Basic Information

Gene Symbol
-
Assembly
GCA_947284805.1
Location
OX369278.1:3961611-3963998[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 6.3e-06 0.00059 21.5 4.2 1 23 7 30 7 30 0.95
2 20 0.00051 0.048 15.5 0.4 2 23 36 58 35 58 0.94
3 20 1.2e-05 0.0012 20.6 0.3 2 23 67 89 67 89 0.97
4 20 5.5e-06 0.00052 21.7 0.6 2 23 98 120 97 120 0.94
5 20 4.5e-05 0.0042 18.8 0.7 2 23 128 150 128 150 0.95
6 20 9.1e-06 0.00086 21.0 0.9 2 23 158 180 157 180 0.96
7 20 4.9e-07 4.6e-05 25.0 0.5 1 23 186 209 186 209 0.98
8 20 0.0013 0.13 14.2 2.0 1 23 217 240 217 240 0.94
9 20 0.00011 0.01 17.6 2.9 1 23 263 286 263 286 0.98
10 20 0.0022 0.21 13.5 0.4 1 23 317 340 317 340 0.97
11 20 2 1.9e+02 4.2 1.0 2 21 348 367 347 368 0.92
12 20 0.027 2.5 10.1 2.2 2 23 377 399 377 399 0.95
13 20 0.00049 0.046 15.6 5.3 1 23 423 446 423 446 0.97
14 20 0.00037 0.035 15.9 0.9 2 23 453 475 452 475 0.96
15 20 0.00011 0.01 17.6 4.0 2 23 482 504 481 504 0.94
16 20 0.011 1 11.3 2.2 1 23 510 533 510 533 0.97
17 20 0.35 33 6.6 4.8 2 23 541 563 541 563 0.95
18 20 0.0008 0.076 14.9 0.4 1 23 570 593 570 593 0.96
19 20 0.014 1.3 11.0 2.3 1 20 600 619 600 623 0.90
20 20 0.034 3.2 9.8 2.2 5 23 640 659 637 659 0.89

Sequence Information

Coding Sequence
ATGTTCGCCAATTTAGACTTCGTGTGTGATTATTGCAGCCGCACATTCACGAGGAAGTATAATTTACAGACGCATATAGAGAACTGTCATATAAACTCTTCGTGCTCCTGCAATGTTTGTGGCCAAACCTTTGGCAGTCCGGCTGGATTGCAGCTGCATTACAGTCGCGGCCACAACAGATACAGCCAGCCGTTCCCCGAATGTGACATATGCGGTCGAATATTCACACGGAAACAAAATATTATGTCGCATATGCTCACAGTTCACTTACATGGTATCGGCCCAGAAATACGTTGCCAGTATTGCGATAAAGCATTCGCTACAGAAAGGAATCTTAAAAGACATGTCAATCAGCTACATAATCCAGATGTGGAATATCCTACTTGCGATGAATGTAATAAGGTCTTTAAAGGTAAACACTCACTTATAGCTCACATTCAAGCTACACACAATACGGAAAAGTGTGTTAACAAATGCGAACTCTGTGACAGAGCTTACACTAACAGCAGGAACTTAAAAAGACATATCGAAATGTTTCATGGCGAAAAAGAAGAATTCAAATGCGAAATTTGTCCAAAAGTGTATACTTCTAATCAGAGTTTGAGAAGACACGCAAGGACGGCACATAATGCTGATAATCAAGATGAATACAGATGTGATTATTGTCTGAAATCATTTAGCGGAAAGGACAACTTCGATAGTCACGTACAGTTCTATCACGGAAATGAAAACACCAATTCAAACGATTCCAACACAAACGGTATGTCACTGGACGAGAATTTATTTTTCAGCTGTGAAAATTGCCACAAATGCTTTGACGATGAACCAACGTTAAGAGCTCATGTAAAGACTGAACATTCTTTCGAAATCTTCTACGACTACTGCAGGAAATCACTTCTAAGACAATACGCCGAAAACCCGCCGGAAAGACATAAAACAACCTGTTTCTATAATTGCGAATTCTGTAGCAATGCTTTTATAAGTGTATACGAATTGAAAGATCACATGAAAGTGAGCCACGAAAAAGAATACTGTCTGTCTACTTGCAATGTGTGTTTCAGCAAGTTTTATAGCAAGGAAACTATGTTTGAGCATAAAAAAATATGCATCCCACCAGATAATGTAAACTCTTGCAGTCACTGTGACAAACTCTTCACAGATATATCGAGCTTGGAGTTTCATACTCGTATTTTCCACCCACAAGCGCAAATCGCCGATTCTAATATCACATCAACCAACATCGATGACTCTTTGGATGGTGGAACCTTTAGGTGTGAACACTGCGACAGAGTTTACTACAGCGAAAGGTCACTAAAACACCATATAAAATTGAAGCACAGTACCGATGAGGAAGTCGAATGCCAGATATGCAGCAAAATCTGCAACAATAAGTATTATTTGGCATCACACATAAAAATGGTTCACAACAACGATAGCTGGTCAAAATGTGATTATTGTGATAAACACTTTAAATCAAAGAGGAATATACGACGACACATTGAATACACACATCTGGGAATGCAAAGATACAAGTGCATTGAATGTGAAACCTTGTTCAAAGAGAAAAGGAGTTTAAGGAAGCATGTACGGACTAAACATCCAAACTCTGCAACGTTTCCTCAGTGCCACATCTGTTATAAGCGTTTCGAATCGGCAAAATCGTGCAAAATACATCTGAAGTTATTACATTCGTTCAACATGAACACTTATCCTTGTCACTTATGTTCAGTATCCTTCAGCTCGAATGTGGCGTTGAGTATCCACCTGGGCACAAAACATTTAGCTGAAGATGAGATTTACAAATGCGAAGAGTGCAATCTGGTTTTCAAAGGACAGGAAAAGTTTGAGCAACACAACGACTTATGTCACGTCAATCTAGTTCCGAACATCAAACAGAAGGCGTTACCTCGCTGTATTATTTGCATCAAAGATTTTAGTACGCGTAAAACTTTAAAACGCCACATTAAGAAGTTCCACGATGGATTCGATGTTGATGAATTAGCTACGTATGGCTCTCGAAAACGCGTTTTCAATGTAGAATGTGAGGATTGCATTAAAAAGTTCAATGACGACTTTCATTACAACATCTATCTGAAACTAAAACACTTGCGCGATTCAGTTATATTTAAGTGTGAGACCTGTTGCTCCTCTTACAATTCTATCGAGTACTCGATACAGCGATACAAGTTGGTGAACTTCGAGTTGTACAGAAGCAAGATGATTCTAAGTGAGTTGTGTACAGCGGAAATGAGTGATGCTGACGACGGAGAAGCAACGTCTTCAGGGATTGAGTTGCAAAGTGAATCGATGGAACCGGAGAGCACGACAGTCGACGTAAAAGATGAACTGGAAGTGTTAGATGTAAAGGTTGAGCCTATATCTCCGTAA
Protein Sequence
MFANLDFVCDYCSRTFTRKYNLQTHIENCHINSSCSCNVCGQTFGSPAGLQLHYSRGHNRYSQPFPECDICGRIFTRKQNIMSHMLTVHLHGIGPEIRCQYCDKAFATERNLKRHVNQLHNPDVEYPTCDECNKVFKGKHSLIAHIQATHNTEKCVNKCELCDRAYTNSRNLKRHIEMFHGEKEEFKCEICPKVYTSNQSLRRHARTAHNADNQDEYRCDYCLKSFSGKDNFDSHVQFYHGNENTNSNDSNTNGMSLDENLFFSCENCHKCFDDEPTLRAHVKTEHSFEIFYDYCRKSLLRQYAENPPERHKTTCFYNCEFCSNAFISVYELKDHMKVSHEKEYCLSTCNVCFSKFYSKETMFEHKKICIPPDNVNSCSHCDKLFTDISSLEFHTRIFHPQAQIADSNITSTNIDDSLDGGTFRCEHCDRVYYSERSLKHHIKLKHSTDEEVECQICSKICNNKYYLASHIKMVHNNDSWSKCDYCDKHFKSKRNIRRHIEYTHLGMQRYKCIECETLFKEKRSLRKHVRTKHPNSATFPQCHICYKRFESAKSCKIHLKLLHSFNMNTYPCHLCSVSFSSNVALSIHLGTKHLAEDEIYKCEECNLVFKGQEKFEQHNDLCHVNLVPNIKQKALPRCIICIKDFSTRKTLKRHIKKFHDGFDVDELATYGSRKRVFNVECEDCIKKFNDDFHYNIYLKLKHLRDSVIFKCETCCSSYNSIEYSIQRYKLVNFELYRSKMILSELCTAEMSDADDGEATSSGIELQSESMEPESTTVDVKDELEVLDVKVEPISP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00356662; iTF_00355454;
90% Identity
iTF_00356662;
80% Identity
iTF_00356662;