Basic Information

Gene Symbol
-
Assembly
GCA_947284805.1
Location
OX369291.1:12175503-12177218[-]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.016 2e+02 2.9 0.1 10 23 18 31 17 33 0.89
2 19 0.016 2e+02 2.9 0.1 10 23 47 60 46 62 0.89
3 19 0.016 2e+02 2.9 0.1 10 23 76 89 75 91 0.89
4 19 0.016 2e+02 2.9 0.1 10 23 105 118 104 120 0.89
5 19 0.016 2e+02 2.9 0.1 10 23 134 147 133 149 0.89
6 19 0.016 2e+02 2.9 0.1 10 23 163 176 162 178 0.89
7 19 0.016 2e+02 2.9 0.1 10 23 192 205 191 207 0.89
8 19 0.016 2e+02 2.9 0.1 10 23 221 234 220 236 0.89
9 19 0.016 2e+02 2.9 0.1 10 23 250 263 249 265 0.89
10 19 0.016 2e+02 2.9 0.1 10 23 279 292 278 294 0.89
11 19 0.016 2e+02 2.9 0.1 10 23 308 321 307 323 0.89
12 19 0.016 2e+02 2.9 0.1 10 23 337 350 336 352 0.89
13 19 0.016 2e+02 2.9 0.1 10 23 366 379 365 381 0.89
14 19 0.016 2e+02 2.9 0.1 10 23 395 408 394 410 0.89
15 19 0.016 2e+02 2.9 0.1 10 23 424 437 423 439 0.89
16 19 0.016 2e+02 2.9 0.1 10 23 453 466 452 468 0.89
17 19 0.016 2e+02 2.9 0.1 10 23 482 495 481 497 0.89
18 19 0.016 2e+02 2.9 0.1 10 23 511 524 510 526 0.89
19 19 0.016 2e+02 2.9 0.1 10 23 540 553 539 555 0.89

Sequence Information

Coding Sequence
ATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACACTTCATACAACGGGCCAGAAATGACATTTCAAAAAAGGAATGACGGAACAAACAAAATGGCGGCGAAATCTTATACGTTCGACAACCAAACTGTAACCAATCTGTATCGATCTGGGTGA
Protein Sequence
MAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNTSYNGPEMTFQKRNDGTNKMAAKSYTFDNQTVTNLYRSG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-