Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.022 65 3.2 0.2 26 49 126 149 98 154 0.87

2 6 0.00046 1.3 8.6 0.1 21 44 176 199 169 207 0.84

3 6 0.0013 3.9 7.1 0.0 23 47 206 230 203 235 0.83

4 6 0.0036 11 5.7 0.0 21 50 232 261 229 266 0.89

5 6 0.012 36 4.0 0.1 23 48 265 289 262 292 0.88

6 6 1.4e-05 0.041 13.4 0.0 23 45 293 315 288 321 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.022	65	3.2	0.2	26	49	126	149	98	154	0.87
2	6	0.00046	1.3	8.6	0.1	21	44	176	199	169	207	0.84
3	6	0.0013	3.9	7.1	0.0	23	47	206	230	203	235	0.83
4	6	0.0036	11	5.7	0.0	21	50	232	261	229	266	0.89
5	6	0.012	36	4.0	0.1	23	48	265	289	262	292	0.88
6	6	1.4e-05	0.041	13.4	0.0	23	45	293	315	288	321	0.90

Coding Sequence: ATGTATTCCTCGTCACTGtttaatttctcgccaataaatcatttgaatgaaagtaTGTTTCATTTACAACCAACGCCGTCACAACAAATCCACCAACATCAGGAGATAATCATAAAGCAAGAGCCGTTGCATTTAAGTGGTTTGCATAATCACAATGGTCATAATGGGTATCAAAACCAGAATCACTCATTGTCCCATGTTGTTACAAAAATAGAACCTGGTACTCTAATGCACGATAGCCATCATCTGTTACAGCCTTTATTACCGTCCACCTATTCGGCCactcattatcatcatcatcatccctCAACGAACAATCCACCAACAACAATGccgaatcaaattgatataaaaccaGTAGTAAAccccaaaaataaatgttctCAATGCAAAAAGGTGTTCAATACACGTCAGGAGTTAACAGAGCACAAGCAACTCCGACACGTAGGTTCACATCCGTGTACGACTTGTGATAAAACGTTTGCGTCTCAAAGCAGCCTATGGAAACACCAGAAAAGTCATCTGGGGGAACGTCCATTCATTTGCACCATTTGCCAGAAAGGATTTACACAGCTTGCAAATCTTCAACGGCACAGCCTCATTCATACTGGCATAAAGCCTTTTAAGTGTCCAATATGTGATAAAGCATTTACTCAACAAGCGAATGTTGTTAAACATCAATTGCTTCACACAGgtgaaaaaccattttcatGTGGAAACTGTGGCAAGGCGTTCTCACAGCGAGCGAATCTAAAGAAACATGAGATGATCCATACATTTGCACTGGGACAGAAACCATTCCAGTGTACAACATGTAATAAGGCGTTCTCACAACGTGCCAACTTGAAGAAACATGAACTCACCCACAGTGGTGTTCGACCACACACCTGTCCAGTGTGCTTTAAAACTTATGCCCAGTTTGCGAATATGAAGAAACATATGAAAACCCATGAGAAAGAGAAATCAAAGGAAACAAGAGACATAAATGAAACTGTTGAAGAGATCATCGGCGAATAG
Protein Sequence: MYSSSLFNFSPINHLNESMFHLQPTPSQQIHQHQEIIIKQEPLHLSGLHNHNGHNGYQNQNHSLSHVVTKIEPGTLMHDSHHLLQPLLPSTYSATHYHHHHPSTNNPPTTMPNQIDIKPVVNPKNKCSQCKKVFNTRQELTEHKQLRHVGSHPCTTCDKTFASQSSLWKHQKSHLGERPFICTICQKGFTQLANLQRHSLIHTGIKPFKCPICDKAFTQQANVVKHQLLHTGEKPFSCGNCGKAFSQRANLKKHEMIHTFALGQKPFQCTTCNKAFSQRANLKKHELTHSGVRPHTCPVCFKTYAQFANMKKHMKTHEKEKSKETRDINETVEEIIGE

Sequence clustering based on sequence similarity using MMseqs2