Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_963682025.1
Location
OY821517.1:306566991-306575757[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.4e-23 4.4e-19 70.6 0.1 3 76 418 489 416 490 0.93
2 2 0.95 1.7e+04 -1.8 0.0 43 63 920 938 914 950 0.82

Sequence Information

Coding Sequence
atgggTCGTCGGTGTTGTATAGCCGGCTGTTCATCTACTTCACGCCTACCCGAACATCATGGTGTAACTTATCATTCATTTCCTGTAGATGAAAATACGCGATCTATTTGGATACGTAACACAAAATTAAGTGCTGATCGCCATATTACTAAAAGTGTTTTAGTATGTTCTCGTCACTTTCGACGTGCCGACTTTCAGCCACAACGTAGTGGAAAATATCTATTAAAGCAAAAAGTCTTTCCAACAGTATTTCCTTGGGGTAAAATTGAGGCAAAACAGATAGAGGAAGATTTGGAGTTTTTAAATACATCCGGAATAGCACCAGGACCCAGTGCCGTATTGACCTCGTCATCTGTGGTTGATGATGATACCAAAGCTACGGTTGCCGCAACTGTGGCACAAATAATGGCTCAGACAGCGGAATTAAATGCGGCAGCTGGTATAAAATTAGAAAACCCCGATGGAGATGAAGGGCTAGCAGAAGGTTTAGCAACTACAAGTCCAAATTCTCCTCCAGGTGTTAAATTTGAACCCGTTAGTTCTTTCAATCCAGGAGCACGTCTCGAAGCTCAGGATTTCGATGGTATTTGGCATTCAGCTCGTATAGTCGAAGTGGACAATGACGATCGtgaagttttaattaaatttgaaaaatccgGGAAAAATAAATCCACCATGGCTGGTACTGAAGAATGGATTCCCATGAATTCATCGCGTCTCCGACAAAGACAATCCACCAAGCCTATTTTGAACTTTAATTTAGAAGAGAAATGTTTAGCCAGATGGTCAGGGCCACGTAAATTTCCTGGTACGGTGAAAAAAGTTCTAGCCAACGATACGTATGAGATTTTATTCGATGAtggttatataaaaaatgttcgcGCTATACACATGAACAAAGTACAATCTGCAGTTGTAGAACCTCAAGTACTTGAAAATATACCTGAGGAGATTCCTGTGGAAACACCAACTAAAATACCAACACCATTGTCTACACCGGTGGCTGTTACAACATCTACACCTACAACTATTAAACGGCCTTCTTCTGGTCAAAGTTCAGGTTCACAACCTAAAAGACGTGCTCCCAATGGACCACGTAAAGATTGGCCCCTTTTGGATTTATCGAAACTGGATTTGTCTTCTTTAAATCTTCCTGAAATCCCAAAAGATGGCGAATGGACTTGTCATTGGGTCAACGATCAACCTATAGGTCGTGAGGGATATCTGGTGGTGGGAGAACATCGTAAACCTACCGTTGTCGTAGATGATTGGCGTTTACCAGCGGGTTGGATCAAACATATGTATCAACGTTCAAATGTTTTAGGAAAATGGGATGTTATTCTAGTTACACCCAATGGCAAACGTTTTAGATCAAAGGCTGACCTCAAGACCTATTTAGAAGAAAAGGGCCAGGTGTATAATCCAGATATATACGATTTTAGTATACATCGTCGCCGAGCTAAAGATATCAATTGTTATGCTCACACTCCTGATTATGTACCACAACAACCATTCAAATCAAAAACTGCTTTGAATACTTCATTGGACACAAGTTTTGAAGCGAAATCGGAAGCTGTAGGAACTTTAGCAACGAGCGTGCCCTCACCTTATATGGAAACCCCTATAGCGGAACCGTTGCCACCCATAGAACTGTTAACGACATCAACAACAAGTTTGTCAGCTGAAGACAAAAGTGTTACTCAAGTTGAAGCTGATTTGCCTAAACAACTTTTAGAATCGGCTGAGGTCAGTTCTACGCCTACTCCTACATCGACACCTACTGTGGGCTTAAAGGAGGAAGTTGCTGCTGCTCCAGAATGCGCTACACCACCTGTAACGGTGGTGGAAACAAAAGTCGATGATGGatttgCTCTTATTGGTGGTCTAAAGGTTCAAATCATTGACAATTTATTCCGTTGTCCCCAAGAGGGTTGTTCCAAGAATTTCCGCAAAGAAAACCATTTACAAATTCATGTCAAACATTATCATCGCAATCTTGTTAAATTACTGGGTGCTTGCCCTAAAATGCAAGAGTTAGCTGAAAAACGTACACATTCTGTGGAGCATGACCCCAATGAGCCAGTACCGAAAAACCAAATATCCAATCAGCAATTCTTTGCTAAACTACATCAACAAGATTTAGAACATACTCGGGCACATCGCAGAAGTGTAGGTGTTAGCAAACCACCCACCACCACCACAGAGCCATCTTTAGAGATAAAACCTGAGTTGACAGAGGAGAAAATTAAAGAGGAGGACGAACAGATTGCTGAAAGTTCCCTAAATGATACATCTTTAATTAATACTACCACAGCATCTAGTTCTGTTGTTGATAATTCAGTTACTACAAACACAACAGCTGATAATTCAGCCTTAACAGAAACTGCTTTGGATGATGTGCCATTAATTAAGAGATCAAAAATTTCACCTACCAAAAGGTCTGGAGCCTCGAGGAAAAGCAATCGTCAAAGAACTACTAGAAAATATCTCACAGCAGCTCAAGCTACGGCCGGTGTAGTGACTACGGTCAATGCTTCTACACCTTTACCGCTCACCGGCTTAGCAGATACAAGTTTCAGCGGTGTAGCTGAATTTGAAGAGACACGTCATTCGTTCAACGCTACTCCCGATATAAATAAAGATGTCAAGAAACGTAAATCTGGTGTCCTGCCATCCAATACACCTCTTAGCAGTGCCGATTCACCAATTACAGCCGATTCTGGTTCGAATTCCTTCCAACCAACTAACTCTACCGAGGCTGATACTATCAACCAGCCTCCTCAATACATCAAAGAAAATGGTGAACTTATTAAAATAGTCCATATGCGACAGGAGGAAATCATCAATTGCCTTTGTGGTTATTGTGAAGAAGATGGTTTAATGATACAATGTGAGCTATGTCTTTGCTGGCAACATGGCATATGCAATGGCATCGATAAAGTCTCACAAGTTCCCGATAAATATGTTTGCTATATATGTCGTAATCCTCAGAGAAGTCGTGAATCTATACGTTATAAACATGATCAAGATTGGTTATTTGAAGGCAAACTACCAGTGGCTAATTTCCATCTCACCAACAATGCACAATATACAAAACGATCAGAATATCTGAAACGTTCACATACATTGACGGGTAATCTATTGGAACTGAAGAACTATATGCACTCCTTGAAGGTTAAAATTAATATAGCCAACAATAAATGTCATCCCAAGCTGTATCTATGGGCTAAGAAATGGGATGAGGATATGGAGGGAGTGAAAAGTGAAATTAAGACAGAATTGGAAATGAACTCTAAAACTAATAATACGAATTTGATACTTACGCCCTctgcaaagaaaataaaattagaacCTAATACTCCACCACAATTGGTGCCAAATATACCACAGCCAGAAGCTCCCATCGATGCATTGGAATGCCAGCAACGTCTGTTGGAACATATTAAAATACAGCAAAAATTGGTAATGGGTCGCTTAAATGACATTGAAGCCGCCATAGATGTTTTGGAACGTGAAGATGAAATGCCCGATTTACGTGAAGCTGATTTGGGTGCTACTAAAGATGTTTTGGCTGCCTTTATTAAAGAATTGGAAACTGTCAAACATATTGCCAAGTTGAATACTTTGGAACATACCATGTTGGCTTATAAGAATCCTATTCACCCCATCAATTGA
Protein Sequence
MGRRCCIAGCSSTSRLPEHHGVTYHSFPVDENTRSIWIRNTKLSADRHITKSVLVCSRHFRRADFQPQRSGKYLLKQKVFPTVFPWGKIEAKQIEEDLEFLNTSGIAPGPSAVLTSSSVVDDDTKATVAATVAQIMAQTAELNAAAGIKLENPDGDEGLAEGLATTSPNSPPGVKFEPVSSFNPGARLEAQDFDGIWHSARIVEVDNDDREVLIKFEKSGKNKSTMAGTEEWIPMNSSRLRQRQSTKPILNFNLEEKCLARWSGPRKFPGTVKKVLANDTYEILFDDGYIKNVRAIHMNKVQSAVVEPQVLENIPEEIPVETPTKIPTPLSTPVAVTTSTPTTIKRPSSGQSSGSQPKRRAPNGPRKDWPLLDLSKLDLSSLNLPEIPKDGEWTCHWVNDQPIGREGYLVVGEHRKPTVVVDDWRLPAGWIKHMYQRSNVLGKWDVILVTPNGKRFRSKADLKTYLEEKGQVYNPDIYDFSIHRRRAKDINCYAHTPDYVPQQPFKSKTALNTSLDTSFEAKSEAVGTLATSVPSPYMETPIAEPLPPIELLTTSTTSLSAEDKSVTQVEADLPKQLLESAEVSSTPTPTSTPTVGLKEEVAAAPECATPPVTVVETKVDDGFALIGGLKVQIIDNLFRCPQEGCSKNFRKENHLQIHVKHYHRNLVKLLGACPKMQELAEKRTHSVEHDPNEPVPKNQISNQQFFAKLHQQDLEHTRAHRRSVGVSKPPTTTTEPSLEIKPELTEEKIKEEDEQIAESSLNDTSLINTTTASSSVVDNSVTTNTTADNSALTETALDDVPLIKRSKISPTKRSGASRKSNRQRTTRKYLTAAQATAGVVTTVNASTPLPLTGLADTSFSGVAEFEETRHSFNATPDINKDVKKRKSGVLPSNTPLSSADSPITADSGSNSFQPTNSTEADTINQPPQYIKENGELIKIVHMRQEEIINCLCGYCEEDGLMIQCELCLCWQHGICNGIDKVSQVPDKYVCYICRNPQRSRESIRYKHDQDWLFEGKLPVANFHLTNNAQYTKRSEYLKRSHTLTGNLLELKNYMHSLKVKINIANNKCHPKLYLWAKKWDEDMEGVKSEIKTELEMNSKTNNTNLILTPSAKKIKLEPNTPPQLVPNIPQPEAPIDALECQQRLLEHIKIQQKLVMGRLNDIEAAIDVLEREDEMPDLREADLGATKDVLAAFIKELETVKHIAKLNTLEHTMLAYKNPIHPIN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01165527;
90% Identity
iTF_00371099;
80% Identity
iTF_00371099;