Basic Information

Gene Symbol
LITAF_1
Assembly
GCA_031163375.1
Location
CM062078.1:10486973-10489568[-]

Transcription Factor Domain

TF Family
zf-LITAF-like
Domain
zf-LITAF-like domain
PFAM
PF10601
TF Group
Zinc-Coordinating Group
Description
Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.2 9.1e+03 -2.5 0.1 15 25 40 50 37 52 0.80
2 2 4.7e-24 1.9e-20 73.4 17.1 2 69 60 128 59 129 0.92

Sequence Information

Coding Sequence
ATGGGCTTGCCCCCACCTTACGAGCAAGCGATGCCCAATCCTGCGCCACCGCCATCTTACTTCGGGAACAACCCTCCGCCGCCGCCGGGTCTCGTCGTGCCCCCGGCGACAGCGCCCCGCACCACCGTCATCACCACACAGCCTGGGTCCGGCTTGGCCCCAGGAAAACTGGGCCCTGGCCCCACGGGGACAACATGCGCCACGTGCTCTAAATCAATTGTCACACGAGTCGACTATGTGCCCAACAATCGGACGCACATCATCTCTGCAGCTCTCTGCGTTCTAGCGAGTTGCTGTTGCGGCTGCTTCGTCCCCTACTGCATGAGGTCCTGCAAAACTGCCAACCACTACTGCCCGCAATGTCAAGCGTTCGTCGGGTCATATATCCCTTCTTGA
Protein Sequence
MGLPPPYEQAMPNPAPPPSYFGNNPPPPPGLVVPPATAPRTTVITTQPGSGLAPGKLGPGPTGTTCATCSKSIVTRVDYVPNNRTHIISAALCVLASCCCGCFVPYCMRSCKTANHYCPQCQAFVGSYIPS*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01543523;
90% Identity
iTF_00408958;
80% Identity
-