Basic Information

Gene Symbol
USP7
Assembly
GCA_963855885.1
Location
OY979639.1:9294407-9313739[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.015 18 6.2 0.0 20 59 1558 1596 1556 1607 0.86
2 6 0.014 17 6.2 0.0 20 59 1612 1650 1609 1661 0.86
3 6 0.014 17 6.2 0.0 20 59 1666 1704 1663 1715 0.86
4 6 0.018 22 5.9 0.0 20 59 1720 1758 1717 1769 0.86
5 6 0.29 3.6e+02 2.0 0.0 20 54 1774 1807 1771 1821 0.83
6 6 0.095 1.2e+02 3.5 0.0 20 54 1828 1861 1825 1861 0.91

Sequence Information

Coding Sequence
ATGAAATATAAAATTGCAGACATCGGCCGCGCCGCTAGTAAACACTCTTTGAAAATTAACACCTTGCCCTCTAAGAAAAGTAACAGCCCGGGTGCGCAGGGTGCTCGAGTCGATGAAAAGGGTCCGTTGAAATTCGTGCAGAGAATATTTAGCAAATCCAAAGGGAGCGATCCCGTGGCGTTAAAGGAAATATCTAAGAGTAGTGGGCGACAGTCCCCGGTGGCGCGCCCGGATAACATGAATCACACGCCTGCACCTGACAGGCAGCAGCACGACCCTAATGTAAACCAAGTCGAGGAGATGGAAACGCAGGAAGtgGAAACTGTGGACACAGCTACAGACAAGATTTGGATTGAAGATCTGATGAAGGGGCCAAATGGTGGTGTAGTTATGAATGATGTAATGAAGAACCAGGAAACCTCCTCATCTGATATGCCATTGGCTTGTCTCGACGCTGAAATGGAGGATGACGATTCGCGTTCAGAGGCGACGTTCCGCTTCACTGTACATAACTTCAGGAACCTCAAGGACTCTGTCCTGTCTCCGCCGTGCTACGTCCGCAACCTGCCATGGAAGATTATGGTGATGCCGCGGCAAGGGCCGTCGCCGGACCGCCAGCAGCAGAAGTCTCTGGGCTTCTTCCTCCAGTGCAACGGAGAGAGTGAGTCGTCGAGCTGGACTTGCTATGCTATGGCCGAGCTCAGACTCATCTCTCACAAGCCAGACACCGAACCATTTTATAGAAAGATTCACCATTTGTTTCACAGTAAGGAAAACGATTGGGGTTTCTCTCACTTCATGTCGTGGTCTGACGTGCTGGACAGTGAGAAGGGGTACATTAAAGATGACTCGATCACTCTCGAAGTGCATGTCACCGCGGAGGCTCCGCATGGCGTCTCCTGGGACTCTAAGAAGCACACAGGCTATGTCGGTTTGAAAAACCAAGGCGCAACATGTTACATGAACTCATTGTTACAAACATTGTACTTTACAAATCAATTGAGAAAGGCAGTTTACAAAATGCCCACAGAGTCGGATGACTCAACCAGgtCCGTCGCCTTAGCATTGCAACGAGTGTTCTACGAATTGCAGTTCTCAGACAAACCCGTGGGCACTAAGAAACTTACTAAGAGCTTTGGATGGGAGACACTTGATTCCTTCATGCAGCATGACGTGCAGGAATTTTTAAGGGTGCTCCTGGATAAGTTGGAAAGTAAGATGAAAGGGACCTGTGTGGAAGGGACGGTGCCCAGGTTATTTGAAGGCAAGATGACTTCATACATCAAGTGCAAAAATGTCAATGTCTCCAGCACCAGGGTCGAAACCTTCTATGATATACAGCTTAATATAAAGGGAAAGAAAAACATTGACGAGTCATTCAAGGACTACATAAGCACGGAGACCCTGGATGGCGAGAACAAATACGACGCGGGCGAGCACGGGCTGCAAGAGGCCGAGAAGGGCGTCATATTCGCATCCTTCCCGCCCGTGCTGCACCTGCACCTCATGCGCTTCCAGTACGACCCTATCACGGACAGCTCCGTCAAGTTTAACGATAGATTCGAGTTCTACGAGCACATAAACCTGGACGAGTACCTGCAGGAGAGGCCGGAGACGCCGGCCGACTACACGCTGCACGCCGTGCTCGTGCACTCGGGGGACAACCACGGCGGACACTACGTCGTGTTTATCAACCCCAAGGGCGACGGCAAGTGGTGCAAGTTCGACGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCGATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAATCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAATTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCGATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCCATCGAGTACAATTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGTGCGTTAGTTCATATCAGCTCGACGACGTGGTGTCGCGCTGCACGAAGCAGGAGGCGATCGAGTACAACTACGGCGGCCACGACGAGGACATGGCGCTCACCGTGCGCCACTGCACCAACGCGTACATGCTTGTTTATATCAGGGACTCCCAGTTAAAAACTGTGTTGCAAGAAGTGACTCAAGCAGACATACCGACGGAGCTCAGTGAGAGACTGGCTGAAGAGAAAAGGATCGAGACTATACGCCGCAAGGAGCGCAACGAGGCGCATCTCTACATGAACGTGAACGTGGTCCTCGAGGAAGCGTTCGACGGGCACCAGGGCAACGACCTCTACGACCCGGAGCGCGCGCACTACCGCGTGTTCCGCGTGCGCAAGCAGGCCACCGTCGCCGAGCTCATGGAGATGCTCGCCGAGAACTTCCGCTACCCGCAGAAGCAGCTGCGCCCCTGGCCGTTCAGTGCGCGCTCTAACCAGAGCTCAGACAACGACCTGTACCGCCCGGAGCGCGCGCACTACCGCGTGTTCCGCGTGCGCAAGCAGGCCACCGTCGCCGAGCTCATGGAGATGCTCGCCGAGAACTTCCGCTACCCGCAGAAGCAGCTGCGCCCCTGGCCGTTCAGTGCGCGCTCTAACCAGAGCTCAGACAACGACCTGTACCGCCCGGAGCGCGCGCACTACCGCGTGTTCCGCGTGCGCAAGCAGGCCACCGTCGCCGAGCTCATGGAGATGCTCGCCGAGAACTTCCGCTACCCGCAGAAGCAGCTGCGCCCCTGGCCGTTCAGTGCGCGCTCTAACCAGAGCTCAGACAACGACCTGTACCGCCCGGAGCGCGCGCACTACCGCGTGTTCCGCGTGCGCAAGCAGGCCACCGTCACCGAGCTCATGGAGATGCTCGCCGAGAACTTCCGCTACCCGCAGAAACAGCTGCGCCCCTGGCCTTTCAGTGCGCGCTCTAACCAGAGCTCAGACAACGACCTCTACCGCCCGGAGCGCGCGCACTACCGCGTGTTCCGCGTGCGCAAGCAGGCCACCGTCGCCGAGCTCATGGAGATGCTCGCCGAGAACTTCCGCTACCCGCAGAAGCAGCTGCGCCCCTGGCCGTTCAGTGCGCTCTCTAACCAGAGCTCAGACAACGACCTGTACCGCCCGGAGCGCGCGCACTACCGCGTGTTCCGCGTGCGCAAGCAGGCCACCGTCGCCGAGCTCATGGAGATGCTCGCCGAGAACTTCCGCTACCCGCAGAAGCAGCTGCGCCCCTGGCCGTTCAGTGCGCGCTCTAACCAGTAG
Protein Sequence
MKYKIADIGRAASKHSLKINTLPSKKSNSPGAQGARVDEKGPLKFVQRIFSKSKGSDPVALKEISKSSGRQSPVARPDNMNHTPAPDRQQHDPNVNQVEEMETQEVETVDTATDKIWIEDLMKGPNGGVVMNDVMKNQETSSSDMPLACLDAEMEDDDSRSEATFRFTVHNFRNLKDSVLSPPCYVRNLPWKIMVMPRQGPSPDRQQQKSLGFFLQCNGESESSSWTCYAMAELRLISHKPDTEPFYRKIHHLFHSKENDWGFSHFMSWSDVLDSEKGYIKDDSITLEVHVTAEAPHGVSWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNQLRKAVYKMPTESDDSTRSVALALQRVFYELQFSDKPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTCVEGTVPRLFEGKMTSYIKCKNVNVSSTRVETFYDIQLNIKGKKNIDESFKDYISTETLDGENKYDAGEHGLQEAEKGVIFASFPPVLHLHLMRFQYDPITDSSVKFNDRFEFYEHINLDEYLQERPETPADYTLHAVLVHSGDNHGGHYVVFINPKGDGKWCKFDDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTNQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRCVSSYQLDDVVSRCTKQEAIEYNYGGHDEDMALTVRHCTNAYMLVYIRDSQLKTVLQEVTQADIPTELSERLAEEKRIETIRRKERNEAHLYMNVNVVLEEAFDGHQGNDLYDPERAHYRVFRVRKQATVAELMEMLAENFRYPQKQLRPWPFSARSNQSSDNDLYRPERAHYRVFRVRKQATVAELMEMLAENFRYPQKQLRPWPFSARSNQSSDNDLYRPERAHYRVFRVRKQATVAELMEMLAENFRYPQKQLRPWPFSARSNQSSDNDLYRPERAHYRVFRVRKQATVTELMEMLAENFRYPQKQLRPWPFSARSNQSSDNDLYRPERAHYRVFRVRKQATVAELMEMLAENFRYPQKQLRPWPFSALSNQSSDNDLYRPERAHYRVFRVRKQATVAELMEMLAENFRYPQKQLRPWPFSARSNQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-