGNEGTRRSILIIDKKLPPGWQKHFIQRKTGNSAGKWDAVFIHEASNKKFRSRSDLRAFFETQRLSNFDPNKFDFCVHRRKRPAVPKDKLDASAGTSSATSEPAKKIKTLLPKSKTAATNDMLLTSVTPSYLTPVPATPVEDTGAVFIGGLRVEMEDSAYKCPKEGCAKTFRKENLLQMHIKHYHPEFSKYLGSTPNVADLAYARTIGEPIIDGTPKKSTSNYVDKPTISRGDKRKSHSDKFLTPLAHQSFATSSPLSVASPDLSQIDHPMNGLKDDIKSDMMSPCSNASLDIDDEMAKKSDGSCAMSPGTLFDLKSKEEKTQAGIKTLLPLRPANSADTTRLDRSKSLDDTFNADRGQRKRQLSEYSSDNSTKSKKRHGIQELTDDYGDLDDSAMDVEGPSPLVYRFSRRKSDSKSDDNSQNGECMMMMINGEMVKVEQLKREEIINCTCGVVEEDGLMIQCDFLTNRHKNQDRLNKRFAMLKRSNDLVGALLKVQQVLYSLKVKICVAQVKDHPKLYLWAKNWETTELPKPHLEPVPIMEIIKPEPTTPDIDVTQSDIKPEGTCPMTKSEVNGDKSIHSDSELMKILEEDNSCVVDELKVKKETSDPKSSEESLTIKNENEASQTDKTEDIKIEDSVKEDIKDQPGASSTDNQVPFNPSNNDSLNDSRSKQAAKSKPFESLLEQPPLQPQQPFIPEPEAPIDPDECRLRLLNHIEHFQNHMEVHLTSVESQVSFLEAMDPDDDLAADKVDIRCKETIQMVIRDLGIVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00378812; iTF_00378757;
90% Identity
-
80% Identity
-