Ctra018038.1
Basic Information
- Insect
- Cosmia trapezina
- Gene Symbol
- -
- Assembly
- GCA_905163495.1
- Location
- LR991028.1:23062254-23065265[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 7 0.0047 9.5 7.7 0.1 26 62 44 80 32 87 0.84 2 7 0.0047 9.6 7.7 0.1 26 62 91 127 80 134 0.84 3 7 0.0045 9.2 7.7 0.1 26 62 138 174 127 183 0.84 4 7 0.0047 9.5 7.7 0.1 26 62 185 221 174 228 0.84 5 7 0.0052 11 7.5 0.1 26 62 232 268 223 274 0.83 6 7 0.0069 14 7.1 0.1 26 60 279 313 268 322 0.83 7 7 0.033 68 4.9 0.1 26 63 326 363 316 401 0.81
Sequence Information
- Coding Sequence
- ATGTATAGGAGTGTTGTGTTTTCGCGAAAGCAGAGCACGGCTGACCGACAGCCTAGTGAAGTGAATATAACTATGCGTCACCTTGAGGAACATGCCGCGCTCGAGCTCGGAGAAGTCCCGCTGCAGCACGTCCCACAGCCAGCACACCACGCGGTGCGAGTCGTGGAACCCGCCGTAGTACTGAGTATATCACATTACTGTGTGTCACATGTAGTGCGTCACCTTGAGGAACATGCCGCACTCGAGCTCGGAGAAGTCCCGCTGCAGCACGTCCCACAGCCAGCACACCACGCGGTGCGAGTCGTGGAACCCGCCGTAGTTCTGAGTATATCACATTACTGTGTGTCACATGTAGTGCGTCACCTTGAGGAACATGCCGCGCTCGAGCTCGGAGAAGTCCCGCTGCAGCACGTCCCACAGCCAGCACACCACGCGGTGCGAGTCGTGGAACCCGCCGTAGTACTGAGTATATCACATTACTGTGTGTCACATGTAGTGCGTCACCTTGAGGAACATGCCGCACTCGAGCTCGGAGAAGTCCCGCTGCAGCACGTCCCACAGCCAGCACACCACGCGGTGCGAGTCGTGGAACCCGCCGTAGTACTGAGTATATCACATTACTGTGTATCACATGTAGTGCGTCACCTTGAGGAACATGCCGCGCTCGAGCTCGGAGAAGTCCCGCTGCAGCACGTCCCACAGCCAGCACACCACGCGGTGCGAGTCGTGGAACCCGCCGTAGTACTGAGTATATCACATTACTGTGTGTCACATGTAGTGCGTCACCTTGAGGAACATGCCGCACTCGAGCTCGGAGAAGTCCCGCTGCAGCACGTCCCACAGCCAGCACACCACGCGGTGCGAGTCGTGGAACCCGCCGTAGTACTGAGTATATCACATTACTGTGTATCACATGTAGTGCGTCACCTTGAGGAACATGTCGCGCTCGAGCTCGGAGAAGTCCCGCTGCAGCACGTCCCACAGCCAGCACACCACGCGGTGCGAGTCGTGGAACCCGCCGTAGTACTGAGTATGTCACATTACTGTGTGTCACATAGAGTGCGTCATCTTGAGGAACATGCCGCGCTCGAGCTCGGAGAAGTCCCACTGCAGCACGTCCCACAGCCAGCACACCACGCGGTGCGAGTCGTGGAACCCGCCGTAGTACAGAAGTGCGTCACCTTGAGGAACATGCCGCGCTCGAGCTCGGAGAAGTCCCGCTGCAGCACGTCCCACAGCCAGTACAACACGCGGTGCGAGTCGTGGAACCCGCCGTAG
- Protein Sequence
- MYRSVVFSRKQSTADRQPSEVNITMRHLEEHAALELGEVPLQHVPQPAHHAVRVVEPAVVLSISHYCVSHVVRHLEEHAALELGEVPLQHVPQPAHHAVRVVEPAVVLSISHYCVSHVVRHLEEHAALELGEVPLQHVPQPAHHAVRVVEPAVVLSISHYCVSHVVRHLEEHAALELGEVPLQHVPQPAHHAVRVVEPAVVLSISHYCVSHVVRHLEEHAALELGEVPLQHVPQPAHHAVRVVEPAVVLSISHYCVSHVVRHLEEHAALELGEVPLQHVPQPAHHAVRVVEPAVVLSISHYCVSHVVRHLEEHVALELGEVPLQHVPQPAHHAVRVVEPAVVLSMSHYCVSHRVRHLEEHAALELGEVPLQHVPQPAHHAVRVVEPAVVQKCVTLRNMPRSSSEKSRCSTSHSQYNTRCESWNPP*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -