Cpun013976.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Conogethes punctiferalis
Gene Symbol
Ipmk
Assembly
GCA_031163375.1
Location
CM062090.1:15628966-15638857[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 24 0.11 2.8e+02 2.0 0.0 22 54 291 323 286 337 0.89
2 24 0.11 3e+02 2.0 0.0 22 54 340 372 334 382 0.89
3 24 0.11 2.8e+02 2.1 0.0 22 54 389 421 383 434 0.89
4 24 0.11 2.9e+02 2.0 0.0 22 54 438 470 432 481 0.89
5 24 0.12 3e+02 1.9 0.0 22 54 487 519 482 529 0.89
6 24 0.11 2.9e+02 2.0 0.0 22 54 536 568 531 581 0.89
7 24 0.12 3e+02 2.0 0.0 22 54 585 617 578 626 0.89
8 24 0.11 2.9e+02 2.0 0.0 22 54 634 666 628 678 0.89
9 24 0.11 2.8e+02 2.0 0.0 22 54 683 715 677 727 0.89
10 24 0.12 3.1e+02 1.9 0.0 22 54 732 764 726 772 0.89
11 24 0.11 2.9e+02 2.0 0.0 22 54 781 813 775 825 0.89
12 24 0.11 2.9e+02 2.0 0.0 22 54 830 862 822 871 0.89
13 24 0.11 2.8e+02 2.1 0.0 22 54 879 911 872 923 0.89
14 24 0.11 2.9e+02 2.0 0.0 22 54 928 960 923 973 0.89
15 24 0.12 3.2e+02 1.9 0.0 22 54 977 1009 971 1016 0.89
16 24 0.11 2.9e+02 2.0 0.0 22 54 1026 1058 1020 1071 0.89
17 24 0.11 2.7e+02 2.1 0.0 22 54 1075 1107 1069 1122 0.89
18 24 0.11 2.9e+02 2.0 0.0 22 54 1124 1156 1116 1165 0.89
19 24 0.11 2.8e+02 2.0 0.0 22 54 1173 1205 1167 1217 0.89
20 24 0.11 2.9e+02 2.0 0.0 22 54 1222 1254 1216 1267 0.89
21 24 0.11 2.8e+02 2.0 0.0 22 54 1271 1303 1265 1315 0.89
22 24 0.11 2.9e+02 2.0 0.0 22 54 1320 1352 1313 1363 0.89
23 24 0.11 2.8e+02 2.1 0.0 22 54 1369 1401 1361 1413 0.89
24 24 0.12 3e+02 1.9 0.0 22 54 1418 1450 1413 1460 0.89

Sequence Information

Coding Sequence
ATGTCCCATGAGGGCTCGAAGGCGCGGAGGGCCGTGCGCGTGCAGCGCTCCATCCCGCTCGTGCACTACGACCTGCCGCGGCGCTGCGCCGAGGACGTGGCGAAGCCCCTGCTGATGTCGCCCGGGGAGCTGCAGGCCTTCGGGCTGCAGGTGGCCGGCCACAGGGCCAGCGACGACAAGAAGTTCACAGGTCTGCTCCAATGCAACGGCACGGTCCTGAAGCCGATCCTGAAGGAGTCGCAGAAGCGCGAGGTGGACTTCTACGAGCGTCTGCAGCGCGCCGGCGAGCGCGACCTGCGGGAACTGCGCGCCTTCGTGCCCAAGTACTACGGCTGCAAGAAGTTCAGCTACAAGGGCTTCGAGCAGGACTACATCATCATGGAGGACCTCACGCAGCGGATGCTGGAGCAGTGCGTCATGGACGTCAAGATTGGCAAAAGAACATGGGACCCGCTGGCCACAGAGGAAAAGATGAAGCGCGAGCAGAGCAAGTACGCTCTGTGTAAGCAGCAGTACGGGTTCTGCATCCCGGGCTACCAGGTGTACAAGCTGGCCACGGGCAAGTTCCTCAAGCACGGCAAGGACTACGGGAAGAAGCTGCACGGGCGCATGGTGAGAGAGGCGATACGCAACTACCTGAACGGCGTGGGCGGCCGCCTGTGCCGAGCGCTCGTGCTGCAGTTCCTGTCCGAGCTGTGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGTGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGTGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGTGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGTGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTGTACGACGCCGCGAGACTGCGCGACTGCTGCGGCGACCTCGAGCTGCCGTGAGTACCCTCCTGCCGCTGCTGTCAGCTGCGGCAGATACAGAAGTGGGCCAGGCGACAGCGCAGCGTGCGGCTGTACTGCGCCTCGCTGCTGCTGGTgtcaccaggcctccTCCCCGCAACATCTGA
Protein Sequence
MSHEGSKARRAVRVQRSIPLVHYDLPRRCAEDVAKPLLMSPGELQAFGLQVAGHRASDDKKFTGLLQCNGTVLKPILKESQKREVDFYERLQRAGERDLRELRAFVPKYYGCKKFSYKGFEQDYIIMEDLTQRMLEQCVMDVKIGKRTWDPLATEEKMKREQSKYALCKQQYGFCIPGYQVYKLATGKFLKHGKDYGKKLHGRMVREAIRNYLNGVGGRLCRALVLQFLSELWQIQKWARRQRSVRLYCASLLLVYDAARLRDCCGDLELPTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAVADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAVADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAVADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAVADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVRRRETARLLRRPRAAVSTLLPLLSAAADTEVGQATAQRAAVLRLAAAGVTRPPPRNI*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-