Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.018 1.2e+02 3.1 0.1 21 47 41 67 25 72 0.80

2 6 3.5e-05 0.25 11.7 0.2 23 45 71 93 68 97 0.91

3 6 7.3e-05 0.52 10.7 0.5 20 48 96 123 92 127 0.88

4 6 0.017 1.2e+02 3.1 0.1 21 44 125 148 123 153 0.91

5 6 0.00026 1.8 9.0 0.0 23 46 155 178 151 183 0.90

6 6 0.79 5.6e+03 -2.2 0.0 26 43 210 227 203 229 0.76

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.018	1.2e+02	3.1	0.1	21	47	41	67	25	72	0.80
2	6	3.5e-05	0.25	11.7	0.2	23	45	71	93	68	97	0.91
3	6	7.3e-05	0.52	10.7	0.5	20	48	96	123	92	127	0.88
4	6	0.017	1.2e+02	3.1	0.1	21	44	125	148	123	153	0.91
5	6	0.00026	1.8	9.0	0.0	23	46	155	178	151	183	0.90
6	6	0.79	5.6e+03	-2.2	0.0	26	43	210	227	203	229	0.76

Coding Sequence: ATGTCTGCTGCTAACCAGTTCCAACTACAAGCAGCTCCAGTTTATAGTTGTAGGCGATGCAAAAAGACTTTCTCCACGAAACGCGAACAAAACCTGCACAAGCGCGAAAACCACGAGCACTCCCAATCCTCATACGAGTGCAAATTGTGCTCGAAATTCTTTTGCAACAACGGAAATCTCGAGCGCCATATGAAGGTGCACAACGATATACGGCCCTACACCTGTGAGATCTGCCAGAAGGCGTTCTCCCAGGCGGTGAATCTACAACGGCACTATTCCGTGCATAATGGAGAGCGTCCATATCAGTGCAGCTTTTGCCAGAAAGCCTTCACGCAGCAGAGTAACATGCGTCGACATGAATTGACCCACACTGGCGAAAAACCATTCGGATGCAAGCGTTGCAATCGGTATTTTTCGCAACGCATCAATCTAAAGAAGCATATTATGGGCCATTTGAATACAAGGCCTTATATGTGTGGCATTTGCCAAAAATCATTCATACAGTCGGCCAACTATAAGAAACACTTGAAGGTGCATGTGAAGGAGGGGAAGTTTGTGGATGAGGCAGCTGCCATTGCTGCAATGGGTGATATAAAACCTAGTCCGACAGCCGAACCTGTCGCCTTCGAATGCGCTGTATGTCGTTCTGTATTTGATAATTTTTCAAACTTTGAATCACACGAAAATCGCTGCAATGGCATTGCGAAGGATGTGCAAGTGGAGAGCACAAGGACTGCAATGGGGCCGATCGGACACTACGCCCCCATACAATTCACCGTTACCCATTTGGACGGAAATGAGATAATTGTGCAAACGAGCAGATAA
Protein Sequence: MSAANQFQLQAAPVYSCRRCKKTFSTKREQNLHKRENHEHSQSSYECKLCSKFFCNNGNLERHMKVHNDIRPYTCEICQKAFSQAVNLQRHYSVHNGERPYQCSFCQKAFTQQSNMRRHELTHTGEKPFGCKRCNRYFSQRINLKKHIMGHLNTRPYMCGICQKSFIQSANYKKHLKVHVKEGKFVDEAAAIAAMGDIKPSPTAEPVAFECAVCRSVFDNFSNFESHENRCNGIAKDVQVESTRTAMGPIGHYAPIQFTVTHLDGNEIIVQTSR

Sequence clustering based on sequence similarity using MMseqs2