Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00018 0.77 9.9 0.1 16 50 41 75 32 79 0.85

2 5 0.00028 1.2 9.2 0.2 23 45 76 98 72 101 0.89

3 5 0.0031 13 5.9 0.3 20 44 101 125 97 133 0.85

4 5 0.044 1.9e+02 2.2 0.1 21 44 130 153 127 158 0.90

5 5 0.00097 4.1 7.5 0.0 23 45 160 182 156 188 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00018	0.77	9.9	0.1	16	50	41	75	32	79	0.85
2	5	0.00028	1.2	9.2	0.2	23	45	76	98	72	101	0.89
3	5	0.0031	13	5.9	0.3	20	44	101	125	97	133	0.85
4	5	0.044	1.9e+02	2.2	0.1	21	44	130	153	127	158	0.90
5	5	0.00097	4.1	7.5	0.0	23	45	160	182	156	188	0.91

Coding Sequence: atgacCTCGAGAGAGGAATTTGAGGAAACGATGCCACTAAATGGTGTGGTAGCCATGTATACATGCAAACGGTGTAACAAGATATTCCCCTGTAAACGTGATCAACTATTACACAAAAAAGAAGTGCACTCCCAAACAAAATCCTCCTACGAATGTAAAatctgttcaaaatatttttgcaacagTGGCAATTTGGAACGTCACATGAAGGTACACAATGATGTACGACCATTTGTTTGTCGTATTTGTGGTAAAGCCTTTGCACAGTCTGTTAATTTAAATCGTCACTATTCCGTACATAACGGCGAACGTCCGTATCCATGTACATTTTGTGCGAAAACCTTTACACAACAATCAAACATGCAACGCCATCAGCTAACACATACGGGAGAGAAACCATTTCGTTGTAAACGTTGTGGACGTTATTTCTCACAGCGTGTTAACCTTAAAAAGCATATTATGGGTCATTTGAATACAAAACCGTACACGTGCAAAATATGTCAAAAATCTTTCATACAATTgggtaattttaaaaaacatttacagTCACATGTCAAGGATGGCATAGAGATCGATATGAAGGCGATAGTGGCCGAGGCACAGGCATTGGCAAAACAAAGTTTAGAAATGGCCGATGATCAACCTGTTGGGTTTGAATGTGCTGTCTGTCGtttgattttcaataatttcaccGACTTCGAAATGCATGAAAGTGAGTGCAATGATAATGCACAAGCTGCCATAGAGCAAAAATTCAATCCTGATGAACAACTACATGAAGTTGTTGTCGAAGAGGTAGAAGATCATGTTGAAGAGCAAATTATAGCTCACGATGGGGTTGTTAATGGTGGACACTTTGGTAGTTACGCACCTTTAAAATTTAGTGTCTCCCAATTAGATACAcatgaaataattattgaaaccagtcgataa
Protein Sequence: MTSREEFEETMPLNGVVAMYTCKRCNKIFPCKRDQLLHKKEVHSQTKSSYECKICSKYFCNSGNLERHMKVHNDVRPFVCRICGKAFAQSVNLNRHYSVHNGERPYPCTFCAKTFTQQSNMQRHQLTHTGEKPFRCKRCGRYFSQRVNLKKHIMGHLNTKPYTCKICQKSFIQLGNFKKHLQSHVKDGIEIDMKAIVAEAQALAKQSLEMADDQPVGFECAVCRLIFNNFTDFEMHESECNDNAQAAIEQKFNPDEQLHEVVVEEVEDHVEEQIIAHDGVVNGGHFGSYAPLKFSVSQLDTHEIIIETSR

Sequence clustering based on sequence similarity using MMseqs2