Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.91 1.3e+03 -1.0 0.0 41 51 115 125 111 132 0.76

2 3 7.5 1.1e+04 -3.9 2.0 58 62 208 212 203 215 0.60

3 3 9.2e-15 1.4e-11 43.8 12.1 1 68 219 283 219 284 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.91	1.3e+03	-1.0	0.0	41	51	115	125	111	132	0.76
2	3	7.5	1.1e+04	-3.9	2.0	58	62	208	212	203	215	0.60
3	3	9.2e-15	1.4e-11	43.8	12.1	1	68	219	283	219	284	0.90

Coding Sequence: ATGTTTCGATTACTTTCAACGGAAAGTAAACAGAaggtaaatattgaattgaatggatgTGAATTGGTTGAGTGTCTTGACGAAGCAGTGCAGAGTGATTCATTTTGTAACAACCATACACTTGTGGAAGTAACTGGAAGTTGTAATTCGATAGTATCTAAGGTTAAGATAAACGACTGTCCAAAATCTGTGgttataaaagaagaaaagccaatTTGTAAATGTCCCAACAAAATTCCTGAATCGAATCAacgtaatttattaaaatcttgTGATTATCAAGCAAATTCTGAAGACTCGATTTGTTCGACAAGACAAAAACTAAGCGAAGGACAAAGCCACGTTTGTCTTTATTTACCCTGTGCCATGGATTCCGATTCATATGATGATGTGACACCAAAGACGGTGAAAATCAAATGTACCCGTGATATTGATTTAACTGAATCATATTCACCATGTTCAACGCCACGTGGTACGAGGAAAAATTCACCAATACCAAGTCCACGTTCAACAACATGTTCATCACAGCAACcatcaaattcatcatcaaaaGTTGATTGTAGTCGTGAAAATAGGAAACCATGTGGTGGGAAGAAGCAAGTTAAACCGTGTGTACCAAAAAAGTGTAAAAATTGTCCAAATGATAATTTAGGGCCAGAACCTGTTGAACTATTATGCCCATGTTGTAATCGTGATataacaacaataattaaatgtaaattgaaacTAAAGTATCATTTTCATGCGTTACTATTAACGCCACTACTAATGTGCTGTATCCCATACATGATGAAGGATGCCCGTCAGATAATCCATTATTGTTGCCATTGTCATACAAAATTGGGCTATGGTATACCAGTGGTTGTTGAGAAACCGCGATGTGATAGTAAACAGACTGAACCTGTCTTTTTCACCGGAGCATAG
Protein Sequence: MFRLLSTESKQKVNIELNGCELVECLDEAVQSDSFCNNHTLVEVTGSCNSIVSKVKINDCPKSVVIKEEKPICKCPNKIPESNQRNLLKSCDYQANSEDSICSTRQKLSEGQSHVCLYLPCAMDSDSYDDVTPKTVKIKCTRDIDLTESYSPCSTPRGTRKNSPIPSPRSTTCSSQQPSNSSSKVDCSRENRKPCGGKKQVKPCVPKKCKNCPNDNLGPEPVELLCPCCNRDITTIIKCKLKLKYHFHALLLTPLLMCCIPYMMKDARQIIHYCCHCHTKLGYGIPVVVEKPRCDSKQTEPVFFTGA

Sequence clustering based on sequence similarity using MMseqs2