Basic Information

Insect: Columbicola columbae
Gene Symbol: MBD-R2
Assembly: GCA_016920875.1
Location: JADMLL010000001.1:19661428-19666202[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1e-12 2.5e-09 36.5 0.3 8 69 366 425 361 431 0.93

2 3 2.7e-09 6.5e-06 25.6 0.1 9 69 503 558 500 566 0.84

3 3 1.4e-16 3.4e-13 48.9 0.0 8 70 644 704 641 708 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1e-12	2.5e-09	36.5	0.3	8	69	366	425	361	431	0.93
2	3	2.7e-09	6.5e-06	25.6	0.1	9	69	503	558	500	566	0.84
3	3	1.4e-16	3.4e-13	48.9	0.0	8	70	644	704	641	708	0.96

Sequence Information

Coding Sequence: ATGAGGATAATGAAATCACTACCAGAACAAAAGGAGGAAAGTACTACATCAGCCAAAACCAATCTAATATTATCTTCAAAGGAAAACAGTTGTTTATTCAATCATATTGACAAACTAGCAGCAGATCATGATGTAACTGTGTCTCAGACTATGATCAAAGTGACTTATAAAAAGCCATCAAGGGAATATTATGCATCACGGTTATCTGAAAATGGAGTCAATTTCTGTGATGAGTCAACAGTCAATCTTGCTACACCCTCTTCTGTGAAAAAACCAGTAGAACACAATAAAAAGAATCAATCAGCACAAGCAGACTTAAGCAAAAGTGACATGTACAATAGTGACTTTGTGTTAGTTCCTGGCAATATAAAATCTCCAAACATGAGTAAAGAATGTGGTAAAACTTCAGTATTTCATTCTACTCCAAAGCAAAATTCAGAAGGAGTTGATAAGAAAAAGGAGTATATCAATGGTCTTAACCTTGTGGTCGACTTAAGTAAGTGTCACATCAAAAATACAGAAGCTAATGGTCACAGTCCCATCAAAGTTCGTACCACTTCTTCATCAGCAATAAATTCTACTGATAAGGCACCATGTCAATCAAATTCTAGTACTAAAAATCAACAAAAAAATGTAACAGACAAAAAATTAAATGATTCGGGGAAACTTCATTCTAATAGTATTAAGTTCCTAAAAGGTGTTACCCTTGTTAAATTGGAAGACAGTATTAATTCCCAACACTGTTCATTAGGAAAAAAATCAGAACAGAAATCAGATCCTAAAAAATTGAACTCAAAACCTAAAAAGGATACCAGTGATAATGGTTCTGTCATAAAAAGTGTTAAAAAAGTTGAGGGTGCAATAAAGAGAAAAATAAAAAGTGAAGAAAATACTTTTCCAAATAAAAAAATTAAAAAAATTGAGGGAAACTCACAAGATTTAAAAAAGAAACTCTTAAACACACAATCAAAAGCTGTGGTTAGGGATAAAAAAATAAAAACAAGTGAGAAAGATGATAATTCAGTTAAAGATAAAGAGAAATCAGAAGAAAACAGTAGTAGTAATGTACCGAAGGAAAAGGAAATATTATTGGAAGACCCAACTCTTCCATCAGGATGGAAAAGACTCATTCACACAAGACATAAAGGCTCACCTAATGAAAAGCATGTTGTTTATATTTCCAGTCCTCAAGGTAAGAAGTTTCAATTTAGATGGAAACTCAGAAGATTTTTAGAAAAAACTAAATCTCCTCTCAGTGCTGACCAATTTTATTTTGGTCTTTATGGAAGAAGGAAGCCATATGTGCCTGTTACATATGAGGAGAAATTAAACAACACACCAAAAAGCTCATCTGATAATGAGGCCTCATGCATCACAATGAAAACTAAATCTTCAAATTCTCCGGTTCTTAGAAAATCTGAGAAAGGCACACTTGCAATTGGTGCTGGTGTCAAATCACCAGCCAAGACTATGATGTCAGAGGGGAAACAAATTTTGCTGTTTGATCCAGATCTGCCATACGGATGGAGGCGAATTATTAATTCAAGTAGTCCTAATGGAAAGTTGCAAGTTCATATCATAAGTCCGGATGGAAGAATATTTCGTCGAAAATATCGGCTACTCGAATATCTTTCTAAACATCAATTCACGCATAGTTTAGACCGTTTCTACTTTGGGCTGTATCCAAAGAAAGATCAACTTAATACTTCCAAAAGTGTAGAAAATGGTAGCGTGTCAGCGGATAGCGTAACAGTGGAGGGAAAGACAAAATCAGATGTTCATAATGAAAGTGACATTAAAAATGAATTAAATACTTCCGATTCGTCCAGCCGAGCTTCGCTTAATACTACGGATGACAATGATGGTGAAATGTTTATGTTGGAAAAGGATGTGTCACAACTTCAGCAATACGGGTCTCCCATGTACGAAGATCCTAATCTACCGGAGGGGTGGAAGAGGTTCATAAAGGTTAGGGCTTGTGGCGAAAGCGCGGGAAAAATGGAAGTTATTATTGTCAGTCCCGATGGCAAAAGACATAGATCTAAAGGAAACTTGGAAAGCTATCTCAAACAGAATAATTTGAGTTATAAAGCGGATGATTTTGACTTCTCCGTGTTTGGGAAAGGAAGGAGACGTTCACTACCACAACGATCGGATTCGCTAAAAGATATAAATCTTGAGATAAGGAGAAAACCCAAAGTTGCTTCCGATAGACCTGTACCTGACTTTGATATTAATAGTATAAAGCATGTAGAGCCCACTAAGGAGGGCAAAATGATAAATGAAGTTAGTGGAATAATGATAAATTGTGGATTGTCATCGGCTAGAAGCGAACGCCGATTGAGGTTACCAAGGCGTGAACATGAAAAAATTGTAAAAGATCACCTAAATTCAGAAGGTGATATTTCAAACGATGGTTGTGATGTTCCAACATATTGGATACAAAGATTAGTTAAATGTCGTAGTGATTTTCGAATTTTAGAAAGCGAAGCGGCGGCTACTATAGCAGAGAAAACTAAAGAATTCCTTAAAGAAATATCCTCAAGAGCTTTTAAAAGTTCCCAACACCCTGAGGAAGGTTTGAAATACAAGGATGTGGCAGATATTGTCGAAAATTCTCAGTGTTTGTCTCCTCTAAAAGAACTCATTCCCAAAAAAATTACTTACAAAGAATACGTCCAATTAAACAGACCTAAGCAATTTATGTCATTCACTTGA
Protein Sequence: MRIMKSLPEQKEESTTSAKTNLILSSKENSCLFNHIDKLAADHDVTVSQTMIKVTYKKPSREYYASRLSENGVNFCDESTVNLATPSSVKKPVEHNKKNQSAQADLSKSDMYNSDFVLVPGNIKSPNMSKECGKTSVFHSTPKQNSEGVDKKKEYINGLNLVVDLSKCHIKNTEANGHSPIKVRTTSSSAINSTDKAPCQSNSSTKNQQKNVTDKKLNDSGKLHSNSIKFLKGVTLVKLEDSINSQHCSLGKKSEQKSDPKKLNSKPKKDTSDNGSVIKSVKKVEGAIKRKIKSEENTFPNKKIKKIEGNSQDLKKKLLNTQSKAVVRDKKIKTSEKDDNSVKDKEKSEENSSSNVPKEKEILLEDPTLPSGWKRLIHTRHKGSPNEKHVVYISSPQGKKFQFRWKLRRFLEKTKSPLSADQFYFGLYGRRKPYVPVTYEEKLNNTPKSSSDNEASCITMKTKSSNSPVLRKSEKGTLAIGAGVKSPAKTMMSEGKQILLFDPDLPYGWRRIINSSSPNGKLQVHIISPDGRIFRRKYRLLEYLSKHQFTHSLDRFYFGLYPKKDQLNTSKSVENGSVSADSVTVEGKTKSDVHNESDIKNELNTSDSSSRASLNTTDDNDGEMFMLEKDVSQLQQYGSPMYEDPNLPEGWKRFIKVRACGESAGKMEVIIVSPDGKRHRSKGNLESYLKQNNLSYKADDFDFSVFGKGRRRSLPQRSDSLKDINLEIRRKPKVASDRPVPDFDINSIKHVEPTKEGKMINEVSGIMINCGLSSARSERRLRLPRREHEKIVKDHLNSEGDISNDGCDVPTYWIQRLVKCRSDFRILESEAAATIAEKTKEFLKEISSRAFKSSQHPEEGLKYKDVADIVENSQCLSPLKELIPKKITYKEYVQLNRPKQFMSFT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -