Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0059 1.6e+02 4.1 0.1 25 43 108 126 93 130 0.80

2 6 0.0012 32 6.2 0.1 21 52 132 163 127 165 0.87

3 6 0.00025 6.6 8.5 0.2 21 46 160 185 157 191 0.89

4 6 0.0018 48 5.7 0.1 21 51 188 218 185 219 0.87

5 6 0.00089 24 6.7 0.2 21 52 216 247 212 249 0.84

6 6 0.00053 14 7.4 0.1 22 43 245 266 240 274 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0059	1.6e+02	4.1	0.1	25	43	108	126	93	130	0.80
2	6	0.0012	32	6.2	0.1	21	52	132	163	127	165	0.87
3	6	0.00025	6.6	8.5	0.2	21	46	160	185	157	191	0.89
4	6	0.0018	48	5.7	0.1	21	51	188	218	185	219	0.87
5	6	0.00089	24	6.7	0.2	21	52	216	247	212	249	0.84
6	6	0.00053	14	7.4	0.1	22	43	245	266	240	274	0.89

Coding Sequence: ATGGAAACGCGCGCTTTAATGTATCCGAATAGTATTCAACAAGAATATAGTAATTCTTTACGGAATGATTCGgtatttcgttttattcttgAACATCAAGTAGAAGCTTGCAATCAAATTTCCGATAATATATTTTCGACTAAACATCATCAACGTACGTTTAACGAATCCGATGAAAATTCTGAAGAGAAATCAGAAGAAGTGGTTATTGACGTTGATGTTTGTATCGGTCAATCGAACGTTAGCAATTCTGATGATACTAATTCCGATAGTTATTCGGTCACCGATAAACCGATAGATTGTAAATTGCGAGCGTCCAATCATCGATGTAGAGTCTGTTTCAAAACTTTTTCTCAgagcGTAAATTTATTCACGCACGAACGCATACATTCGGGCGAACGACCATTTCGTTGTGAATTCTGTTTAAAAACGTTCACGCAGCAACCGAATCTTGTGAAACACGTGCGAATACACACCGGAGAGAAACCGTACGTTTGTCAGATATGTGAGAAAAGTTTCACGCAACAGGCAAATCTGACTAAACACATTCGAATACATACCGGCGAAAGACCTTACCTTTGTAAAGTATGTGGTAAGTCGTTTACGCAACAGGCTAATTTAACCAAACACAATCGATTGCATACCGGCGAAAAACCGTACAGTTGTCGGTTCTGCGATAAAAATTTCGCTCAGCAGGCGAATTTAGAACGACACGAAAGAGTACATACCGGTAAAAAACCGTAcgtttgtaaaatatgttggaAAACGTTTTCGCAGCGTAACAATCTTACGAAGCATCAGGTAACACATAACACCGTCAAAGAAGAACGTTGCGTTGtacgtaataataacaacaataataataataaacgctcTAAATCAGATAAGAAATCGCGTGCTACTCATTCTTTTTATtcttaa
Protein Sequence: METRALMYPNSIQQEYSNSLRNDSVFRFILEHQVEACNQISDNIFSTKHHQRTFNESDENSEEKSEEVVIDVDVCIGQSNVSNSDDTNSDSYSVTDKPIDCKLRASNHRCRVCFKTFSQSVNLFTHERIHSGERPFRCEFCLKTFTQQPNLVKHVRIHTGEKPYVCQICEKSFTQQANLTKHIRIHTGERPYLCKVCGKSFTQQANLTKHNRLHTGEKPYSCRFCDKNFAQQANLERHERVHTGKKPYVCKICWKTFSQRNNLTKHQVTHNTVKEERCVVRNNNNNNNNKRSKSDKKSRATHSFYS

Sequence clustering based on sequence similarity using MMseqs2