Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.048 5.9e+02 -0.1 0.2 4 26 25 47 24 53 0.81

2 3 3.9e-09 4.7e-05 23.3 0.3 23 126 69 171 60 185 0.71

3 3 7.8e-09 9.5e-05 22.3 0.2 343 381 270 308 247 321 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.048	5.9e+02	-0.1	0.2	4	26	25	47	24	53	0.81
2	3	3.9e-09	4.7e-05	23.3	0.3	23	126	69	171	60	185	0.71
3	3	7.8e-09	9.5e-05	22.3	0.2	343	381	270	308	247	321	0.81

Coding Sequence: ATGGTGCACGAGTGTTTAGTCTTGCGCAAGTGTTATACACACATTGATACATTTAAAAATGGCCGACTCGTGGACCGGGACCGGCTTCGAGAGCGTGAGCGTCAGGCACGCGCGGCGATGTCGGTCCAGGCTGAGCAGGCAGCGGCTGGTGGTGGTCCAGACACTCGACATGGCCACCACAATCATGGCCACCATCATCATCACGCCAATTCCCACGCATCCTCTGCCTCTTCGCTCTTCCGTGCCCCTGTCAAGGTCAATCCTGATGCACAAGATCGTGCAACCCAACAGATCCAGTCAAAATTGGGCAATTATTCGCGTGTAAAGCATCTATTGGTTGAGCCACAGATGCTCTTTGGTGTTGTTGATGTGCCACCAAGTCCAGCACCATCAGTACCAGGTTTACCATCATCACGTATACAAAGTAGAACAAATACACCAAATTCACCATCAACCCAAGAGTTCAAGAAACCTGGTTGCAATGGTCCAAGAGGTACATCATCAACAAGTCATACAACACAAAGAGGTGGTTTTGTCAAGCCAGCTGATGGTAAACCACCCtatggtggacgtggtggttATCCTGGCCAACCAGTTAAACATGGTGGTAATAGCAATGATCACAGAAGCCACGGTATTATACCAGCAAAGGGACCACCACCACTTGGTACTAGTGGTAATTCAGCCGGAAACAACAGTGGCCCTGCCTCTTCCGGTAACTGTCCTCCTTTGGCTGGTAATACGAGAATTCACGCTGCTGGATCTAGACTTACTAGGGTACCAATTGATAATgGAATGAGACATGACTTAAATGATAGTGCCGACCTCGAGAATATACTCAAGGAAATGACGATGCCGCCTACACCTCTGACGGCAATTGCCCAGACACCGAGAAAAGAAACAGAGTCTAAGTTTACGTTTAATCCTGTTTTAGCTAAGcTGACCGAAGTGCCACCAACAGACTCTTCCAAACTGCCACGTAAGTtacgaaataataattaa
Protein Sequence: MVHECLVLRKCYTHIDTFKNGRLVDRDRLRERERQARAAMSVQAEQAAAGGGPDTRHGHHNHGHHHHHANSHASSASSLFRAPVKVNPDAQDRATQQIQSKLGNYSRVKHLLVEPQMLFGVVDVPPSPAPSVPGLPSSRIQSRTNTPNSPSTQEFKKPGCNGPRGTSSTSHTTQRGGFVKPADGKPPYGGRGGYPGQPVKHGGNSNDHRSHGIIPAKGPPPLGTSGNSAGNNSGPASSGNCPPLAGNTRIHAAGSRLTRVPIDNGMRHDLNDSADLENILKEMTMPPTPLTAIAQTPRKETESKFTFNPVLAKLTEVPPTDSSKLPRKLRNNN

Sequence clustering based on sequence similarity using MMseqs2