Carc024340.1
Basic Information
- Insect
- Coenonympha arcania
- Gene Symbol
- eve
- Assembly
- GCA_036785405.1
- Location
- CM072079.1:8089576-8101357[+]
Transcription Factor Domain
- TF Family
- Homeobox
- Domain
- Homeobox
- PFAM
- PF00046
- TF Group
- Helix-turn-helix
- Description
- This entry represents the homeodomain (HD), a protein domain of approximately 60 residues that usually binds DNA. It is encoded by the homeobox sequence [7, 6, 8], which was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [1, 2], as well as plants [4], fungi [5] and some species of lower eukaryotes. Many members of this group are transcriptional regulators, some of which operate differential genetic programs along the anterior-posterior axis of animal bodies [3]. This domain folds into a globular structure with three α-helices connected by two short loops that harbour a hydrophobic core. The second and third form a helix-turn-helix (HTH) motif, which make intimate contacts with the DNA: while the first helix of this motif helps to stabilise the structure, the second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions, which occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. One particularity of the HTH motif in some of these proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the β-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 10 2.7e-14 6.7e-12 45.9 1.4 1 45 28 72 28 73 0.97 2 10 1.4e-05 0.0035 18.0 0.4 11 45 72 106 69 107 0.93 3 10 4.2e-07 0.00011 22.8 0.5 9 45 106 142 105 142 0.96 4 10 3.6e-07 9.2e-05 23.0 0.6 9 45 142 178 140 179 0.96 5 10 2.3e-07 5.8e-05 23.7 0.5 9 45 178 214 175 215 0.96 6 10 9.3e-05 0.024 15.3 0.1 12 45 215 248 214 249 0.95 7 10 3.6e-07 9.1e-05 23.0 0.6 9 45 248 284 246 285 0.96 8 10 3.8e-07 9.6e-05 23.0 0.5 9 45 284 320 282 320 0.96 9 10 2.6e-07 6.5e-05 23.5 0.5 9 45 320 356 318 357 0.96 10 10 0.0021 0.53 11.0 0.4 12 46 357 391 356 391 0.95
Sequence Information
- Coding Sequence
- ATGCCCATGTCAGATTCagAATCCCTCAGCCCACAGTCAGAACAGATAAATACTTCAAATTCAGCGCCGGATCCCAACAtaaggagGTACCGCACCGCGTTCACTCGGGAGCAGCTCGCGCGATTGGAGAAGGAGTTCATGAAAGAGAACTACGTGTCGCGGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCAGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGGAGCAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCGGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGGAGCAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCGGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGGAGCAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCGGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCGGCCGTGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGGAGCAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCGGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGGAGCAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCGGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGGAGCAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCGGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTTGCGGCCGCGGCGCTGCGAGCTGGAGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGGTAGGTGGTGCCATCACTCACGAGCGAGCGTTCACAGGAGCAGCTCGCGCGGCTGCAGAAGGAGCTCATGAAAGAGAACTACGTGTCGCGGCCGCGGCGCTGCGAGCTGGCGGCGCAGCTGCAGCTGCCCGAGTCCACCATCAAGGCATTACGAGCGAGCGTTCACAGGCGcagaaattattatag
- Protein Sequence
- MPMSDSESLSPQSEQINTSNSAPDPNIRRYRTAFTREQLARLEKEFMKENYVSRPRRCELAAQLQLPESTIKLARLQKELMKENYVSQPRRCELAAQLQLPESTIKEQLARLQKELMKENYVSRPRRCELAAQLQLPESTIKEQLARLQKELMKENYVSRPRRCELAAQLQLPESTIKEQLARLQKELMKENYVSRPRRCELAAQLQLPESTIKLARLQKELMKENYVSRPWRCELAAQLQLPESTIKEQLARLQKELMKENYVSRPRRCELAAQLQLPESTIKEQLARLQKELMKENYVSRPRRCELAAQLQLPESTIKEQLARLQKELMKENYVSRPRRCELAAQLQLPESTIKLARLQKELMKENYVLRPRRCELEAQLQLPESTIKVGGAITHERAFTGAARAAAEGAHERELRVAAAALRAGGAAAAARVHHQGITSERSQAQKLL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -