Basic Information

Gene Symbol
-
Assembly
GCA_905220415.1
Location
HG991985.1:892474-909037[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 1.4 1.1e+02 3.9 0.1 5 23 389 407 388 407 0.94
2 8 9.1e-06 0.00072 20.3 2.0 1 23 446 468 446 468 0.99
3 8 7.6e-05 0.006 17.4 8.9 1 23 475 497 475 497 0.98
4 8 8.3e-06 0.00066 20.4 0.1 1 23 503 525 503 525 0.93
5 8 4.7e-06 0.00037 21.2 0.1 1 23 531 553 531 553 0.98
6 8 7.9e-06 0.00062 20.5 2.0 1 23 559 582 559 582 0.96
7 8 0.00011 0.0086 16.9 0.5 2 23 606 627 605 627 0.97
8 8 0.00018 0.014 16.2 0.5 1 23 633 655 633 655 0.96

Sequence Information

Coding Sequence
ATGGCAGAGCATTGTTATATTTGTAATAAGCAAGATGGAGGGGTGGAGAAAACAAAGATTAACATATTTGAAACCAAGACACCTATGTCAGGAAGTAAAATATTTGAGCTGTTATTAGAAATATCAGGAAAGGATGTGCCACAGGAATGTAAGGAAAAGAATAATTTGTGCGCAAAATGCTATAAATCACTTCTCGAATATGATTATCTGCTTGCTAGGCTTAACGAAATGAAAACATCAATTCGCGAAAACATACATAAATCGGAACAGTTGCGAAACATCAAAAAGGAATTGATAGTAGACGACGCAAAAGCAAAAGAGAAAAGTAATATAAAGCTAGTGTTGCCCGCGTCAAAATTGCAGCCTCTGCCGCCCGGGTTCGATTTGAGAGTTCAAACTTCGACCAGTTGGAGTAATGTGTCTACTACAAATGTCCCCAAAAGTATGCCGTCAATATCAAGTTTACCGAACTTAACAGAAACCACAGACGCATCAGAAACAACATCAACAATTAAAACAGAAATGGATATAAATCAATTATCAAGCATACCAAGAGTGATTATAGAACGTGAGACGATCGCAACACTATTAAATAAAGGCAATTTCACCCTAAATGGTATAGCCAAGGGCTATGTTAGAGTGACGAATGAACAAAAAGACGAGGAAAACCCTGAAGAGAAACCTATGGAGATTGATGAAGACGCGGTTGTAATAGCGAGTGAAAATGGTCCCATAATAGGTGTGGTGTCGGGGCAAAAGTTTATATACGGAGATAACGAGATATCATTGGTTGTGCCCCATGATAACGATAGCTTGGACAATAACGACGATCAAGATTCAAACTCAGAATCGCACATAGAGTTGCAAATGTCAGGCGATGAAGAAACAGCTAATGCTATCATAGCCGCTGCTAATGAACAAGGTGCCTTCATAAAAGTGGATTCCGGTGAAATGTATGAAGTGAAATCTGTTGAGAGTAAAATAGGAGATAGCAGCCCTAGTAGCGAGATGCCAATACAAATGGTGGAACAGGAGGGTGATAAATTTAAATGTCTGCTGTGCGAGAAAAGTGCCAAAGCAGATTCCGAGCCAGAATTATTAGATGATGCAGTCGCAACGATGAAACACTTGAAATCAGTGCACGGAGCGAGATTGTACATATGTCAGTGTGGTGTTATGTTGAGACGGAGGGCTGATTATGTGCAGCATATTGAACAACACGCGGAGAAATCAAATCAAATTGTACAACCTGCTGACAAGAGCAAAACCCATGAATGTAACGTTTCACGGTTACTGCTAAACGAACACACAAACACACACACAGGCAAGCGTCCGTACACTTGTGAAATTTGCAACAAGTCCTTTGCGTCGAGATATACGCAGCAGTCACATTTGAAAACTCATCTTGAACGTCCACGTCCATTCAAATGCAATCAGTGTGGAAAATCGTTTTTCACACAACACAATTTACATCATCACGAGAAGATACATTCTGCCACTAAAGATTTCGTGTGCAATGTTTGTGGAAAAGCGTTCGGCACACAACACAATCTAGAAGTACACGGTGTAGTACATTCAGGCAAGAAGCCGTTCGTCTGTACGGTTTGTGAAAAGGCATTCGCCAGACGGGCTGAGGTTAGAGACCATATGCGTATACATACTGGCGAGCGTCCGTTCGAGTGCGAGACGTGCGGGGCCCGCTTCTCGCAGCGCTCGAACCTGCACTCGCACCGGCGCGCCACGCACTTGGACGACAAGCGGCACCATTTGCTAGACTACCACATAAAGTCGAGTCACACAGGCGAGAGGCCGCTCAAGTGCGAAGTGTGCGCCGCTACATTCGTGTATCCGGAGCATTATAAGAAACATATAAGGATACATAGCGGCGAGAAACCGTACATTTGTGAGGTGTGCGGCAAGGGCTTCAACTCGCGCGACAACCGCAACATGCACCGCTTCGTGCACTCGGACCGCAAGCCGTACGAGTGTGGCCACGTGTCGGAGTCGATCGTCATCAACCAACCGCGAATTAGCAAACTTGAAGATAATGAAATTAAAACGCAATCTGTCATCGTGCGGGATAAAAAGAAAGACGATAAACTTATGGAAACCATTTACGAATCGGCAGATGTTTTAGAACTCGATTCTGCAGAGAAAGTTGTTGAATTGGAAGGGGAAGACAATATAACAAAATATGTAATAAGTACGGATAAAAAGTTCATGATGTCTGATGGAAAATCATTGAACTTGGTGCCTGAAGTTGAAGGTGAAGAAACAGCCTTGCTAACTATACAGCAATTGGAAGGTATTGAAAAAATAGAAGGAACTGTTTTGGAGAATATCACAGCAGAACAACTGGAACAAGCCCATATACTAAGCGACGGCAACAACACAGTTCGTTTGATTCAAATACAACTAGCGGATGGGAACAGCGGTTGGGTAGCTGTCAGTCAATAG
Protein Sequence
MAEHCYICNKQDGGVEKTKINIFETKTPMSGSKIFELLLEISGKDVPQECKEKNNLCAKCYKSLLEYDYLLARLNEMKTSIRENIHKSEQLRNIKKELIVDDAKAKEKSNIKLVLPASKLQPLPPGFDLRVQTSTSWSNVSTTNVPKSMPSISSLPNLTETTDASETTSTIKTEMDINQLSSIPRVIIERETIATLLNKGNFTLNGIAKGYVRVTNEQKDEENPEEKPMEIDEDAVVIASENGPIIGVVSGQKFIYGDNEISLVVPHDNDSLDNNDDQDSNSESHIELQMSGDEETANAIIAAANEQGAFIKVDSGEMYEVKSVESKIGDSSPSSEMPIQMVEQEGDKFKCLLCEKSAKADSEPELLDDAVATMKHLKSVHGARLYICQCGVMLRRRADYVQHIEQHAEKSNQIVQPADKSKTHECNVSRLLLNEHTNTHTGKRPYTCEICNKSFASRYTQQSHLKTHLERPRPFKCNQCGKSFFTQHNLHHHEKIHSATKDFVCNVCGKAFGTQHNLEVHGVVHSGKKPFVCTVCEKAFARRAEVRDHMRIHTGERPFECETCGARFSQRSNLHSHRRATHLDDKRHHLLDYHIKSSHTGERPLKCEVCAATFVYPEHYKKHIRIHSGEKPYICEVCGKGFNSRDNRNMHRFVHSDRKPYECGHVSESIVINQPRISKLEDNEIKTQSVIVRDKKKDDKLMETIYESADVLELDSAEKVVELEGEDNITKYVISTDKKFMMSDGKSLNLVPEVEGEETALLTIQQLEGIEKIEGTVLENITAEQLEQAHILSDGNNTVRLIQIQLADGNSGWVAVSQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00357893;
90% Identity
iTF_00357893;
80% Identity
-