Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.2 1.1e+03 -0.3 0.3 35 42 40 47 31 57 0.54

2 3 1.3 7.2e+03 -2.9 0.1 30 38 74 82 67 88 0.42

3 3 7.4e-17 4.2e-13 49.2 6.6 3 70 107 171 105 171 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.2	1.1e+03	-0.3	0.3	35	42	40	47	31	57	0.54
2	3	1.3	7.2e+03	-2.9	0.1	30	38	74	82	67	88	0.42
3	3	7.4e-17	4.2e-13	49.2	6.6	3	70	107	171	105	171	0.94

Coding Sequence: ATGTGCGAGGGTTTCGGGTTCCAAAAAGAGATTAAAGCACACCTTGCAGCATCTCGTTCCAAAGATTCCTTCCCCCTCCCACGTCTTCTCTATCTCCTTCCACGTCGAGTCCTTTCCTTCATTTTTGTTTTTTGTTGTCTTTCTCGGATTTCTTTTCTAACCTCCTCCCATCCTCACCCAGAGTTGGCAGGAGGGAGGCGGACGGAGAGGACTCGGGTTCTCTTTTTTTTTCTACTACTCCGAACGATGTGTTCTTTCACCGTGAAGCCAGATGGCAATTTCGGTTCGCCGAGTAAAACCGTTCTCAACAGTCCGCTGCCGGTCACCAAATACTGCTACTTCTGCAAAAGAATCGTCTGGACGAAGATCAAGTACTACCCGACGTTCAAGACTAGAGTCCTAGCTCTCGGATTGTCGTTTTGTTTACTTTGCTGGCTTCCGTTTTACTTCCACTGGAAATCAGAACTCGATCATCACTGCACCTTCTGCGATTGCTACCTAGGAACCTACGACCCAACGTTTCAAAATAGTGATATCGAAGCACTGTTATCCCCAGTTCCGGTTGATAGAACCGATGAGAAGAAACAACCTCAGAAAAAGTATAGAGAAGTCGGTCGAAGGTGTGGAGACTATCCAGAGACCATGGCGGAAAGAGATGAAATAATGAGAGTGTATAGCGATGTTCTGCACTAA
Protein Sequence: MCEGFGFQKEIKAHLAASRSKDSFPLPRLLYLLPRRVLSFIFVFCCLSRISFLTSSHPHPELAGGRRTERTRVLFFFLLLRTMCSFTVKPDGNFGSPSKTVLNSPLPVTKYCYFCKRIVWTKIKYYPTFKTRVLALGLSFCLLCWLPFYFHWKSELDHHCTFCDCYLGTYDPTFQNSDIEALLSPVPVDRTDEKKQPQKKYREVGRRCGDYPETMAERDEIMRVYSDVLH

Sequence clustering based on sequence similarity using MMseqs2