Basic Information

Insect: Coenonympha glycerion
Gene Symbol: NR2E3
Assembly: GCA_963855885.1
Location: OY979631.1:11837374-11841630[-]

Transcription Factor Domain

TF Family: RXR-like
Domain: zf-C4|RXR-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 4e-32 1.9e-28 100.3 0.4 2 115 153 258 152 280 0.87

2 7 1.5e-07 0.00072 20.0 0.0 84 115 276 307 260 322 0.83

3 7 6.3e-08 0.0003 21.3 0.0 83 115 324 356 312 368 0.86

4 7 1.7e-07 0.00082 19.9 0.0 83 115 373 405 358 420 0.84

5 7 1.9e-07 0.00089 19.8 0.0 83 115 422 454 407 466 0.85

6 7 5.6e-08 0.00026 21.5 0.0 82 115 470 503 455 516 0.86

7 7 5.5e-30 2.6e-26 93.3 0.0 83 195 520 658 505 659 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	4e-32	1.9e-28	100.3	0.4	2	115	153	258	152	280	0.87
2	7	1.5e-07	0.00072	20.0	0.0	84	115	276	307	260	322	0.83
3	7	6.3e-08	0.0003	21.3	0.0	83	115	324	356	312	368	0.86
4	7	1.7e-07	0.00082	19.9	0.0	83	115	373	405	358	420	0.84
5	7	1.9e-07	0.00089	19.8	0.0	83	115	422	454	407	466	0.85
6	7	5.6e-08	0.00026	21.5	0.0	82	115	470	503	455	516	0.86
7	7	5.5e-30	2.6e-26	93.3	0.0	83	195	520	658	505	659	0.95

Sequence Information

Coding Sequence: ATGGTATGTACTGGGAGCAACGACGAACTTTATGATGGCGCTGTCCCCGGCGCGCTACCCGCTGCTGTCGCCGCACtacgcgccgctgccgccgccgcagccgccgcaacAGCCGCAGCCAGACTCCTCGCACGACCACCACGACGGCGGCCACGCGCACTCCGACAGCGATGGTATGTACTGGGAGCAACGACGAACTTTATGATGGCGCTGTCCCCGGCGCGCTACCCGCTGCTGTCGCCGCACtacgcgccgctgccgccgccgcagccgccgcaacAGCCGCAGCCAGACTCCTCGCACGACCACCACGACGGCGGCCACGCGCACTCCGACAGCGATGATGACAGTATTGACGTGACCAATGAAGAGGATTCCACATCGTATTCCCCTCCAGCCGTATCCAGCTATTCCCAAAGTTGTATACCATATGGGCCACTTGGCGTAGAAAGTGCGGCGGAAACGGCGGCGCGCTTGCTATTCATGGCGGTCAAATGGGCCAAAAACTTACCTTCCTTCGCCAGCCTTGCCTTTCGGGATCAAGTGATTCTCTTAGAAGAAGCGTGGTCGGAACTGTTTCTGCTGAACGCGATTCAGTGGTGCGCGCCGCTGGACGCCGCGTGCGCCGCGCTCTTCGGCACCGAGCAGACCGACCAAGagaaTGGCACGTCGTCGGTGCTGCGCAGGCTCCGCTCCGTGGTGTCGCGCTACCGCAGCGTGCTGGTGGATCCCGCGGAGTTCGCCTGCATGAAGGCTATCGCGCTGTTCAAGTGCGGTAACTATCCACTATCCATCAACATTGTAGAGAATGGCGCGTCGTCGGTGCTGAGCAGGCTCCGCTCTGTGGTGTCGCGCTACCGCAGCGTGCTGGTGGATCCCGCGGAGTTCGCCTGTATGAAGGCTATCGCGCTGTTCAAGTGCGGTAAATATCCACTATCCATCAACATTGTAGAGAATGGCGCGTCGTCGGTGCTGCGCAGGCTCCGCTCCGTGGTGTCGCGCTACCGCAGCGTGCTGGTGGATCCCGCGGAGTTCGCCTGCATGAAGGCTATCGCGCTGTTCAAGTGCGGTAACTATCCACTATCCATCAACATTGTAGAGACTGGCGCGTCGTCGGTGCTGAGCAGGCTCCGCTCTGTGGTGTCGCGCTACCGCAGCGTGCTGGTGGATCCCGCGGAGTTCGCCTGTATGAAGGCTATCGCGCTGTTCAAGTGCGGTAACTATCCACTATCCATCAACATTGTAGAGACTGGCGCGTCGTCGGTGCTGAGCAGGCTCCGCTCTGTGGTGTCGCGCTACCGCAGCGTGCTGGTGGATCCCGCGGAGTTCGCCTGTATGAAGGCTATCGCGCTGTTCAAGTGCGGTAACTATCCACTATCCATCAACATTGTAGAGAATGGCGCGTCGTCGGTGCTGCGCAGGCTCCGCTCCGTGGTGTCGCGCTACCGCAGCGTGCTGGTGGATCCCGCGGAGTTCGCCTGTATGAAGGCTATCGCGCTGTTCAAGTGCGGTAACTATCCACTATCCATCAACATTGTAGAGACTGGAGCATCGTCGGTGCTGAGCAGGCTCCGCTCTGTGGTGTCGCGCTACCGCAGCGTGCTGGTGGATCCCGCGGAGTTCGCCTGTATGAAGGCTATCGCGCTGTTCAAGTGCGGTAACTATCCACTATCCATCAACATTGTAGAGACTGGCGCGTCGTCGTTGCTGCGCAGGCTCCGCTCCGTCGTGTTATCGCAGCAAACCCGAGGCCTAAAGGACCCGCTGCAGATCGAGAACCTGCAGGACCAGGCGCAGGTGATGCTGATGACGCACGCGCGCGCGGCGCACGGTGCGGCGCCCGCGCGCTTCGGccgcctgctgctgctgctgcctcTGCTGCGCCTCGTGTCGCCGCAGCAGCTGGAGCGCGAGTTCTTCTCCAAGACCATCGGCCACACGCCCATGGAGAAGGTCTTGGCTGACATGTACAAGAACTGA
Protein Sequence: MVCTGSNDELYDGAVPGALPAAVAALRAAAAAAAAATAAARLLARPPRRRPRALRQRWYVLGATTNFMMALSPARYPLLSPHYAPLPPPQPPQQPQPDSSHDHHDGGHAHSDSDDDSIDVTNEEDSTSYSPPAVSSYSQSCIPYGPLGVESAAETAARLLFMAVKWAKNLPSFASLAFRDQVILLEEAWSELFLLNAIQWCAPLDAACAALFGTEQTDQENGTSSVLRRLRSVVSRYRSVLVDPAEFACMKAIALFKCGNYPLSINIVENGASSVLSRLRSVVSRYRSVLVDPAEFACMKAIALFKCGKYPLSINIVENGASSVLRRLRSVVSRYRSVLVDPAEFACMKAIALFKCGNYPLSINIVETGASSVLSRLRSVVSRYRSVLVDPAEFACMKAIALFKCGNYPLSINIVETGASSVLSRLRSVVSRYRSVLVDPAEFACMKAIALFKCGNYPLSINIVENGASSVLRRLRSVVSRYRSVLVDPAEFACMKAIALFKCGNYPLSINIVETGASSVLSRLRSVVSRYRSVLVDPAEFACMKAIALFKCGNYPLSINIVETGASSLLRRLRSVVLSQQTRGLKDPLQIENLQDQAQVMLMTHARAAHGAAPARFGRLLLLLPLLRLVSPQQLEREFFSKTIGHTPMEKVLADMYKN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00354148;
90% Identity: iTF_00354148;
80% Identity: iTF_00354148;