Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.8e-21 2.2e-17 63.2 0.0 1 74 9 88 9 91 0.89

2 2 5.1e-05 0.24 11.9 0.0 28 76 179 238 150 239 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.8e-21	2.2e-17	63.2	0.0	1	74	9	88	9	91	0.89
2	2	5.1e-05	0.24	11.9	0.0	28	76	179	238	150	239	0.88

Coding Sequence: ATGCAAATGAATTCAAGTATCACAATTGAACGCAAGCGCGTTGATTGCAGTGCATTACCAAAAGGCTGGCAGCGAGAGGAGGTGCGAAAATCATCTTCGTCTGCCAAcaccagcagtggcagcaacaacaacaacaaggtggATGTTCTTTATTACAGTCCAACAGGCAAGCGTATTGACAGTAAACCACAATTAGCTCGACAGTTGGTTGATGACATTGAAATGTTCGACATTAGTAATTTTGATACCCAAACGGGCAGAATGCCAAGTCGCCcatcaatgccaatgccaatgccatcgCCCTCCATATCGCTTTACCGCTGCAGCACAGGTCCACGGCCTATTAGTGGCTCCACGGTCTCGGCCGCAAGTGCCGCCCTAAAACGAAAATACGCAAGAGCACAAAACCAGgccaacagtaacaacagcagcagcgcatcATCAGCAACGGCATCTAACGTATTGGCAGCTAATCttcgccagcaacagcagcaacaacagcagcagcagcaacaacaagctgaATTCAGTCGTACCCTGCGCACAGATGTCTCTCTGGTCCCCCCCATACGGCAGACAGCGTCGATTTTCAAGCAGCCCGTTAGCGTAGTGCGTAATCATGAACATGATGCCAGCAAGTACAAGCACGATGCCAAGCATGGCGTCcaggaaaaaccaaagcaaatgttttGGGAGAAGCGCTTGGAGCGCCTGCGAGCCTGTCATGACAATGGTGAGGAACTGGACGATATAACACTACCAAAAACCATTCGCACCGTTGGACCCAATGTTAACGAACAGACTGTACTGCAATCGGTGGCCACTGCCCTGCACATGCTCAATGCCGGCGTACATGGACAGAGCAGCACTAAGGCTGAGCTTACCAAGAATGCCATGGCGTTCATGAACCCCGAACAGCCCCTCATGCATGCGGTTATTATCTCCGAGGACGACATACGCAAACAGGAGGATCGAGTGTGCGTGGCGCGTCGAAAGCTGCAAGATGCCCTCAAAACATAA
Protein Sequence: MQMNSSITIERKRVDCSALPKGWQREEVRKSSSSANTSSGSNNNNKVDVLYYSPTGKRIDSKPQLARQLVDDIEMFDISNFDTQTGRMPSRPSMPMPMPSPSISLYRCSTGPRPISGSTVSAASAALKRKYARAQNQANSNNSSSASSATASNVLAANLRQQQQQQQQQQQQQAEFSRTLRTDVSLVPPIRQTASIFKQPVSVVRNHEHDASKYKHDAKHGVQEKPKQMFWEKRLERLRACHDNGEELDDITLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVCVARRKLQDALKT

Sequence clustering based on sequence similarity using MMseqs2