Carc022895.2
Basic Information
- Insect
- Coenonympha arcania
- Gene Symbol
- CtBP
- Assembly
- GCA_036785405.1
- Location
- CM072077.1:6904849-6910757[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 11 0.61 1e+03 0.5 0.0 22 52 72 102 66 105 0.87 2 11 0.61 1e+03 0.5 0.0 22 52 150 180 144 183 0.87 3 11 0.61 1e+03 0.5 0.0 22 52 228 258 222 261 0.87 4 11 0.61 1e+03 0.5 0.0 22 52 306 336 300 339 0.87 5 11 0.61 1e+03 0.5 0.0 22 52 384 414 378 417 0.87 6 11 0.61 1e+03 0.5 0.0 22 52 462 492 456 495 0.87 7 11 0.61 1e+03 0.5 0.0 22 52 540 570 534 573 0.87 8 11 0.61 1e+03 0.5 0.0 22 52 618 648 612 651 0.87 9 11 0.61 1e+03 0.5 0.0 22 52 696 726 690 729 0.87 10 11 0.61 1e+03 0.5 0.0 22 52 774 804 768 807 0.87 11 11 0.61 1e+03 0.5 0.0 22 52 852 882 846 885 0.87
Sequence Information
- Coding Sequence
- atggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaagctgctgcgaacgtgctgtgcacgccgcacgccgcgttctactcggacgcgtcggcgcaggagctgcgcgagatggccgcgtcggagatccggcgcgccatcgtgggccgcatccccgactgcctgcgcaactgcgtcaacaaggactacttcctgcccggcgccgcgcccgtgctggcgccgcccgcgccgcccatccccgcgccgcagccgccgcccagcacctacagcgaaggtacccacagctgtccctccacctag
- Protein Sequence
- MAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEAAANVLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFLPGAAPVLAPPAPPIPAPQPPPSTYSEGTHSCPST
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -