Basic Information

Insect: Colias behrii
Gene Symbol: pax2-a
Assembly: GCA_029959075.1
Location: JARWMB010000027.1:1250064-1296605[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.4e-73 3.9e-70 234.5 0.5 2 125 51 174 50 174 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.4e-73	3.9e-70	234.5	0.5	2	125	51	174	50	174	0.99

Sequence Information

Coding Sequence: atgtgtgttttgTACAAACGTGATTGTGCCGGCAAGCTGGAGGGCCAGGGTAAGGCCACTTTCGCGGCCCTTTTCGGGCTGAGGGCCGGCGGCGTTGACCTCTCCGCCGCGTATCGATATAATCAAAATATGATGGAGTATTATACatGCCACGGCGGCGTCAACCAGCTCGGCGGTGTCTTCGTGAACGGCAGACCTTTACCAGACGTGGTCCGGCAGAGGATAGTAGAACTGGCGCACAGTGGAGTCAGACCTTGTGACATTAGCAGACAGCTGAGGGTCTCCCATGGCTGTGTGTCGAAGATTCTGTCTAGGTACTACGAAACGGGTAGCTTCAAAGCCGGCGTGATAGGGGGTTCGAAGCCGAAGGTGGCCACCCCACCCGTGGTGGACGCTATCGCCGCATACAAGAGGGAAAACCCGACGATGTTCGCCTGGGAGATCCGGGACAGACTGCTGAGCGAGGGGATCTGTAGCCAGGATAATGTGCCGTCTGTGTCCAGTATtaatagGATCGTGCGCAACAAAGCAGCAGAGAAGGCAAAACACGCGCACAACCAGCAGCAACAACAACAACAGGAGCAGGAGATCAGCTCCGCGCAGGGGAGTGTTGTTTCTGTAATAACGCACGCAGGCAATGCTGGGACCACCGCCGTGCTGTCTCCAACCACGGAACAGCACGTCACCAATACTGGCAGCTACAGCATCAACGGGATCCTGGGGATCGAGCAGGTGGAAGGTCTGCATAACGGGAACGGGCTGAAGAGGAAACGGCATGAGGATCAGGATGAGAACAGAGATTTCAATAGTCATTCAGAAGACGACGTGAAGCGACAGAGAAGTCACTACAACGGCGACCAGATATATTCTAacGTTCCCTTCCAGCTGTGGTCGTCTTCGAAGTGGAGTCTAAAGGACGAGTACAAGCTGCTCTCAGAGCTGGGGGGAGGGACGGGATACTACGGGGAACTGTTCGAAGCGCCCTATGAACATGCCGCTCATCCGCATTATGCACCGCATTCTGCGGGCACAAACGACTCAACGGGGTCGGCCGCGGGCCCCGGCGAGCCGCCGTCCGCGGCGGGCAGCCCGGACGCCGCGGCGCTCGTCGTGCTGCAGCCGCCCGCGCCGCCATACCCGCCTTATGCGCATTATGATGGTACAGCCACACTAGCGAGCGAGTACGCGTACGCGGCCCCGTACTCGCAGTACTCGCCGTACGGAGGGCCCTACTCACATTCCGCGGCCACGGGACTTCTATCCAAGTGGTAA
Protein Sequence: MCVLYKRDCAGKLEGQGKATFAALFGLRAGGVDLSAAYRYNQNMMEYYTCHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVSSINRIVRNKAAEKAKHAHNQQQQQQQEQEISSAQGSVVSVITHAGNAGTTAVLSPTTEQHVTNTGSYSINGILGIEQVEGLHNGNGLKRKRHEDQDENRDFNSHSEDDVKRQRSHYNGDQIYSNVPFQLWSSSKWSLKDEYKLLSELGGGTGYYGELFEAPYEHAAHPHYAPHSAGTNDSTGSAAGPGEPPSAAGSPDAAALVVLQPPAPPYPPYAHYDGTATLASEYAYAAPYSQYSPYGGPYSHSAATGLLSKW

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01561971; iTF_00771046; iTF_00876137; iTF_00875275; iTF_00874429; iTF_00358527; iTF_01205666; iTF_00878818; iTF_01204002; iTF_01204848; iTF_01202431; iTF_01033704; iTF_01438893; iTF_00044466; iTF_01437941; iTF_00710167;
90% Identity: iTF_01437941;
80% Identity: -